Comparative Study on the Chemical Composition, Antioxidant Properties and Hypoglycaemic Activities of Two Capsicum annuum L. Cultivars (Acuminatum small and Cerasiferum)

  • Rosa Tundis
  • Monica R. Loizzo
  • Federica Menichini
  • Marco Bonesi
  • Filomena Conforti
  • Giancarlo Statti
  • Damiano De Luca
  • Bruno de Cindio
  • Francesco Menichini


The present study aimed to evaluate for the first time the phenols, flavonoids, carotenoids, capsaicin and dihydrocapsaicin content and the antioxidant and hypoglycemic properties of Capsicum annuum var. acuminatum small and C. annuum var. cerasiferum air-dried fruits. The ethanol extract of C. annuum var. acuminatum small, characterized by the major content of total poliphenols, flavonoids, carotenoids and capsaicinoids, showed the highest radical scavenging activity (IC50 of 152.9 μg/ml). On the contrary, C. annuum var. cerasiferum showed a significant antioxidant activity evaluated by the β-carotene bleaching test (IC50 of 3.1 μg/ml). The lipophilic fraction of both C. annuum var. acuminatum and C. annuum var. cerasiferum exhibited an interesting and selective inhibitory activity against α-amylase (IC50 of 6.9 and 20.1 μg/ml, respectively).


Capsicum annuum var. acuminatum small C. annuum var. cerasiferum Antioxidant activity α-amylase inhibition α-glucosidase inhibition 







Gas chromatography


Gas chromatography–mass spectrometry


Glucose oxidase peroxidase


Thin layer chromatography



The authors are grateful to Miceli s.r.l. (Italy) for supplying the pepper fruits.


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Rosa Tundis
    • 1
    • 5
  • Monica R. Loizzo
    • 1
  • Federica Menichini
    • 3
  • Marco Bonesi
    • 1
  • Filomena Conforti
    • 1
  • Giancarlo Statti
    • 1
  • Damiano De Luca
    • 4
  • Bruno de Cindio
    • 2
  • Francesco Menichini
    • 1
  1. 1.Department of Pharmaceutical Sciences, Faculty of Pharmacy and Nutrition and Health SciencesUniversity of CalabriaRendeItaly
  2. 2.Department of Engineering ModelingUniversity of CalabriaArcavacata di RendeItaly
  3. 3.AIFA, Italian Medicines AgencyRomaItaly
  4. 4.CALAB, Laboratorio Chimico Merceologico della CalabriaMontalto UffugoItaly
  5. 5.Department of Pharmaceutical Sciences, Faculty of Pharmacy, Nutrition and Health SciencesUniversity of CalabriaRendeItaly

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