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Quality of Life Research

, Volume 20, Issue 1, pp 111–118 | Cite as

Long-term quality of life following primary treatment in men with clinical stage T3 prostate cancer

  • Shunichi Namiki
  • Tatsuo Tochigi
  • Shigeto Ishidoya
  • Akihiro Ito
  • Isao Numata
  • Yoichi Arai
Article

Abstract

Objectives

We evaluated the changes of health-related quality of life (HRQOL) during the 5 years after radical prostatectomy (RP) or external beam radiation therapy (EBRT) for clinical stage T3 prostate cancer (cT3PC).

Patients and methods

A total of 750 patients who underwent RP (n = 575) or EBRT (n = 175) participated in our longitudinal outcomes study. Of these patients, 48 RP patients (8%) and 63 EBRT patients (36%) presented with cT3PC and were included in this analysis. Patients completed the general and disease-specific HRQOL with the Short Form 36 (SF-36) and University of California, Los Angeles Prostate Cancer Index, respectively.

Results

When examining the mean SF-36 values by time, there was significant impact on treatment outcomes for several items of the general HRQOL in the RP subjects. Those who underwent EBRT reported no significant changes in the general HRQOL throughout the follow-up period. With regard to disease-specific HRQOL, the RP subjects had significantly worse urinary HRQOL post-operatively than the EBRT subjects (P < 0.001). The scores for sexual function declined over the 60 months, but more so in the RP group. The two groups showed similar bowel HRQOL scores throughout the follow-up periods.

Conclusions

Both primary treatments for cT3PC can offer satisfactory functional outcomes from the HRQOL perspective, except for a persistent decrease in the sexual activity score. These results may guide the treatment selection and clinical management of patients with HRQOL impairments after treatment for cT3PC.

Keywords

T3 prostate cancer Quality of life Radical prostatectomy External beam radiation therapy 

Abbreviations

ADT

Androgen deprivation therapy

ANOVA

Analyses of variance

cT3PC

Clinical stage T3 prostate cancer

EBRT

External beam radiation therapy

HRQOL

Health-related quality of life

IMRT

Intensity-modulated radiation therapy

PSA

Prostate-specific antigen

RP

Radical prostatectomy

SD

Standard deviation

SF-36

RAND 36-Item Short Form

UCLA-PCI

University of California, Los Angeles Prostate Cancer Index

3DCRT

3-dimensional conformal therapy

Notes

Acknowledgments

We thank Emiko Izutsu, Tohoku University Hospital, who assisted in data collection and management.

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Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  • Shunichi Namiki
    • 1
    • 3
  • Tatsuo Tochigi
    • 2
  • Shigeto Ishidoya
    • 1
  • Akihiro Ito
    • 1
  • Isao Numata
    • 3
  • Yoichi Arai
    • 1
  1. 1.Department of UrologyTohoku University Graduate School of MedicineAoba-ku, SendaiJapan
  2. 2.Department of UrologyMiyagi Cancer CenterNatoriJapan
  3. 3.Department of UrologyOsaki Citizen HospitalOsakiJapan

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