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Research on Chemical Intermediates

, Volume 38, Issue 1, pp 53–65 | Cite as

Synthetic, structural, and antimicrobial studies of organotin(IV) complexes of semicarbazone, thiosemicarbazone derived from 4-hydroxy-3-methoxybenzaldehyde

  • H. L. Singh
  • J. B. Singh
  • K. P. Sharma
Article

Abstract

Reaction of dibutyltin dichloride, dimethyltin dichloride, and tributyltin chloride with ligands derived from thiosemicarbazone and semicarbazone leads to the formation of a new series of organotin(IV) complexes of general formula R2SnCl2·L and R3SnCl·L (where L ligands derived from the condensation of thiosemicarbazide and semicarbazide with 4-hydroxy-3-methoxybenzaldehyde). The authenticity of these ligands and their metal complexes have been established on the basis of elemental analysis, conductance measurements, molecular weight determinations, infrared, 1H NMR, 13C NMR, 119Sn NMR, and UV spectral studies. These studies showed that the ligands coordinate to the metal atom in a bidentate. An octahedral structure is proposed for the organotin(IV) complexes. The ligands and its metal complexes are screened for their antimicrobial activities against some Gram-positive and Gram-negative bacteria, and fungus. The studies demonstrated that metalation can increase the antimicrobial activity rather than the free ligands.

Keywords

Organotin(IV) complexes Antimicrobial activity Thiosemicarbazone Semicarbazone Spectral studies 

Notes

Acknowledgments

The author is thankful to the dean of the Faculty of Engineering and Technology, Mody Institute of Technology and Science, Deemed University, Lakshmangarh, Sikar for providing the necessary facilities. The authors are also grateful to Dr. Ankit Gandhi for linguistic corrections.

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Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  1. 1.Department of ChemistryFaculty of Engineering & Technology, Mody Institute of Technology and ScienceLakshmangarhIndia
  2. 2.Department of BiotechnologyFaculty of Art, Science and Commerce, Mody Institute of Technology and ScienceLakshmangarhIndia

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