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Plant Foods for Human Nutrition

, Volume 67, Issue 1, pp 94–99 | Cite as

Chemopreventive Effects of Free and Bound Phenolics Associated to Steep Waters (Nejayote) Obtained After Nixtamalization of Different Maize Types

  • Carlos Rojas-García
  • Silverio García-Lara
  • Sergio O. Serna-Saldivar
  • Janet A. Gutiérrez-Uribe
Original Paper

Abstract

Free and bound phenolics extracts from nejayote solids were obtained after optimally lime-cooking blue, normal white, red, normal yellow, high-carotenoid and quality protein maize types. The extraction yield ranged from 4.47 to 10.05%. Bound phenolics extracts had higher content of total phenolics, antioxidant activity and ferulic acid compared to the free phenolics extracts. In general, free phenolics extracts were less cytotoxic than the bound phenolics counterparts. Bound phenolics extracts had higher induction of quinone reductase (QR) and particularly the normal yellow nejayote exerted the highest chemopreventive index tested in Hepa1c1c7 cells. When tested for monofunctional phase 2 induction capacity in BPrc1 cells, the bound phenolics extracts of blue, normal white and quality protein nejayotes were better inducers than the normal yellow counterpart. Particularly, the free phenolics extract of the white maize nejayote induced BPrc1 cells QR and exerted a higher chemopreventive index compared to the bound phenolics extract. Therefore, the nejayote of the normal white maize was the best source of monofunctional phase 2 enzyme inducers.

Keywords

Chemopreventive Wastewater (nejayote) Phenolics Ferulic acid Antioxidant Phase 2 enzymes Monofunctional Bifunctional 

Abbreviations

BLU

blue maize

HCA

high-carotenoid maize

NWH

normal white maize

NYE

normal yellow maize

QPM

quality protein maize

RED

red maize

QR

quinone reductase

ORAC

oxygen radical absorbance capacity

CI

chemopreventive index

CD

concentration for doubling enzymatic activity

Notes

Acknowledgements

This research was supported by the Research Chair Funds CAT-005 from Tecnológico de Monterrey-Campus Monterrey. The six contrasting types of maize were kindly donated by CIMMYT’s Global Maize Program (Batan Experimental Station, Mexico).

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Copyright information

© Springer Science+Business Media, Inc. 2012

Authors and Affiliations

  • Carlos Rojas-García
    • 1
  • Silverio García-Lara
    • 1
  • Sergio O. Serna-Saldivar
    • 1
  • Janet A. Gutiérrez-Uribe
    • 1
  1. 1.Department of Biotechnology and Food EngineeringTEC de Monterrey, ITESM-Campus MonterreyMonterreyMexico

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