Abstract
The Fast Track (FT) intervention was a multimodal preventive intervention addressing antisocial development across 10 years of childhood and early adolescence. The intervention included parent management training, child social-cognitive skills training, peer coaching and mentoring, academic skills tutoring, and a classroom social-emotional learning program. While not specifically designed to target psychosis symptoms (e.g., social withdrawal, thought abnormalities), the present study aimed to examine whether the FT intervention prevented psychosis symptoms through childhood and adolescence and into adulthood. Participants included the FT intervention and high-risk control samples (N = 891; 69% male; M age = 6.58 years, SD = .48). Psychosis symptoms were assessed using the “thought problems” subscale of the parent-report Child Behavior Checklist during grades 1, 2, 4, 5, and 7, and the self-report Adult Behavior Checklist at age 25 years, in line with prior research using this measure. Growth models included the FT condition and covariates (i.e., initial risk screen score, cohort, socioeconomic status, rural/urban status, race, and sex) as predictors; and child, adolescent, and adult psychosis symptoms as outcomes. Intervention status was not significantly associated with the slope of psychosis symptoms; however, after controlling for concurrent cannabis use, intervention participants reported lower levels of psychosis symptoms over time. Findings suggest that interventions targeting antisocial behavior may prevent psychosis symptoms in the long term.
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Notes
Analyses were repeated with grade 1 removed and findings remained the same with the exception of the final model (i.e., whether the FT intervention prevented later psychosis symptoms after controlling for adolescent cannabis use), which no longer provided adequate fit to the data (χ2(104) = 649.879, p < .001, CFI = .382, RMSEA = .078, 90% CI [.072, .084]).
References
Achenbach, T. M. (1991). Manual for the Child Behavior Checklist. Burlington, VT: University of Vermont, Department of Psychiatry.
Achenbach, T. M. (1997). Manual for the Young Adult Self-Report and Young Adult Behavior Checklist. Burlington, VT: University of Vermont Department of Psychiatry.
American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Arlington, VA: American Psychiatric Publishing.
Bagot, K. S., Milin, R., & Kaminer, Y. (2015). Adolescent initiation of cannabis use and early onset psychosis. Substance Abuse, 36, 524–533. https://doi.org/10.1080/08897077.2014.995332.
Bierman, K. L., Greenberg, M. T., Coie, J. D., Dodge, K. A., Lochman, J. E., & McMahon, R. J. (2017). Social and emotional skills training for children: The Fast Track Friendship Group Manual. New York, NY: Guilford Press.
Bor, W., McGee, T. R., Hayatbakhsh, R., Dean, A., & Najman, J. M. (2010). Do antisocial females exhibit poor outcomes in adulthood? An Australian cohort study. Australian & New Zealand Journal of Psychiatry, 44, 648–657. https://doi.org/10.3109/00048671003631159.
Bureau of Labor Statistics, US Department of Labor (2002). National Longitudinal Survey of Youth 1997 Cohort, 1997–2001. Washington, DC: US Department of Labor, Bureau of Labor Statistics.
Conduct Problems Prevention Research Group. (2019). The Fast Track program for children at risk: Preventing antisocial behavior. New York: Guilford Press (in press).
Davies, C., Cipriani, A., Ioannidis, J. P., Radua, J., Stahl, D., Provenzani, U., et al. (2018). Lack of evidence to favor specific preventive interventions in psychosis: A network meta-analysis. World Psychiatry, 17, 196–209. https://doi.org/10.1002/wps.20526.
Dodge, K. A., Godwin, J., & the Conduct Problems Prevention Research Group. (2013). Social-information-processing patterns mediate the impact of preventive intervention on adolescent antisocial behavior. Psychological Science, 24, 456–465. https://doi.org/10.1177/0956797612457394.
Dodge, K. A., Bierman, K. L., Coie, J. D., Greenberg, M. T., Lochman, J. E., McMahon, R. J., & Pinderhughes, E. E. (2015). Impact of early intervention on psychopathology, crime, and well-being at age 25. American Journal of Psychiatry, 172, 59–70. https://doi.org/10.1176/appi.ajp.2014.13060786.
Elliot, D.S., Ageton, S.S., & Huizinga, D. (1985). Explaining delinquency and drug use. Beverly Hills, CA: Siegel.
Garety, P. A., Bebbington, P., Fowler, D., Freeman, D., & Kuipers, E. (2007). Implications for neurobiological research of cognitive models of psychosis: A theoretical paper. Psychological Medicine, 37, 1377–1391. https://doi.org/10.1017/S003329170700013X.
Green, M. F., Penn, D. L., Bentall, R., Carpenter, W. T., Gaebel, W., Gur, R. C., et al. (2008). Social cognition in schizophrenia: An NIMH workshop on definitions, assessment, and research opportunities. Schizophrenia Bulletin, 34, 1211–1220. https://doi.org/10.1093/schbul/sbm145.
Greenberg, M. T., Kusché, C. A., & the Conduct Problems Prevention Research Group. (2011). Grade level PATHS Curriculum. South Deerfield, MA: Channing-Bete.
Hollingshead, A. B. (1975). Four factor index of social status. New Haven, CT: Yale University. Unpublished manuscript
Hu, L., & Bentler, P. M. (1999). Cutoff criteria for fit indexes in covariance structure analysis: Conventional criteria versus new alternatives. Structural Equation Modeling, 6, 1–55. https://doi.org/10.1080/10705519909540118.
IBM Corp. Released. (2013). IBM SPSS Statistics for Windows, Version 22.0. IBM Corp: Armonk, NY.
Jepsen, J. R. M., Fagerlund, B., Pagsberg, A. K., Christensen, A. M. R., Hilker, R. W., Nordentoft, M., & Mortensen, E. L. (2010a). Course of intelligence deficits in early onset, first episode schizophrenia: A controlled, 5-year longitudinal study. European Child & Adolescent Psychiatry, 19, 341–351. https://doi.org/10.1007/s00787-009-0053-4.
Jepsen, J. R. M., Fagerlund, B., Pagsberg, A. K., Christensen, A. M. R., Nordentoft, M., & Mortensen, E. L. (2010b). Deficient maturation of aspects of attention and executive functions in early onset schizophrenia. European Child & Adolescent Psychiatry, 19, 773–786. https://doi.org/10.1007/s00787-010-0126-4.
Kelley, M. E., Wan, C. R., Broussard, B., Crisafio, A., Cristofaro, S., Johnson, S., et al. (2016). Marijuana use in the immediate 5-year premorbid period is associated with increased risk of onset of schizophrenia and related psychotic disorders. Schizophrenia Research, 171, 62–67. https://doi.org/10.1016/j.schres.2016.01.015.
Kim, H. S., Shin, N. Y., Jang, J. H., Kim, E., Shim, G., Park, H. Y., et al. (2011). Social cognition and neurocognition as predictors of conversion to psychosis in individuals at ultra-high risk. Schizophrenia Research, 130, 170–175. https://doi.org/10.1016/j.schres.2011.04.023.
Laruelle, M. (2000). The role of endogenous sensitization in the pathophysiology of schizophrenia: Implications from recent brain imaging studies. Brain Research Reviews, 31, 371–384. https://doi.org/10.1016/S0165-0173(99)00054-5.
Lee, T. Y., Hong, S. B., Shin, N. Y., & Kwon, J. S. (2015). Social cognitive functioning in prodromal psychosis: A meta-analysis. Schizophrenia Research, 164, 28–34. https://doi.org/10.1016/j.schres.2015.02.008.
Marshall, M., Lewis, S., Lockwood, A., Drake, R., Jones, P., & Croudace, T. (2005). Association between duration of untreated psychosis and outcome in cohorts of first-episode patients: A systematic review. Archives of General Psychiatry, 62, 975–983. https://doi.org/10.1001/archpsyc.62.9.975.
McGorry, P. D., Yung, A. R., Phillips, L. J., Yuen, H. P., Francey, S., Cosgrave, E. M., et al. (2002). Randomized controlled trial of interventions designed to reduce the risk of progression to first-episode psychosis in a clinical sample with subthreshold symptoms. Archives of General Psychiatry, 59, 921–928. https://doi.org/10.1001/archpsyc.59.10.921.
Moore, T. H., Zammit, S., Lingford-Hughes, A., Barnes, T. R., Jones, P. B., Burke, M., & Lewis, G. (2007). Cannabis use and risk of psychotic or affective mental health outcomes: A systematic review. The Lancet, 370, 319–328. https://doi.org/10.1016/S0140-6736(07)61162-3.
Morrison, A. P., Stewart, S. L., French, P., Bentall, R. P., Birchwood, M., Byrne, R., et al. (2011). Early detection and intervention evaluation for people at high-risk of psychosis-2 (EDIE-2): Trial rationale, design and baseline characteristics. Early Intervention in Psychiatry, 5, 24–32. https://doi.org/10.1111/j.1751-7893.2010.00254.x.
Morrison, A. P., French, P., Stewart, S. L., Birchwood, M., Fowler, D., Gumley, A. I., et al. (2012). Early detection and intervention evaluation for people at risk of psychosis: Multisite randomised controlled trial. BMJ, 344, e2233. https://doi.org/10.1136/bmj.e2233.
Muthén, B. O., & Muthén, L. K. (2017). Mplus Version 8: User’s guide. Los Angeles, CA: Authors.
Myin-Germeys, I., & van Os, J. (2007). Stress-reactivity in psychosis: Evidence for an affective pathway to psychosis. Clinical Psychology Review, 27, 409–424. https://doi.org/10.1016/j.cpr.206.09.005.
National Institute for Clinical Excellence (NICE). (2009). The NICE guideline on core interventions in the treatment and management of schizophrenia in adults in primary and secondary care—Updated edition. London, U.K.: Author.
Oh, H., & Devylder, J. (2017). Cannabis and psychotic experiences. Addiction, 112, 1688–1689. https://doi.org/10.1111/add.13885.
Pasalich, D. S., Witkiewitz, K., McMahon, R. J., Pinderhughes, E. E., & Conduct Problems Prevention Research Group. (2016). Indirect effects of the Fast Track intervention on conduct disorder symptoms and callous-unemotional traits: Distinct pathways involving discipline and warmth. Journal of Abnormal Child Psychology, 44, 587–597. https://doi.org/10.1007/s10802-015-0059-y.
Patterson, G. R., Forgatch, M. S., & DeGarmo, D. S. (2010). Cascading effects following intervention. Development and Psychopathology, 22, 949–970. https://doi.org/10.1017/S0954579410000568.
Perkins, D. O., Gu, H., Boteva, K., & Lieberman, J. A. (2005). Relationship between duration of untreated psychosis and outcome in first-episode schizophrenia: A critical review and meta-analysis. American Journal of Psychiatry, 162, 1785–1804. https://doi.org/10.1176/appi.ajp.162.10.1785.
Poulton, R., Van Ryzin, M. J., Harold, G. T., Chamberlain, P., Fowler, D., Cannon, M., et al. (2014). Effects of Multidimensional Treatment Foster Care on psychotic symptoms in girls. Journal of the American Academy of Child & Adolescent Psychiatry, 53, 1279–1287. https://doi.org/10.1016/j.jaac.2014.08.014.
Read, J., & Argyle, N. (1999). Hallucinations, delusions, and thought disorder among adult psychiatric inpatients with a history of child abuse. Psychiatric Services, 50, 1467–1472. https://doi.org/10.1176/ps.50.11.1467.
Read, J., Agar, K., Argyle, N., & Aderhold, V. (2003). Sexual and physical abuse during childhood and adulthood as predictors of hallucinations, delusions and thought disorder. Psychology and Psychotherapy: Theory, Research and Practice, 76, 1–22. https://doi.org/10.1348/14760830260569210.
Reef, J., Diamantopoulou, S., van Meurs, I., Verhulst, F., & van der Ende, J. (2010). Predicting adult emotional and behavioral problems from externalizing problem trajectories in a 24-year longitudinal study. European Child & Adolescent Psychiatry, 19, 577–585. https://doi.org/10.1007/s00787-010-0088-6.
Reider, E. E., Robertson, E. B., & Sims, B. E. (2014). Does early intervention prevent health risking sexual behaviors related to HIV/AIDS? Prevention Science, 15, 1–5. https://doi.org/10.1007/s11121-013-0455-x.
Ross, C. A., Anderson, G., & Clark, P. (1994). Childhood abuse and the positive symptoms of schizophrenia. Psychiatric Services, 45, 489–491. https://doi.org/10.1176/ps.45.5.489.
Rubin, D. B., & Little, R. J. (2002). Statistical analysis with missing data. Hoboken, NJ: Wiley.
Savla, G. N., Vella, L., Armstrong, C. C., Penn, D. L., & Twamley, E. W. (2012). Deficits in domains of social cognition in schizophrenia: A meta-analysis of the empirical evidence. Schizophrenia Bulletin, 39, 979–992. https://doi.org/10.1093/schbul/sbs080.
Simeonova, D. I., Attalla, A., Trotman, H., Esterberg, M., & Walker, E. F. (2011). Does a parent-report measure of behavioral problems enhance prediction of conversion to psychosis in clinical high-risk adolescents? Schizophrenia Research, 130, 157–163. https://doi.org/10.1016/j.schres.2011.03.034.
Simeonova, D. I., Nguyen, T., & Walker, E. F. (2014). Psychosis risk screening in clinical high-risk adolescents: A longitudinal investigation using the Child Behavior Checklist. Schizophrenia Research, 159, 7–13. https://doi.org/10.1016/j.schres.2014.07.046.
Stafford, M. R., Jackson, H., Mayo-Wilson, E., Morrison, A. P., & Kendall, T. (2013). Early interventions to prevent psychosis: Systematic review and meta-analysis. BMJ, 346, f185. https://doi.org/10.1136/bmj.f185.
Ujike, H. (2002). Stimulant-induced psychosis and schizophrenia: The role of sensitization. Current Psychiatry Reports, 4, 177–184. https://doi.org/10.1007/s11920-002-0024-7.
van der Gaag, M., van den Berg, D., & Ising, H. (2017). CBT in the prevention of psychosis and other severe mental disorders in patients with an at risk mental state: A review and proposed next steps. Schizophrenia Research. https://doi.org/10.1016/j.schres.2017.08.018.
Vourdas, A., Pipe, R., Corrigall, R., & Frangou, S. (2003). Increased developmental deviance and premorbid dysfunction in early onset schizophrenia. Schizophrenia Research, 62, 13–22. https://doi.org/10.1016/S0920-9964(02)00429-2.
Werthamer-Larsson, L., Kellam, S., & Wheeler, L. (1991). Effect of first-grade classroom environment on shy behavior, aggressive behavior, and concentration problems. American Journal of Community Psychology, 19, 585–602. https://doi.org/10.1007/BF00937993.
Wu, L. T., Brady, K. T., Mannelli, P., Killeen, T. K., & Workgroup, N. I. D. A. A. A. P. I. (2014). Cannabis use disorders are comparatively prevalent among nonwhite racial/ethnic groups and adolescents: A national study. Journal of Psychiatric Research, 50, 26–35. https://doi.org/10.1016/jpsychires.2013.11.010.
Yung, A. R., & Nelson, B. (2013). The ultra-high risk concept—A review. The Canadian Journal of Psychiatry, 58, 5–12. https://doi.org/10.1177/070674371305800103.
Acknowledgments
Members of the Conduct Problems Prevention Research Group, in alphabetical order, are Karen L. Bierman, Pennsylvania State University; John D. Coie, Duke University; D. Max Crowley, Pennsylvania State University; Kenneth A. Dodge, Duke University; Mark T. Greenberg, Pennsylvania State University; John E. Lochman, University of Alabama; Robert J. McMahon, Simon Fraser University and B.C. Children’s Hospital Research Institute; and Ellen E. Pinderhughes, Tufts University.
We are grateful for the collaboration of the Durham Public Schools, the Metropolitan Nashville Public Schools, the Bellefonte Area Schools, the Tyrone Area Schools, the Mifflin County Schools, the Highline Public Schools, and the Seattle Public Schools. We appreciate the hard work and dedication of the many staff members who implemented the project, collected the evaluation data, and assisted with data management and analyses.
Funding
The Fast Track project has been supported by National Institute of Mental Health (NIMH) Grants R18MH48043, R18MH50951, R18MH50952, R18MH50953, R01MH062988, K05MH00797, and K05MH01027; National Institute on Drug Abuse (NIDA) Grants R01DA016903, K05DA15226, RC1DA028248, and P30DA023026; National Institute of Child Health and Human Development Grant R01HD093651; and Department of Education Grant S184U30002. The Center for Substance Abuse Prevention also provided support through a memorandum of agreement with the NIMH. Additional support for this study was provided by a B.C. Children’s Hospital Research Institute Investigator Grant Award and a Canada Foundation for Innovation Award to Robert J. McMahon.
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Drs. Bierman, Coie, Dodge, Greenberg, Lochman, McMahon, and Pinderhughes are the Principal Investigators on the Fast Track Project and have a publishing agreement with Guilford Publications, Inc. Royalties from that agreement will be donated to a professional organization. They are also authors of the PATHS curriculum and donate all royalties from Channing-Bete, Inc. to a professional organization. Dr. Greenberg is a developer of the PATHS curriculum and has a separate royalty agreement with Channing-Bete, Inc. Bierman, Coie, Dodge, Greenberg, Lochman, and McMahon are the developers of the Fast Track curriculum and have publishing and royalty agreements with Guilford Publications, Inc. Dr. McMahon is a coauthor of Helping the Noncompliant Child and has a royalty agreement with Guilford Publications, Inc.
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Goulter, N., McMahon, R.J., Dodge, K.A. et al. Does the Fast Track Intervention Prevent Later Psychosis Symptoms?. Prev Sci 20, 1255–1264 (2019). https://doi.org/10.1007/s11121-019-01041-1
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DOI: https://doi.org/10.1007/s11121-019-01041-1