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Psychosocial predictors of quality of life among South Africa adolescents receiving antiretroviral therapy

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Abstract

Purpose

Minimal research has been conducted to understand how fatigue influences quality of life (QOL) among adolescents living with HIV. The purpose of the study was to examine the relationship between fatigue, sleep disturbance, depression, anxiety, pain and QOL among adolescents receiving antiretroviral therapy (ART).

Methods

Using a cross-sectional survey design, we studied 134 South African adolescents receiving an ART at community clinics.

Results

Participants in general reported low levels of fatigue, insomnia, distress and pain and non-problematic levels of QOL. In the regression model, the linear combination of these variables explained 49% of the variance in QOL, a large effect size. Insomnia, anxiety, and depression significantly predicted QOL but surprisingly fatigue and pain did not.

Conclusions

Many members of the sample experienced non-clinical levels of sleep disturbance, fatigue and psychosocial distress. Similarly, QOL was within the normal range. These findings are surprising as the commonly held assumption is that adolescents living with HIV, especially those of poorer socio-economic backgrounds, would experience lower QOL than the norm. Even though scores on the instruments measuring these variables fell in the non-clinical range, they were still robustly predictive of poor QOL. Future research may address the relationship between self-reported adherence and QOL, possibly by examining the role of viral load as a mediating variable. Further research may also focus on non-adherent adolescents to understand the ways in which fatigue and other factors such as school functioning and social interaction influence QOL.

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Acknowledgements

We would like to acknowledge Stellenbosch Universities Sub-Committee A, as well as the University of Bath’s Faculty of Humanities and Social Sciences & Department of Psychology for funding this research. The funding was supported by Universiteit Stellenbosch (ZA) and University of Bath.

Funding

Dr. Loades is funded by the National Institute for Health Research (Doctoral Research Fellowship, DRF-2016-09-021). This report is independent research. The views expressed in this publication are those of the authors(s) and not necessarily those of the NHS, The National Institute for Health Research or the Department of Health. Dr. Kagee is funded by the National Research Foundation.

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Authors and Affiliations

  1. Department of Psychology, Stellenbosch University, Matieland, Private Bag X1, Stellenbosch, South Africa

    A. Kagee, B. Coetzee & S. Du Toit

  2. Department of Psychology, University of Bath, Bath, BA2 7AY, UK

    M. E. Loades

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  1. A. Kagee
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  2. B. Coetzee
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Kagee, A., Coetzee, B., Toit, S.D. et al. Psychosocial predictors of quality of life among South Africa adolescents receiving antiretroviral therapy. Qual Life Res 28, 57–65 (2019). https://doi.org/10.1007/s11136-018-2010-5

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