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Long-term quality of life following primary treatment in men with clinical stage T3 prostate cancer

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Abstract

Objectives

We evaluated the changes of health-related quality of life (HRQOL) during the 5 years after radical prostatectomy (RP) or external beam radiation therapy (EBRT) for clinical stage T3 prostate cancer (cT3PC).

Patients and methods

A total of 750 patients who underwent RP (n = 575) or EBRT (n = 175) participated in our longitudinal outcomes study. Of these patients, 48 RP patients (8%) and 63 EBRT patients (36%) presented with cT3PC and were included in this analysis. Patients completed the general and disease-specific HRQOL with the Short Form 36 (SF-36) and University of California, Los Angeles Prostate Cancer Index, respectively.

Results

When examining the mean SF-36 values by time, there was significant impact on treatment outcomes for several items of the general HRQOL in the RP subjects. Those who underwent EBRT reported no significant changes in the general HRQOL throughout the follow-up period. With regard to disease-specific HRQOL, the RP subjects had significantly worse urinary HRQOL post-operatively than the EBRT subjects (P < 0.001). The scores for sexual function declined over the 60 months, but more so in the RP group. The two groups showed similar bowel HRQOL scores throughout the follow-up periods.

Conclusions

Both primary treatments for cT3PC can offer satisfactory functional outcomes from the HRQOL perspective, except for a persistent decrease in the sexual activity score. These results may guide the treatment selection and clinical management of patients with HRQOL impairments after treatment for cT3PC.

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Abbreviations

ADT:

Androgen deprivation therapy

ANOVA:

Analyses of variance

cT3PC:

Clinical stage T3 prostate cancer

EBRT:

External beam radiation therapy

HRQOL:

Health-related quality of life

IMRT:

Intensity-modulated radiation therapy

PSA:

Prostate-specific antigen

RP:

Radical prostatectomy

SD:

Standard deviation

SF-36:

RAND 36-Item Short Form

UCLA-PCI:

University of California, Los Angeles Prostate Cancer Index

3DCRT:

3-dimensional conformal therapy

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Acknowledgments

We thank Emiko Izutsu, Tohoku University Hospital, who assisted in data collection and management.

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Authors and Affiliations

  1. Department of Urology, Tohoku University Graduate School of Medicine, 1-1 Seiryomachi, Aoba-ku, Sendai, 980-8574, Japan

    Shunichi Namiki, Shigeto Ishidoya, Akihiro Ito & Yoichi Arai

  2. Department of Urology, Miyagi Cancer Center, Natori, Japan

    Tatsuo Tochigi

  3. Department of Urology, Osaki Citizen Hospital, Osaki, Japan

    Shunichi Namiki & Isao Numata

Authors
  1. Shunichi Namiki
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  2. Tatsuo Tochigi
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  3. Shigeto Ishidoya
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  4. Akihiro Ito
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  5. Isao Numata
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  6. Yoichi Arai
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Correspondence to Shunichi Namiki.

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Namiki, S., Tochigi, T., Ishidoya, S. et al. Long-term quality of life following primary treatment in men with clinical stage T3 prostate cancer. Qual Life Res 20, 111–118 (2011). https://doi.org/10.1007/s11136-010-9721-6

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  • DOI: https://doi.org/10.1007/s11136-010-9721-6

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