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Synthetic, structural, and antimicrobial studies of organotin(IV) complexes of semicarbazone, thiosemicarbazone derived from 4-hydroxy-3-methoxybenzaldehyde

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Abstract

Reaction of dibutyltin dichloride, dimethyltin dichloride, and tributyltin chloride with ligands derived from thiosemicarbazone and semicarbazone leads to the formation of a new series of organotin(IV) complexes of general formula R2SnCl2·L and R3SnCl·L (where L ligands derived from the condensation of thiosemicarbazide and semicarbazide with 4-hydroxy-3-methoxybenzaldehyde). The authenticity of these ligands and their metal complexes have been established on the basis of elemental analysis, conductance measurements, molecular weight determinations, infrared, 1H NMR, 13C NMR, 119Sn NMR, and UV spectral studies. These studies showed that the ligands coordinate to the metal atom in a bidentate. An octahedral structure is proposed for the organotin(IV) complexes. The ligands and its metal complexes are screened for their antimicrobial activities against some Gram-positive and Gram-negative bacteria, and fungus. The studies demonstrated that metalation can increase the antimicrobial activity rather than the free ligands.

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Acknowledgments

The author is thankful to the dean of the Faculty of Engineering and Technology, Mody Institute of Technology and Science, Deemed University, Lakshmangarh, Sikar for providing the necessary facilities. The authors are also grateful to Dr. Ankit Gandhi for linguistic corrections.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Engineering & Technology, Mody Institute of Technology and Science, Lakshmangarh, Sikar, India

    H. L. Singh & J. B. Singh

  2. Department of Biotechnology, Faculty of Art, Science and Commerce, Mody Institute of Technology and Science, Lakshmangarh, Sikar, India

    K. P. Sharma

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  1. H. L. Singh
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Correspondence to H. L. Singh.

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Singh, H.L., Singh, J.B. & Sharma, K.P. Synthetic, structural, and antimicrobial studies of organotin(IV) complexes of semicarbazone, thiosemicarbazone derived from 4-hydroxy-3-methoxybenzaldehyde. Res Chem Intermed 38, 53–65 (2012). https://doi.org/10.1007/s11164-011-0325-8

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