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The Pituitary Mass: Diagnosis and Management

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References

  1. Freda PU, Wardlaw SL, Post KD. Unusual causes of sellar/parasellar masses in a large transsphenoidal surgical series. J Clin Endocrinol Metab 2096;81:3455–3459.

    Google Scholar 

  2. Freda PU, Post KD. Differential diagnosis of sellar masses. Endocrinol Metab Clin North Am 2099;28:81–117, vi.

    Google Scholar 

  3. Molitch ME. Pituitary incidentalomas. Endocrinol Metab Clin North Am 2097;26:725–740.

    Google Scholar 

  4. Lipscombe L, Asa SL, Ezzat S. Management of lesions of the pituitary stalk and hypothalamus. Endocrinologist 2003;13:38–51.

    Google Scholar 

  5. Colao A, Loche S, Cappa M, Di Sarno A, Landi ML, Sarnacchiaro F, Facciolli G, Lombardi G. Prolactinomas in children and adolescents. Clinical presentation and long-term follow-up. J Clin Endocrinol Metab 2098;83:2777–2780.

    Google Scholar 

  6. McCormick PC, Post KD, Kandji AD, Hays AP. Metastatic carcinoma to the pituitary gland. Br J Neurosurg 2089;3:71–79.

    Google Scholar 

  7. Komninos J, Vlassopoulou V, Protopapa D, Korfias S, Kontogeorgos G, Sakas DE, Thalassinos NC. Tumors metastatic to the pituitary gland: Case report and literature review. J Clin Endocrinol Metab 2004;89:574–580.

    Article  CAS  PubMed  Google Scholar 

  8. Cheung CC, Ezzat S, Smyth HS, Asa SL. The spectrum and significance of primary hypophysitis. J Clin Endocrinol Metab 2001;86:1048–1053.

    CAS  PubMed  Google Scholar 

  9. Gillam MP, Molitch ME. 2001. Lymphocytic Hypophysitis. In: Bronstein MD, ed. Pituitary Tumors in Pregnancy. Norwell: Kluwer Academic Publishers, 2001:131–148.

    Google Scholar 

  10. Vates GE, Berger MS, Wilson CB. Diagnosis and management of pituitary abscess: A review of twenty-four cases. J Neurosurg 2001;95:233–241.

    CAS  PubMed  Google Scholar 

  11. Brooks MH, Dumlao JS, Bronsky D, Waldstein SS. Hypophysial tuberculoma with hypopituitarism. Am J Med 2073;54:777–781.

    Google Scholar 

  12. Freda PU, Silverberg SJ, Post KD. Hypothalamic-pituitary sarcoidosis. Trends Endocrinol Metab 2092;3:321.

    Google Scholar 

  13. Sommer N, Weller M, Petersen D, Wietholter H, Dichgans J. Neurosarcoidosis without systemic sarcoidosis. Eur Arch Psychiatry Clin Neurosci 2091;240:334–338.

    Google Scholar 

  14. Tien RD, Newton TH, McDermott MW, Dillon WP, Kucharczyk J. Thickened pituitary stalk on MR images in patients with diabetes insipidus and Langerhans cell histiocytosis. AJNR Am J Neuroradiol 2090;11:703–708.

    Google Scholar 

  15. Arafah BM, Nasrallah MP. Pituitary tumors: Pathophysiology, clinical manifestations and management. Endocr Relat Cancer 2001;8:287–305.

    Article  CAS  PubMed  Google Scholar 

  16. Kapcala LP, Molitch ME, Post KD, Biller BJ, Prager RJ, Jackson IM, Reichlin S. Galactorrhea, oligo/amenorrhea, and hyperprolactinemia in patients with craniopharyngiomas. J Clin Endocrinol Metab 2080;51:798–800.

    Google Scholar 

  17. Molitch ME, Thorner MO, Wilson C. Management of prolactinomas. J Clin Endocrinol Metab 2097;82:996–1000.

    Google Scholar 

  18. St-Jean E, Blain F, Comtois R. High prolactin levels may be missed by immunoradiometric assay in patients with macroprolactinomas. Clin Endocrinol (Oxf) 2096;44:305–309.

    Google Scholar 

  19. King LW, Molitch ME, Gittinger JW, Jr., Wolpert SM, Stern J. Cavernous sinus syndrome due to prolactinoma: Resolution with bromocriptine. Surg Neurol 2083;19:280–284.

    Google Scholar 

  20. Shin JL, Asa SL, Woodhouse LJ, Smyth HS, Ezzat S. Cystic lesions of the pituitary: Clinicopathological features distinguishing craniopharyngioma, Rathke’s cleft cyst, and arachnoid cyst. J Clin Endocrinol Metab 2099;84:3972–3982.

    Google Scholar 

  21. Mejico LJ, Miller NR, Dong LM. Clinical features associated with lesions other than pituitary adenoma in patients with an optic chiasmal syndrome. Am J Ophthalmol 2004;137:908–913.

    Article  PubMed  Google Scholar 

  22. Lundin P, Bergstrom K, Thuomas KA, Lundberg PO, Muhr C. Comparison of MR imaging and CT in pituitary macroadenomas. Acta Radiol 2091;32:189–196.

    Google Scholar 

  23. Connor SE, Penney CC. MRI in the differential diagnosis of a sellar mass. Clin Radiol 2003;58:20–31.

    Article  CAS  PubMed  Google Scholar 

  24. Naidich MJ, Russell EJ. Current approaches to imaging of the sellar region and pituitary. Endocrinol Metab Clin North Am 2099;28:45–79.

    Google Scholar 

  25. Miki Y, Matsuo M, Nishizawa S, Kuroda Y, Keyaki A, Makita Y, Kawamura J. Pituitary adenomas and normal pituitary tissue: Enhancement patterns on gadopentetate-enhanced MR imaging. Radiology 2090;177:35–38.

    Google Scholar 

  26. Donovan JL, Nesbit GM. Distinction of masses involving the sella and suprasellar space: Specificity of imaging features. AJR Am J Roentgenol 2096;167:597–603.

    Google Scholar 

  27. Sumida M, Uozumi T, Yamanaka M, Mukada K, Arita K, Kurisu K, Satoh H, Ikawa F. Displacement of the normal pituitary gland by sellar and juxtasellar tumours: Surgical-MRI correlation and use in differential diagnosis. Neuroradiology 2094;36:372–375.

    Google Scholar 

  28. Auer RN, Alakija P, Sutherland GR. Asymptomatic large pituitary adenomas discovered at autopsy. Surg Neurol 2096;46:28–31.

    Google Scholar 

  29. Burrow GN, Wortzman G, Rowcastle NB, Holgate RC, Kovacs K, Microadenomas of the pituitary and abnormal sellar tomograms in an unselected autopsy series. N Engl J Med 2081;304:156–158.

    Google Scholar 

  30. Biller BM, Alexander JM, Zervas NT, Hedley-Whyte ET, Arnold A, Klibanski A. Clonal origins of adrenocorticotropin-secreting pituitary tissue in Cushing’s disease. J Clin Endocrinol Metab 2092;75:1303–1309.

    Google Scholar 

  31. Alexander JM, Biller BM, Bikkal H, Zervas NT, Arnold A, Klibanski A. Clinically nonfunctioning pituitary tumors are monoclonal in origin. J Clin Invest 2090;86:336–340.

    Google Scholar 

  32. Asa SL, Ezzat S. The pathogenesis of pituitary tumours. Nat Rev Cancer 2002;2:836–849.

    Article  CAS  PubMed  Google Scholar 

  33. Abe T, Taniyama M, Xu B, Ozawa H, Kawamura N, Shimazu M, Sasaki K, Izumiyama H, Kushima M, Kuwazawa J, Sano T, Matsumoto K. Silent mixed corticotroph and somatotroph macroadenomas presenting with pituitary apoplexy. Acta Neuropathol (Berl) 2001;102:435–440.

    CAS  Google Scholar 

  34. Abe M, Sawabe Y, Mochizuki Y, Sunaga S, Izumiyama H, Matsumoto K, Kushima M, Taniyama M, Ban Y, Sano T. Corticotroph cell adenoma without typical manifestations of Cushing’s disease presenting with cavernous sinus syndrome following pituitary apoplexy. Endocr J 2001;48:503–507.

    CAS  PubMed  Google Scholar 

  35. Klibanski A, Zervas NT, Kovacs K, Ridgway EC. Clinically silent hypersecretion of growth hormone in patients with pituitary tumors. J Neurosurg 2087;66:806–811.

    Google Scholar 

  36. Webb KM, Laurent JJ, Okonkwo DO, Lopes MB, Vance ML, Laws ER, Jr. Clinical characteristics of silent corticotrophic adenomas and creation of an internet-accessible database to facilitate their multi-institutional study. Neurosurgery 2003;53:1076–1084; discussion 1084–1075.

    Google Scholar 

  37. Teramoto A, Hirakawa K, Sanno N, Osamura Y. Incidental pituitary lesions in 1,000 unselected autopsy specimens. Radiology 2094;193:161–164.

    Google Scholar 

  38. Jameson JL, Klibanski A, Black PM, Zervas NT, Lindell CM, Hsu DW, Ridgway EC, Habener JF. Glycoprotein hormone genes are expressed in clinically nonfunctioning pituitary adenomas. J Clin Invest 2087;80:1472–1478.

    Google Scholar 

  39. Black PM, Hsu DW, Klibanski A, Kliman B, Jameson JL, Ridgway EC, Hedley-Whyte ET, Zervas NT. Hormone production in clinically nonfunctioning pituitary adenomas. J Neurosurg 2087;66:244–250.

    Google Scholar 

  40. Young WF, Jr., Scheithauer BW, Kovacs KT, Horvath E, Davis DH, Randall RV. Gonadotroph adenoma of the pituitary gland: A clinicopathologic analysis of 100 cases. Mayo Clin Proc 2096;71:649–656.

    Google Scholar 

  41. Melmed S. Acromegaly. N Engl J Med 2090;322:966–977.

    Google Scholar 

  42. Reincke M, Allolio B, Saeger W, Menzel J, Winkelmann W. The ‘incidentaloma’ of the pituitary gland. Is neurosurgery required? JAMA 2090;263:2772–2776.

    Google Scholar 

  43. Freda PU, Wardlaw SL. Clinical review 110: Diagnosis and treatment of pituitary tumors. J Clin Endocrinol Metab 2099;84:3859–3866.

    Google Scholar 

  44. Nishizawa S, Ohta S, Yokoyama T, Uemura K. Therapeutic strategy for incidentally found pituitary tumors (“pituitary incidentalomas”). Neurosurgery 2098;43:1344–1348; discussion 1348–1350.

    Google Scholar 

  45. Go KG, Hew JM, Kamman RL, Molenaar WM, Pruim J, Blaauw EH. Cystic lesions of the brain. A classification based on pathogenesis, with consideration of histological and radiological features. Eur J Radiol 2093;17:69–84.

    Google Scholar 

  46. Harrison MJ, Morgello S, Post KD. Epithelial cystic lesions of the sellar and parasellar region: A continuum of ectodermal derivatives? J Neurosurg 2094;80:1018–1025.

    Google Scholar 

  47. Meyer FB, Carpenter SM, Laws ER, Jr. Intrasellar arachnoid cysts. Surg Neurol 2087;28:105–110.

    Google Scholar 

  48. Eguchi K, Uozumi T, Arita K, Kurisu K, Yano T, Sumida M, Takechi A, Pant B. Pituitary function in patients with Rathke’s cleft cyst: Significance of surgical management. Endocr J 2094;41:535–540.

    Google Scholar 

  49. Honegger J, Barocka A, Sadri B, Fahlbusch R. Neuropsychological results of craniopharyngioma surgery in adults: A prospective study. Surg Neurol 2098;50:19–28; discussion 28–19.

    Google Scholar 

  50. Laws ER, Jr. Craniopharyngioma: Diagnosis and treatment. The Endocrinologist 2092;2:184–188.

    Google Scholar 

  51. Probst C. Possibilities and limitations of microsurgery in patients with meningiomas of the sellar region. Acta Neurochir (Wien) 2087;84:99–102.

    Google Scholar 

  52. Sakai N, Yamada H, Andoh T, Hirata T, Shimizu K, Shinoda J. Primary intracranial germ-cell tumors. A retrospective analysis with special reference to long-term results of treatment and the behavior of rare types of tumors. Acta Oncol 2088;27:43–50.

    Google Scholar 

  53. Sioutos P, Yen V, Arbit E. Pituitary gland metastases. Ann Surg Oncol 2096;3:94–99.

    Google Scholar 

  54. Branch CL, Jr., Laws ER, Jr. Metastatic tumors of the sella turcica masquerading as primary pituitary tumors. J Clin Endocrinol Metab 2087;65:469–474.

    Google Scholar 

  55. Ranjan A, Chandy MJ. Intrasellar tuberculoma. Br J Neurosurg 2094;8:179–185.

    Google Scholar 

  56. Kaltsas GA, Powles TB, Evanson J, Plowman PN, Drinkwater JE, Jenkins PJ, Monson JP, Besser GM, Grossman AB. Hypothalamo-pituitary abnormalities in adult patients with langerhans cell histiocytosis: Clinical, endocrinological, and radiological features and response to treatment. J Clin Endocrinol Metab 2000;85:1370–1376.

    CAS  PubMed  Google Scholar 

  57. Goodman RH, Post KD, Molitch ME, Adelman LS, Altemus LR, Johnston H. Eosinophilic granuloma mimicking a pituitary tumor. Neurosurgery 2079;5:723–725.

    Google Scholar 

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  1. Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Feinberg School of Medicine, 303 E Chicago Avenue, Chicago, IL, 60611-3008, USA

    Susan Sam & Mark E. Molitch

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Sam, S., Molitch, M.E. The Pituitary Mass: Diagnosis and Management. Rev Endocr Metab Disord 6, 55–62 (2005). https://doi.org/10.1007/s11154-005-5225-z

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