, 12:304 | Cite as

Effects of physical training on serum and pituitary growth hormone contents in diabetic rats

  • José Alexandre Curiacos de Almeida Leme
  • Michel Barbosa de Araújo
  • Leandro Pereira de Moura
  • Ricardo José Gomes
  • Rodrigo Ferreira de Moura
  • Gustavo Puggina Rogatto
  • Maria Alice Rostom de Mello
  • Eliete Luciano


The present study investigated the effects of moderate physical training on some of the parameters in the GH-IGF axis in experimental diabetic rats. Male Wistar rats were allocated into the following groups: sedentary control, trained control, sedentary diabetic, trained diabetic. Diabetes was induced by alloxan (32 mg/kg, b.w. iv). The physical training protocol consisted of 1 h swimming session/day, 5 days/week for 8 weeks supporting a load corresponding to 90% of maximal lactate steady state. After the experimental period, blood was collected to measure serum glucose, insulin, triglycerides, albumin, insulin-like growth factors-I (IGF-I), and growth hormone (GH). Pituitary gland was removed for GH quantification. Diabetes increased blood glucose and triglycerides and decreased insulin, IGF-I, serum and pituitary GH. Physical training decreased glucose and triglycerides, and also counteracted the reduction of serum IGF-I in diabetic rats. In conclusion, physical training recovered serum IGF-I showing no alteration of serum or pituitary GH levels.


Pituitary Physical training Diabetes Growth hormone and IGF 


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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • José Alexandre Curiacos de Almeida Leme
    • 1
  • Michel Barbosa de Araújo
    • 1
  • Leandro Pereira de Moura
    • 1
  • Ricardo José Gomes
    • 1
  • Rodrigo Ferreira de Moura
    • 1
  • Gustavo Puggina Rogatto
    • 1
  • Maria Alice Rostom de Mello
    • 1
  • Eliete Luciano
    • 1
  1. 1.Department of Physical EducationSão Paulo State University (UNESP)Bela Vista, Rio ClaroBrazil

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