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Research on Chemical Intermediates

, Volume 37, Issue 8, pp 1029–1039 | Cite as

Facile synthesis and biological evaluation of novel fluorine-containing N-nitro-N′-substituted phenylurea

  • Yunchun Wang
  • Zhongyuan Bai
  • Zengjun Wei
  • Shengzhen Xu
  • Xuegang Li
  • Jianhong Li
  • Xiufang Cao
  • Changshui Chen
Article

Abstract

Twenty-two novel N-nitro-N′-substituted phenyl-N-(2,6-dibromo-4-fluorophenyl)urea derivatives were designed and synthesized via a simple and convenient BTC ‘one-pot’ procedure using DMAP as the catalyst. The structures of all newly synthesized compounds were confirmed by IR, 1H NMR, and elemental analysis, and a part has been identified by 13C NMR. The preliminary bioassay indicates that the target compounds possesses moderate herbicidal activity against Sorghum sudanense. However, some of the title compounds presented high plant growth regulating activity against rape.

Keywords

N-nitrourea Synthesis Biological activity 

Notes

Acknowledgments

We gratefully acknowledge the support of this work by “the Fundamental Research Funds for the Central Universities” (2009BQ027, 2010JC001, 2008XKJC005).

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Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  • Yunchun Wang
    • 1
  • Zhongyuan Bai
    • 1
  • Zengjun Wei
    • 1
  • Shengzhen Xu
    • 1
  • Xuegang Li
    • 1
  • Jianhong Li
    • 2
  • Xiufang Cao
    • 1
  • Changshui Chen
    • 1
  1. 1.College of ScienceHuazhong Agricultural UniversityWuhanChina
  2. 2.Department of Plant ProtectionHuazhong Agricultural UniversityWuhanChina

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