Plant Foods for Human Nutrition

, Volume 67, Issue 1, pp 100–104 | Cite as

Circulating Salicylic Acid and Metabolic and Inflammatory Responses after Fruit Ingestion

  • Samuele Rinelli
  • Angela Spadafranca
  • Giovanni Fiorillo
  • Maurizio Cocucci
  • Simona Bertoli
  • Alberto Battezzati
Original Paper


We hypothesized that fruit ingestion provides measurable amounts of salicylic acid (SA) and produces different metabolic and inflammatory responses compared to mere fruit sugars. In a randomized-crossover study, 26 healthy subjects received a peach shake meal (PSM) (SA: 0,06 ± 0,001 mg/100 g) and a mixed sugar meal (MSM), consisting in an aqueous solution with the same sugars found in the peach shake. In order to control for the SA contribution from meals in the previous day, 16 subjects (Group 1) abstained from fruits and vegetables consumption the evening before trials, and 10 subjects (Group 2) maintained their usual diet. Circulating SA, glucose, insulin, free fatty acids, and interleukin-6 were determined. Basal SA was lower in Group 1 than in Group 2 (0.09 ± 0.02 vs. 0.30 ± 0.03 μmol/l, p < 0.001), peaked at 90 min in both groups (0.18 ± 0.01 vs. 0.38 ± 0.02 μmol/l, p < 0.01) and remained above baseline (p < 0.05) up to 3 h. Glycemia increased less after PSM at 15 min (p < 0.01) with a lower average glucose excursion (p < 0.05). Insulin peaked at 45 min with both meals but decreased less rapidly with PSM. Free fatty acids decreased more (p < 0.01), and interleukin-6 increased less (p < 0.05) with PSM. Dietary fruit intake increases the concentration of SA in vivo, and provides non-nutrients capable to modulate the inflammatory and metabolic responses to carbohydrates.


Fruit ingestion Glucose Inflammation Insulin Salicylic acid 



Acetilsalicylic acid


C reactive protein


Free fatty acids


Fruit and vegetables


Interleukin 6


Mixed sugar meal


Peach shake meal


Salicylic acid


Standard error



This work was supported by grants PRIN from MIUR (n. 2006078852 and 2009SRZRE9) and Università degli Studi di Milano.


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Copyright information

© Springer Science+Business Media, Inc. 2012

Authors and Affiliations

  • Samuele Rinelli
    • 1
  • Angela Spadafranca
    • 1
  • Giovanni Fiorillo
    • 1
  • Maurizio Cocucci
    • 2
  • Simona Bertoli
    • 1
  • Alberto Battezzati
    • 1
  1. 1.Dipartimento di Scienze e Tecnologie Alimentari e Microbiologiche (DiSTAM), International Center for the Assessment of Nutritional Status (ICANS)Università degli Studi di MilanoMilanItaly
  2. 2.Dipartimento di Produzione Vegetale (Di.Pro.Ve)Università degli Studi di MilanoMilanItaly

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