Abstract
Background
Personalized postoperative management of patients with pituitary adenomas requires an early risk stratification system.
Methods
We reviewed 501 cases operated between 10/27/2011 and 5/5/2016 by a single neurosurgeon. We determined biochemical remission and tumor resection at 3 months, and biochemical recurrence, tumor recurrence, radiation and reoperation during follow-up. We considered age, gender, tumor diameter, cavernous sinus invasion (CSI) by MRI, diagnostic category (clinical, biochemical and immunohistochemical), and proliferation markers in a Cox proportional hazards model. We built predictive models with the significant parameters and used Kaplan–Meier survival curves for time-dependent analyses.
Results
The 501 cases comprised 141 functional and 360 nonfunctional adenomas. Tumor diameter, CSI, and ki-67 index predicted long-term events. Model 1 (CSI, diameter ≥ 2.9 cm and ki-67 > 3%) identified 18 (3.6%) adenomas and predicted persistent hypersecretory syndrome and residual tumor with 98.7% specificity (OR 8.6; CI 3.0–24.7). Model 2 (ki-67 > 3% and CSI) identified 48 (9.6%) adenomas and had 93.1% specificity (OR 3.3; CI 1.8–6.0). Model 3 (ki-67 > 3%, mitoses and p53, former “atypical” adenoma) identified 26 (5.2%) adenomas and had 96.0% specificity (OR 2.3; CI 1.0–5.0). Model 1 best predicted the long-term event-free survival and was strengthened when Knosp 3–4 CSI grades were used. Model 2 better identified the smaller adenomas at risk. Among the WHO 2017 special PA subtypes, patients with silent corticotroph adenoma had a lower event-free survival than ACTH-negative nonfunctional adenomas.
Conclusion
Use of CSI, ki-67 and tumor diameter in prediction models facilitates tailored surveillance and management of patients with pituitary adenomas.
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Abbreviations
- CSI:
-
Cavernous sinus invasion
- PPV:
-
Positive predictive value
- NPV:
-
Negative predictive value
- SD:
-
Standard deviation
- CD:
-
Cushing’s disease
- ACM:
-
Acromegaly
- NFA:
-
Non-functional adenoma
- SCA:
-
Silent ACTH-positive adenoma
- ACTH:
-
Adrenocorticotropic hormone
- PA:
-
Pituitary adenomas
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Emilee Wehunt, research coordinator responsible for regulatory aspects pertaining to this study.
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Pappy, A.L., Savinkina, A., Bicknese, C. et al. Predictive modeling for pituitary adenomas: single center experience in 501 consecutive patients. Pituitary 22, 520–531 (2019). https://doi.org/10.1007/s11102-019-00982-8
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DOI: https://doi.org/10.1007/s11102-019-00982-8