The Influences of Whole Brain Radiotherapy on Social Cognition and Association with Hippocampal and Frontal Dosimetry
- 223 Downloads
The influence of brain radiotherapy on neurocognition is a major concern. Social cognition is a mental process in the meaning of social interaction and the recognition of facial emotion is a domain of social cognition. Thus, we aimed to investigate the early effect of whole brain radiotherapy on facial emotion recognition ability. Thirteen patients with various brain tumors in the study. Beck depression and anxiety inventory and the facial emotion recognition test by using a set of photographs were performed at the beginning and post radiotherapy. The severity of depression (16.40 ± 12.16 vs 04.00 ± 02.38 points) and anxiety (14.47 ± 11.96 vs 04.54 ± 03.30 points) were significantly higher in patients. The only significance according to facial emotion recognition rate between initial phase of patients and healthy controls was identifying neutral facial em otion (p = 0.002). The patients after brain radiotherapy had significantly better rate of recognizing fear facial emotions (p = 0.039). This study is the first that investigated the effects of cranial irradiation on facial emotion recognition ability and compares this ability with healthy controls. Interestingly, in the early phase the patients seem to be improved in fear facial emotion after brain radiotherapy without sparing cognition specific regions as hippocampus and frontal regions.
KeywordsBrain radiotherapy Facial emotion recognition Hippocampus Cognition
Conflict of interest
The authors report no conflicts of interest.
- 3.Sperduto PW, Chao ST, Sneed PK, Luo X, Suh J, Roberge D, et al.: Diagnosis-specific prognostic factors, indexes, and treatment outcomes for patients with newly diagnosed brain metastases: a multi-institutional analysis of 4,259 patients. International Journal of Radiation Oncology* Biology* Physics 77(3):655–661, 2010.CrossRefGoogle Scholar
- 15.Brown PD, Pugh S, Laack NN, Wefel JS, Khuntia D, Meyers C, et al.: Memantine for the prevention of cognitive dysfunction in patients receiving whole-brain radiotherapy: a randomized, double-blind, placebo-controlled trial. Neuro-Oncology 15(10):1429–1437, 2013.PubMedCentralCrossRefPubMedGoogle Scholar
- 17.Lautin A: The limbic brain. New york, Springer, 2001.Google Scholar
- 22.Ekman P, Friesen W.(Eds): Pictures of facial affect. Palo Alto, Consulting Psychologists, 1976.Google Scholar
- 26.Hisli N: A study on the validity of Beck Depression Inventory. Turkish Journal of Psychology 6(22):118–123, 1988.Google Scholar
- 28.Ulusoy M, Sahin N, Erkmen H: Turkish version of the Beck Anxiety Inventory: psychometric properties. Journal of Cognitive Psychotherapy 12:163–172, 1998.Google Scholar
- 34.Gray J, Venn H, Montagne B, Murray L, Burt M, Frigerio E, et al.: Bipolar patients show mood-congruent biases in sensitivity to facial expressions of emotion when exhibiting depressed symptoms, but not when exhibiting manic symptoms. Cognitive Neuropsychiatry 11(6):505–520, 2006. doi: 10.1080/13546800544000028.CrossRefPubMedGoogle Scholar
- 35.Csukly G, Telek R, Filipovits D, Takacs B, Unoka Z, Simon L: What is the relationship between the recognition of emotions and core beliefs: Associations between the recognition of emotions in facial expressions and the maladaptive schemas in depressed patients. Journal of Behavior Therapy and Experimental Psychiatry 42(1):129–137, 2011. doi: 10.1016/j.jbtep.2010.08.003.CrossRefPubMedGoogle Scholar
- 39.Dursun P, Emül M, Gençöz F (eds): A review of the literature on emotional facial expression and Its nature, Yeni Symposium, 2010.Google Scholar