The first stage of developing preference-based measures: constructing a health-state classification using Rasch analysis
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To set out the methodological process for using Rasch analysis alongside classical psychometric methods in the development of a health-state classification that is amenable to valuation.
The overactive bladder questionnaire is used to illustrate a five step process for deriving a reduced health-state classification from an existing non-preference-based health-related quality-of-life instrument. Step I uses factor analysis to establish instrument dimensions, step II excludes items that do not meet the initial validation process and step III uses criteria based on Rasch analysis and other psychometric testing to select the final items for the health-state classification. In step IV, item levels are examined and Rasch analysis is used to explore the possibility of reducing the number of item levels. Step V repeats steps I–IV on alternative data sets in order to validate the selection of items for the health-state classification.
The techniques described enable the construction of a five-dimension health-state classification, the OAB-5D, amenable to valuation tasks that will allow the derivation of preference weights.
The health-related quality of life of patients with conditions like overactive bladder can be valued and quality adjustment weights estimated for calculation of quality-adjusted life years.
KeywordsRasch analysis Health-related quality of life Condition-specific measure Preference-based measures Overactive bladder syndrome Quality-adjusted life years
Differential item functioning
Health-related quality of life
Multiatribute utility theory
Overactive bladder syndrome
Overactive bladder questionnaire
Person separation index
Quality-adjusted life years
Standardised response mean
This study is funded by Pfizer Inc. John Brazier is funded by the Medical Research Council Health Service Research Collaboration. Zoe Kopp provided advice throughout the study. The Trial I and Trial II datasets were provided by Pfizer Inc. The usual disclaimer applies.
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