, Volume 20, Issue 1, pp 63–69 | Cite as

Acromegalic osteopathy

  • G. Mazziotti
  • F. Maffezzoni
  • S. Frara
  • A. Giustina


Acromegalic osteopathy is an emerging complication of acromegaly characterized by increase in bone turnover, deterioration in bone microarchitecture and high risk of vertebral fractures. Vertebral fractures, as diagnosed by a radiological and morphometric approach, occur in about one-third of acromegaly patients in close relationship with duration of active disease. However, the prediction of vertebral fractures in this clinical setting is still a matter of uncertainty, since the pathogenesis of acromegalic osteopathy is multifactorial and fractures may occur even in presence of normal bone mineral density. In this narrative article, we summarize the pathophysiology and clinical aspects of acromegalic osteopathy.


Acromegaly Fractures Osteoporosis Growth hormone IGF-I 



This study was partially supported by GIOSEG.

Compliance with ethical standards

Conflict of interest

G.M. received consultant fees from Novartis Farma and Ipsen and received lecture fee from Ipsen. A.G. is a consultant for Ipsen, Novartis, and Pfizer. F.M. and S.F. have nothing to disclose.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.


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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • G. Mazziotti
    • 1
    • 2
  • F. Maffezzoni
    • 1
  • S. Frara
    • 1
  • A. Giustina
    • 1
  1. 1.Chair of EndocrinologyUniversity of BresciaBresciaItaly
  2. 2.Endocrinology UnitASST Carlo Poma of MantuaMantuaItaly

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