Quality of Life Research

, Volume 21, Issue 4, pp 563–580 | Cite as

The psychosocial correlates of quality of life in the dialysis population: a systematic review and meta-regression analysis

  • Ramony Chan
  • Robert Brooks
  • Zachary Steel
  • Tracy Heung
  • Jonathan Erlich
  • Josephine Chow
  • Michael Suranyi



The psychosocial correlates of quality-of-life (QoL) research in end-stage renal disease (ESRD) are important in identifying risk and protective factors that may account for the QoL variability. Thus, the present study provides a meta-analysis of these research results.


Published studies reporting associations between any psychosocial factors and QoL were retrieved from Medline, Embase, and PsycINFO. Mean effect sizes were calculated for the associations across psychosocial constructs (affect, stress, cognitive appraisal, social support, personality attributes, and coping process). Multiple hierarchical meta-regressions were applied to moderator analyses.


Eighty-one studies covering a combined sample of 13,240 participants were identified resulting in 377 effect sizes of the association between psychosocial factors and QoL. The overall effect size of the association was medium (0.38). Stress, affect, and cognitive appraisal had the largest effect sizes. Location of study, dialysis type, gender, age and QoL domains measured (general well-being, subjective QoL, and health-related QoL) were significant substantive moderators for the associations.


The present study shows that there is a moderate association between psychosocial variables and QoL in patients with ESRD, consistent across different QoL domains. The psychosocial constructs that have the strongest association with QoL are stress, affect, and cognitive appraisal.


Renal dialysis Kidney failure, chronic Psychological Adaptation Mental Health Quality of life Meta-analysis 



Effect size


End-stage renal disease


Quality of life


Health-related quality of life


Continuous ambulatory peritoneal dialysis


Peritoneal dialysis


Preferred reporting items for systematic reviews and meta-analyses



We are grateful for the authors of the included studies who provided additional data for this meta-analysis and the extensive support from the Renal Unit, Liverpool Hospital in completing this study.

Supplementary material

11136_2011_9973_MOESM1_ESM.docx (67 kb)
Supplementary material 1 (DOCX 68 kb)
11136_2011_9973_MOESM2_ESM.docx (28 kb)
Supplementary material 2 (DOCX 28 kb)


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Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  • Ramony Chan
    • 1
    • 2
    • 3
  • Robert Brooks
    • 2
    • 4
  • Zachary Steel
    • 2
    • 4
  • Tracy Heung
    • 5
  • Jonathan Erlich
    • 2
    • 6
  • Josephine Chow
    • 3
    • 7
  • Michael Suranyi
    • 2
    • 3
  1. 1.Consultation Liaison PsychiatryLiverpool HospitalLiverpool BCAustralia
  2. 2.The University of New South WalesSydneyAustralia
  3. 3.Renal UnitLiverpool HospitalSydneyAustralia
  4. 4.Centre for Population Mental Health Research, Liverpool HospitalSydneyAustralia
  5. 5.The University of Western SydneySydneyAustralia
  6. 6.Department of NephrologyPrince of Wales HospitalSydneyAustralia
  7. 7.The University of SydneySydneyAustralia

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