Socio-demographic and clinical determinants of quality of life in Chinese patients with schizophrenia: a prospective study
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The aim of the study was to assess the changes in the quality of life (QOL) of Chinese schizophrenia patients and to identify their predictors over a 1-year follow-up.
A cohort of 116 schizophrenia patients was recruited, and their socio-demographic and clinical characteristics including psychotic and depressive symptoms, drug-induced side effects, social functioning, and QOL were assessed with standardized rating instruments. The patients received standard psychiatric care and were followed up for 1 year.
The psychotic and depressive symptoms, extrapyramidal side effects, and QOL domains of physical functioning, role limitations due to physical problems, social functioning, and role limitations due to emotional problems all improved significantly. Social functioning was a predictor of baseline QOL and change at 1-year follow-up.
Routine clinical management was effective in improving schizophrenia patients’ psychopathology and several domains of QOL. QOL was related to the level of social functioning and had only a weak association with socio-demographic factors.
KeywordsSchizophrenia Quality of life Prospective design Social functioning
Quality of life
Extrapyramidal side effects
Positive and Negative Syndrome Scale
Montgomery-Åsberg Depression Rating Scale
Simpson-Angus Scale of Extrapyramidal Symptoms
Social Disability Screening Schedule
Role limitations due to physical problems
Role limitations due to emotional problems
This study was supported by Direct Grant for Research from the Chinese University of Hong Kong (No. 2041454), the National Natural Science Foundation of China (No. 30800367), the Beijing Nova Program of the Beijing Municipal Science and Technology Commission (No. 2008B59), and the 10th National 5-Year Plan Foundation of the Ministry of Science and Technology Program (No. 2004BA720A22).
- 1.Sartorius, N. (1997). Quality of life, mental disorders: A global perspective. Chichester: John Wiley.Google Scholar
- 7.He, Y. L., & Zhang, M. Y. (1997). The positive and negative syndrome scale (PANSS) and its application (in Chinese). Journal of Clinical Psychiatry, 7, 353–355.Google Scholar
- 10.Wu, W. Y. (1998). Social Disability Screening Schedule-Chinese version. In M. Y. Zhang (Ed.), Handbook of rating scales in psychiatry (pp 163–166). Changsha: Hunan, Hunan Science and Technology Press.Google Scholar
- 11.Xu, J., Hu, M. Y., Yang, Y. B., Wang, B. H., & Xie, Y. N. (1999). Medical outcome study 36 item short form (SF-36) (in Chinese). Chinese Journal of Behavioral Medical Science, 8, 150–152.Google Scholar
- 12.Xu, D., & Xu, D. M. (2001). Investigation of marital status for 758 schizophrenics (in Chinese). Zhongyuan Mental Health, 7, 136–139.Google Scholar
- 13.Guo, Z. Y., Liu, J. M., Zhang, J. Z., Guo, H., & Wang, A. Q. (2008). Efficacy of quetiapine in the treatment of schizophrenic patients and its effect on quality of life (in Chinese). Chinese Journal of Health Psychology, 16, 544–546.Google Scholar
- 14.Potkin, S. G., Weiden, P. J., Loebel, A. D., Warrington, L. E., Watsky, E. J., & Siu, C. O. (2009). Remission in schizophrenia: 196-week, double-blind treatment with ziprasidone vs. haloperidol. International Journal of Neuropsychopharmacology, 12, 1233–1248.Google Scholar
- 15.Wegener, S., Redoblado-Hodge, M. A., Lucas, S., Fitzgerald, D., Harris, A., & Brennan, J. (2005). Relative contributions of psychiatric symptoms and neuropsychological functioning to quality of life in first-episode psychosis. Australian and New Zealand Journal of Psychiatry, 39, 487–492.PubMedGoogle Scholar
- 22.Katschnig, H. (2000). Schizophrenia and quality of life. Acta Psychiatrica Scandinavica, 407(Suppl), 33–37.Google Scholar