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Research on Chemical Intermediates

, Volume 38, Issue 2, pp 615–627 | Cite as

An efficient 2-(1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate (TBTU)-mediated synthesis of 5-(trifluoromethyl)-N-alkyl-1-(3-phenylisoquinoline-1-yl)-1H-pyrazole-4-carboxamides

  • K. Prabakaran
  • F. Nawaz Khan
  • Jong Sung Jin
Article

Abstract

A series of 5-(trifluoromethyl)-N-alkyl-1-(3-phenylisoquinoline-1-yl)-1H-pyrazole-4-carboxamides 4 has been effectively achieved in high yield and purity from the reaction of pyrazole carboxylic acid 2 with amines 3 in the presence of TBTU as a catalyst and diisopropyl ethylamine as a base in acetonitrile at room temperature.

Keywords

Isocoumarins TBTU Pyrazole-4-carboxamide 1,3-Disubstituted isoquinoline 

Notes

Acknowledgment

The authors wish to express their gratitude to the Management, VIT University, India for their support and facilities.

Supplementary material

11164_2011_375_MOESM1_ESM.docx (12 mb)
Supplementary material 1 (DOCX 12300 kb)

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Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  • K. Prabakaran
    • 1
  • F. Nawaz Khan
    • 1
    • 2
  • Jong Sung Jin
    • 2
  1. 1.Organic and Medicinal Chemistry Research Laboratory, Organic Chemistry Division, School of Advanced SciencesVIT UniversityVelloreIndia
  2. 2.Division of High Technology Materials Research, Busan CenterKorea Basic Science Institute (KBSI)BusanKorea

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