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Research on Chemical Intermediates

, Volume 37, Issue 8, pp 811–820 | Cite as

One-pot synthesis of β-acetamido-β-arylpropiophenone employing trifluoroacetic acid as an efficient catalyst

  • Xing-Hua Zhang
  • Li Fan
  • Jian Liu
  • Da-Cheng Yang
Article

Abstract

Trifluoroacetic acid as an efficient catalyst promoting the Dakin–West reaction at ambient temperature is reported for the first time in this paper. A few efficacious auxiliary catalysts were also developed for the Dakin–West reaction. A variety of substituted aryl aldehydes and aryl ketones were found to be applicable to the preparation of some new β-acetamido-β-arylpropiophenones. This procedure has several advantages such as high yields, short reaction time, and smaller amount (0.30 mol%) of catalyst.

Keywords

Trifluoroacetic acid β-Acetamido ketones One-pot 3-Nitroacetophenone 

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Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  • Xing-Hua Zhang
    • 1
  • Li Fan
    • 1
  • Jian Liu
    • 1
  • Da-Cheng Yang
    • 1
  1. 1.School of Chemistry and Chemical EngineeringSouthwest UniversityChongqingChina

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