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Plant Foods for Human Nutrition

, Volume 68, Issue 1, pp 1–10 | Cite as

Anti-inflammatory Properties of Orange Juice: Possible Favorable Molecular and Metabolic Effects

  • Raquel Cristina Lopes Assis Coelho
  • Helen Hermana M. Hermsdorff
  • Josefina Bressan
Original Paper

Abstract

The low-grade inflammation has been recognized as the link between adiposity and the risk of chronic metabolic disorders. Thus, increased concentrations of inflammatory markers, such as interleukins and tumor necrosis factor alpha have been found in obese individuals. In turn, diet can positively or negatively influence on the risk of chronic metabolic diseases by modulating the inflammatory status. In this context, orange juice consumption can play a role in modulation of inflammatory markers through bioactive compounds, such as the flavonoids (hesperidin, naringenin). According to this review, orange juice appears to mediate the inflammatory response in plasma level and gene expression, and in postprandial and chronic (≥7 consecutive days) periods. The current findings suggest that orange juice could be a dietary feature for prevention and treatment of chronic diseases, although more studies are necessary to evaluate the physiological and molecular mechanisms involved.

Keywords

Orange juice Hesperidin Naringenin Inflammation Gene expression Nutrigenomic 

Abbreviations

BP

Blood pressure

CVD

Cardiovascular disease

CD-14

Cluster differentiation 14

CRP

C-reactive protein

COX2

Cyclooxygenase-2

DNA

Deoxyribonucleic acid

DBP

Diastolic blood pressure

FFA

Free fatty acids

GLUT4

Glucose transporter type 4

GST

Glutathione S-transferase

HFHC

High-carbohydrate

IL1R1

IL-1 receptor 1

Iκβ

Inhibitor κβ

ICAM-1

Intercellular adhesion molecule-1

IL

Interleukin

JNK

Janus kinase

LPB

Lipopolysaccharide binding protein

LPS

Lipopolysaccharide

MMP-9

Matrix metalloproteinase-9

METs

Metabolic syndrome

MCP-1

Monocyte chemoattractant protein-1

NRF2

NF-E2-related factor 2

NO

Nitric oxide

NF-κβ

Nuclear factor kappa-B

OJ

Orange juice

PBMC

Peripheral blood mononuclear cells

PAI-1

Plasminogen activator inhibitor-1

QR

Quinone reductase

ROS

Reactive oxygen species

SOCS3

Suppresser of cytokine signaling-3

TLR

Toll-like receptors

TNFα

Tumor necrosis factor alpha

Notes

Conflict of Interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Raquel Cristina Lopes Assis Coelho
    • 1
  • Helen Hermana M. Hermsdorff
    • 1
  • Josefina Bressan
    • 1
  1. 1.Department of Nutrition and HealthyFederal University of ViçosaViçosaBrazil

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