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Research on Chemical Intermediates

, Volume 38, Issue 9, pp 2271–2275 | Cite as

Catalyst-free synthesis of dihydropyridine from barbituric acid in water

  • Najmadin Azizi
  • Akbar Mobinikhaledi
  • Alireza Khajeh Amiri
  • Hossein Ghafuri
Article

Abstract

An operationally simple, atom-economical, and green procedure has been developed for the synthesis of dihydropyridine derivatives by a simple condensation of barbituric acid, aldehyde, and ammonium acetate in water under catalyst-free conditions. Excellent yields and purity were obtained with only filtration and washing with hot water and ethanol.

Keywords

Aldehydes Barbituric acid Dihydropyridine Novel hydrogen bonding Water chemistry 

Notes

Acknowledgments

The financial support of this work provided by Chemistry and Chemical Research Center of Iran and Iran National Science Foundation (INSF) is gratefully appreciated.

Supplementary material

11164_2012_543_MOESM1_ESM.doc (10.9 mb)
Supplementary material 1 (DOC 11157 kb)

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Copyright information

© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  1. 1.Chemistry and Chemical Engineering Research Center of IranTehranIran
  2. 2.Department of Chemistry, Faculty of SciencesArak UniversityArakIran
  3. 3.Department of ChemistryPayame Noor UniversityTehranIran

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