Plant Molecular Biology

, Volume 82, Issue 6, pp 519–528 | Cite as

Towards systems biological understanding of leaf senescence

  • Yongfeng Guo


The application of systems biology approaches has greatly facilitated the process of deciphering the molecular mechanisms underlying leaf senescence. Analyses of the leaf senescence transcriptome have identified some of the major biochemical events during senescence including protein degradation and nutrient remobilization. Proteomic studies have confirmed these findings and have suggested up-regulated energy metabolism during leaf senescence which might be important for cell viability maintenance. As a critical part of systems biology, studies involving transcription regulation networking and senescence-inducing signaling have deepened our understanding on the molecular regulation of leaf senescence. The important next steps towards a systems biological understanding of leaf senescence will be discussed.


Transcriptome Proteome Protein degradation Nutrient remobilization Networking 



I thank Dr. Susheng Gan at Cornell University for discussion and Dr. Jessica Westbrook at Sandia National Laboratories for critical reading of the manuscript. Research in our lab is supported by a startup fund from the Tobacco Research Institute of Chinese Academy of Agricultural Sciences.


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© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  1. 1.Tobacco Research InstituteChinese Academy of Agricultural SciencesQingdaoChina
  2. 2.Key Laboratory of Tobacco Biology and ProcessingMinistry of AgricultureQingdaoChina

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