, Volume 17, Issue 5, pp 441–449 | Cite as

Prevalence of obstructive sleep apnea in patients with prolactinoma before and after treatment with dopamine agonists

  • Flávia Regina Pinho Barbosa
  • Cintia Marques dos Santos Silva
  • Giovanna Aparecida Balarinni Lima
  • Leila Warszawski
  • Romeu Cortes Domingues
  • Michele Dominic
  • Rosita Fontes
  • Leonardo Vieira Neto
  • Mônica Roberto Gadelha



Obesity is the main risk factor for the development of obstructive sleep apnea (OSA). Hyperprolactinemia has also been related to obesity. To determine the OSA prevalence in patients with prolactinoma before and after dopamine agonist (DA) and to evaluate the correlation between the apnea-hypopnea index (AHI) and prolactin levels, body mass index (BMI), waist circumference (WC), visceral fat volume (VFV), subcutaneous fat volume, and other metabolic parameters.


Thirty-five patients with prolactinoma at baseline and twenty-one who completed the 6-month DA treatment were submitted to clinical/laboratorial evaluations, polysomnography and abdominal imaging.


Before treatment, the prevalence of obesity/overweight and OSA were, respectively, 68.5 and 34.2 %. We found a positive correlation between AHI and weight (r = 0.57; p < 0.001), BMI (r = 0.56; p < 0.001), WC (r = 0.61; p < 0.001), VFV (r = 0.55; p = 0.002), insulin levels (r = 0.57; p < 0.001), and HOMA-IR index (r = 0.57; p < 0.001); and a negative correlation between AHI and HDL-cholesterol (r = −0.47; p = 0.005). After multivariate analysis, VFV and insulin levels were the most important predictors for AHI (p = 0.001 and p = 0.02, respectively). After DA, the obesity/overweight and OSA prevalence did not change.


The OSA prevalence in patients with prolactinoma is similar to the obese subjects and did not change after treatment. Higher BMI and visceral obesity, but not prolactin levels, seem to be the major factor involved in the occurrence of OSA in these patients.


Prolactinoma Obstructive sleep apnea Hyperprolactinemia Dopamine agonist 


Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Flávia Regina Pinho Barbosa
    • 1
    • 2
  • Cintia Marques dos Santos Silva
    • 1
  • Giovanna Aparecida Balarinni Lima
    • 3
  • Leila Warszawski
    • 1
    • 4
  • Romeu Cortes Domingues
    • 5
  • Michele Dominic
    • 6
  • Rosita Fontes
    • 7
  • Leonardo Vieira Neto
    • 1
    • 8
  • Mônica Roberto Gadelha
    • 1
  1. 1.Department of Internal Medicine and Endocrine Unit, Medical School and Clementino Fraga Filho University HospitalFederal University of Rio de JaneiroRio de JaneiroBrazil
  2. 2.Division of EndocrinologyUniversidade Federal do Estado do Rio de JaneiroRio de JaneiroBrazil
  3. 3.Endocrinology Unit, Internal Medicine DepartmentUniversidade Federal FluminenseRio de JaneiroBrazil
  4. 4.Division of EndocrinologyInstituto Estadual de Diabetes e Endocrinologia Luiz CapriglioneRio de JaneiroBrazil
  5. 5.Clínica Multi-Imagem/Clínica de Diagnóstico por ImagemRio de JaneiroBrazil
  6. 6.Clínica Neurológica Professor Fernando PompeuRio de JaneiroBrazil
  7. 7.Laboratório Diagnóstico da AméricaRio de JaneiroBrazil
  8. 8.Endocrinology SectionFederal Hospital of LagoaRio de JaneiroBrazil

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