Molecular and Biological Functions of Quercetin as a Natural Solution for Cardiovascular Disease Prevention and Treatment


Cardiovascular disease (CVD) is a worldwide health problem with growing up rates of mortality and morbidity. Many risk factors, including high blood pressure, cigarette smoking, diabetes, obesity, and dyslipidemia are responsible for CVD. CVD can be prevented by some simple and cost-effective steps such as smoking cessation, normalizing body weight, regular physical activity, and dietary changes, including decreasing saturated fats, increasing the intake of vegetables and fruits, and reducing sugar intake. In the last decades, growing up number of studies were performed to explain the possible function of non-nutrient substances from the diet which might prevent CVD. One of these natural compounds is quercetin which is widely present in vegetables, tea, fruits and wine. Many in vitro, in vivo and clinical studies have indicated the cardioprotective functions of quercetin. They can be explained by quercetin’s reducing blood pressure, antioxidant potential and some other activities. This review evaluates the experimental and clinical studies that have studied the effect of quercetin in CVD and summarizes the molecular mechanisms of action as well as clinical effects of quercetin in CVD.

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Fig. 1



Cardiovascular disease


World Health Organization


Reactive oxygen species



IFN-γ :


TNF-α :

Tumor necrosis factor-α

TNF-β :

Tumor necrosis factor-β


monocyte chemoattractant protein-1




Vascular cell adhesion molecule-1


Platelet-derived growth factor

TGF-β :

Transforming growth factor-β


Smooth muscle cell


C-reactive protein


Nitric oxide


Superoxide dismutase




Myocardial infarction




Protein carbonyl


Nitrite and nitrate


Inducible nitric oxide synthase




Oxidized glutathione


Toll-like receptors


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ZA contributed in conception, design and drafting of the manuscript.

RS, ZR and LM contributed in data collection and manuscript drafting.

All authors approved the final version for submission.

ZA oversaw the study.

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Correspondence to Rana Shafabakhsh or Zatollah Asemi.

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Mirsafaei, L., Reiner, Ž., Shafabakhsh, R. et al. Molecular and Biological Functions of Quercetin as a Natural Solution for Cardiovascular Disease Prevention and Treatment. Plant Foods Hum Nutr (2020).

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  • Cardiovascular disease
  • Quercetin
  • Signaling pathway
  • Inflammatory markers
  • Metabolic profiles