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Static and dynamic balances of patients with acromegaly and impact of exercise on balance

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Abstract

Purpose

Patients with acromegaly may have balance abnormalities due to changes in body composition. We aim to compare static and dynamic balances in patients with acromegaly and healthy volunteers, and to evaluate the effects of exercise on balance in patients with acromegaly.

Methods

This prospective study included 25 patients with acromegaly followed at endocrinology clinic of Cerrahpasa Medical Faculty and 13 healthy volunteers. The acromegalic patients were divided into 2 groups. Group A (n = 11) attended an exercise program 3 days/week for 3 months, whereas group B (n = 14) and healthy volunteers (Group C) were exercise-free. Bipedal and unipedal stance static and dynamic balance tests were performed using a Prokin 252N device.

Results

The ages, demographic characteristics, and body compositions were similar. In acromegalic patients, the static balance parameters of displacement of center-of-pressure in anterior–posterior direction (C.o.P.Y) while eyes open (p = 0.002) and on left leg (p = 0.001), in left–right direction (C.o.P.X) on right leg (p = 0.03), eyes-closed average medio-lateral velocity (AMLV) (p = 0.001) and the dynamic parameter of forward/backward front/right standard deviation (FBFRSD) (p = 0.02) were significantly different from healthy controls. When the exercise effect on balance was evaluated between group A and B, there were significant improvements in most parameters of dynamic balance measurements of both forward–backward and medial–lateral sway (FBFRSD, FBDME, and RLBLSD) (p = 0.02, p = 0.02, and p = 0.004, respectively) after exercise in group A.

Conclusions

Patients with acromegaly had impairments at various static and dynamic balance parameters, especially in posterior direction. After a 3-month exercise program, the dynamic balance profoundly improved, but static balance was relatively preserved in patients with acromegaly.

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Fig. 1

Adopted from software Prokin 5.0 operator’s manual

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Acknowledgements

We thank Mr. David F. Chapman for his help regarding English language editing.

Funding

The study was supported by the Research Fund of Istanbul University, Istanbul, Turkey (Project No: 22561).

Author information

Authors and Affiliations

  1. Division of Endocrinology-Metabolism and Diabetes, Department of Internal Medicine, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Istanbul, Turkey

    Ozlem Haliloglu, Ozge Polat Korkmaz, Serdar Sahin & Pinar Kadioglu

  2. Department of Sport Health and Science, School of Physical Education and Sports, Marmara University, Istanbul, Turkey

    Nuri Topsakal, Filiz Camliguney, Birol Cotuk & Oya Erkut

Authors
  1. Ozlem Haliloglu
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  2. Nuri Topsakal
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  3. Filiz Camliguney
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  4. Ozge Polat Korkmaz
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  5. Serdar Sahin
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  6. Birol Cotuk
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  7. Pinar Kadioglu
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Correspondence to Pinar Kadioglu.

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Human and animal rights

The study was approved by the local ethics committee of Istanbul University Cerrahpasa Medical Faculty and all procedures performed in studies involving human participants were conducted in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Haliloglu, O., Topsakal, N., Camliguney, F. et al. Static and dynamic balances of patients with acromegaly and impact of exercise on balance. Pituitary 22, 497–506 (2019). https://doi.org/10.1007/s11102-019-00979-3

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