Research on Chemical Intermediates

, Volume 39, Issue 4, pp 1745–1751 | Cite as

Synthesis of 12-aryl-8,9,10,12-tetrahydrobenzo[a]xanthene-11-ones catalyzed by biodegradable ionic liquid

  • Dong Fang
  • Jin-ming Yang
  • Yan-fang Cao


A biodegradable acyclic SO3H-functionalized ionic liquid has been used as a novel catalyst for the synthesis of 12-aryl-8,9,10,12-tetrahydrobenzo[a]xanthene-11-ones via one-pot multi-component condensation of β-naphthol, aromatic aldehydes, and cyclic 1,3-dicarbonyl compounds, under solvent-free conditions, to afford good to excellent yields ranging from 85 to 93 % within 30–60 min. After the reaction the products could be simply separated from the reaction mixture and the catalyst could be recycled and reused several times without noticeable reduction of catalytic activity.

Graphical Abstract


Xanthene Synthesis Biodegradable ionic liquid Solvent-free Multi-component reaction 



We express our sincere thanks to the Ministry of Science and Technology of the P.R. China (11C26213201395), Jiangsu Provincial Department of Education (JHB2011-52), and the Key Laboratory of Organic Synthesis of Jiangsu Province (KJS1112) for financial assistance.


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Copyright information

© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  1. 1.Department of Pharmaceutical EngineeringYancheng Normal UniversityJiangsuPeople’s Republic of China

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