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Catalyst-free synthesis of dihydropyridine from barbituric acid in water

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Abstract

An operationally simple, atom-economical, and green procedure has been developed for the synthesis of dihydropyridine derivatives by a simple condensation of barbituric acid, aldehyde, and ammonium acetate in water under catalyst-free conditions. Excellent yields and purity were obtained with only filtration and washing with hot water and ethanol.

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Acknowledgments

The financial support of this work provided by Chemistry and Chemical Research Center of Iran and Iran National Science Foundation (INSF) is gratefully appreciated.

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Authors and Affiliations

  1. Chemistry and Chemical Engineering Research Center of Iran, P.O. Box 14335-186, Tehran, Iran

    Najmadin Azizi

  2. Department of Chemistry, Faculty of Sciences, Arak University, Arak, 38156-879, Iran

    Akbar Mobinikhaledi & Alireza Khajeh Amiri

  3. Department of Chemistry, Payame Noor University, Damavand Branch, Tehran, Iran

    Hossein Ghafuri

Authors
  1. Najmadin Azizi
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  2. Akbar Mobinikhaledi
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  3. Alireza Khajeh Amiri
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  4. Hossein Ghafuri
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Corresponding authors

Correspondence to Najmadin Azizi or Alireza Khajeh Amiri.

Electronic supplementary material

Experimental details and spectroscopic characterization (copy of 1H and 13C NMR and mass) of all compounds.

Supplementary material 1 (DOC 11157 kb)

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Azizi, N., Mobinikhaledi, A., Amiri, A.K. et al. Catalyst-free synthesis of dihydropyridine from barbituric acid in water. Res Chem Intermed 38, 2271–2275 (2012). https://doi.org/10.1007/s11164-012-0543-8

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  • DOI: https://doi.org/10.1007/s11164-012-0543-8

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