Pituitary adenoma with gangliocytic component: report of 5 cases with focus on immunoprofile of gangliocytic component
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Pituitary adenomas with gangliocytic component are rare tumors of the sellar region that are composed of pituitary adenoma cells and a ganglion cell component. Their histogenesis and hence nosology is not yet resolved because of the small number of cases reported and lack of large series in the literature.
Herein we report five cases of pituitary adenoma with gangliocytic component to add knowledge to this rare neoplasm.
Three cases are functional mammosomatotroph adenomas, one case is functional sparsely granulated somatotroph adenoma and the other is functional corticotroph adenoma. Gangliocytic component showed immunohistochemical expression of hormones in three cases. The ganglion cells were prolactin immunoreactive in case 1, GH and TSH immunoreactive in case 5 and showed expression of prolactin, TSH, ACTH and FSH in case 4. Three cases had undergone more than one surgery of which two had gangliocytic cells only in the recurrent tumors whereas the third case showed gangliocytic cells only in the initial tumor.
The cases are discussed with clinical and histological features and a brief review of the literature considering the histogenesis is included.
KeywordsPituitary adenoma with gangliocytic component Gangliocytoadenoma Gangliocytoma Pituitary adenoma Anterior pituitary tumors
Some of these cases were presented in the 13th Meeting of the European Neuroendocrine Association (17–20 October 2008 Antalya/Turkey) and the 18th National Pathology Congress of the Turkish Pathology Association (25–29 October 2008 Antalya/Turkey) as posters.
Conflict of interest
The authors declare no conflict of interest.
- 1.Asa SL, Sano T, Kovacs K, Lloyd RV, Trouillas J (2004) Gangliocytoma. In: DeLellis RA, Heitz PU, Eng C (eds) WHO classification of tumours of the endocrine organs: pathology and genetics of endocrine organs. IARC Press, Lyon, p 40Google Scholar
- 15.Jackson P, Blythe D (2012) Strept avidin-biotin techniques. In: Suvarna KS, Layton C, Bancroft JD (eds) Bancroft’s theory and practice of histological techniques. Churchill Livingstone, London, p 389Google Scholar
- 20.Morikawa M, Tamaki N, Kokunai T, Imai Y (1997) Intrasellar pituitary gangliocyto-adenoma presenting with acromegaly: case report. Neurosurgery 40(3): 611–614; discussion 614-615Google Scholar
- 23.Asa SL, Scheithauer BW, Bilbao JM, Horvath E, Ryan N, Kovacs K, Randall RV, Laws ER Jr, Singer W, Linfoot JA et al (1984) A case for hypothalamic acromegaly: a clinicopathological study of six patients with hypothalamic gangliocytomas producing growth hormone-releasing factor. J Clin Endocrinol Metab 58(5):796–803PubMedCrossRefGoogle Scholar
- 26.Puchner MJ, Ludecke DK, Valdueza JM, Saeger W, Willig RP, Stalla GK, Odink RJ (1993) Cushing’s disease in a child caused by a corticotropin-releasing hormone-secreting intrasellar gangliocytoma associated with an adrenocorticotropic hormone-secreting pituitary adenoma. Neurosurgery 33(5): 920–924; discussion 924–925Google Scholar