Quality of Life Research

, Volume 17, Issue 2, pp 317–322 | Cite as

Validation of the Japanese version of EORTC QLQ-CR38

  • A. Tsunoda
  • N. Yasuda
  • K. Nakao
  • N. Yokoyama
  • T. Marumori
  • H. Hashimoto
  • M. Kusano
  • K. West
Brief Communcation



The objective of this study was to test the reliability and validity of the Japanese version of the European Organization for Research and Treatment of Cancer (EORTC) Colorectal Cancer-Specific Quality of Life Questionnaire (QLQ-CR38).


The questionnaire was tested among 109 colorectal cancer patients on several occasions. The timing was prior to treatment with radiotherapy or chemotherapy, during treatment and 3 months following the second assessment. For purpose of test–retest reliability, a subgroup of patients completed the QLQ-CR38 1 week following the third assessment.


Multitrait scaling analysis confirmed the hypothesised scale structure of both the function scales and the symptom scales except female sexual problem scale. Cronbach’s alpha coefficients for seven of the nine scales exceeded the 0.7 criterion at one or both assessments. The test–retest reliability for all scales except three symptom scales was 0.67 or higher. On the basis of known-groups comparisons, four of 46 comparisons distinguished between patients differing in disease stage, initial and on-treatment performance status and presence or absence of a stoma. Additionally, these scales detected change over time as a function of change in performance status and treatment-induced change.


These preliminary results suggest that the Japanese EORTC QLQ-CR38 may be a reliable and valid supplementary measure of quality of life in colorectal cancer patients.


Colorectal cancer EORTC QLQ-CR38 Japanese Quality of life Validation study 



The authors wish to thank the EORTC Study Group on Quality of Life for their permission to translate the QLQ-CR38 and for the time spent to approve the translated questionnaire.


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Copyright information

© Springer Science+Business Media B.V. 2007

Authors and Affiliations

  • A. Tsunoda
    • 1
  • N. Yasuda
    • 2
  • K. Nakao
    • 3
  • N. Yokoyama
    • 4
  • T. Marumori
    • 5
  • H. Hashimoto
    • 6
  • M. Kusano
    • 1
  • K. West
    • 7
  1. 1.Department of General and Gastroenterological SurgeryShowa University School of MedicineTokyoJapan
  2. 2.Department of SurgeryIsezaki Municipal HospitalGunmaJapan
  3. 3.Department of SurgeryYamanashi Red Cross HospitalYamanashiJapan
  4. 4.Department of SurgeryShowa University Toyosu HospitalTokyoJapan
  5. 5.Department of SurgeryHitachi Ltd. Mito General HospitalIbarakiJapan
  6. 6.Department of Health Management and PolicyThe University of TokyoTokyoJapan
  7. 7.EORTC Quality of Life UnitBrusselsBelgium

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