, Volume 14, Issue 4, pp 345–350 | Cite as

Sellar and suprasellar mixed germ cell tumor mimicking a pituitary adenoma

  • Luiz Eduardo Armondi Wildemberg
  • Leonardo Vieira Neto
  • Giselle Fernandes Taboada
  • Aline Barbosa Moraes
  • Jorge Marcondes
  • Flávia Lúcia Conceição
  • Leila Chimelli
  • Mônica Roberto Gadelha
Case Report


Germ cell tumors (GCT) are a heterogeneous group of lesions whose origin is not well established. Several cases of primary intrasellar germinomas have been reported, however non-germinomatous GCT have rarely been described. We report the case of a young adult male patient with a mixed GCT that presented with a sellar tumor with suprasellar extension. The patient seeked medical attention because of seizures and magnetic resonance imaging evidenced a tumor of the sellar region. Hyperprolactinemia was also present and dopamine agonist therapy was started. As there was a rapid tumor growth and the patient had concomitant central diabetes insipidus and elevated testosterone levels, a GCT was suspected and confirmed by elevated serum concentration of β-human chorionic gonadotrophin. Patient underwent surgical resection of the tumor and histopathological examination confirmed the diagnosis of a mixed GCT. Chemotherapy was initiated, followed by conventional radiotherapy. In conclusion, although pituitary adenomas respond for the vast majority of sellar tumors, concomitant symptoms such as central diabetes insipidus and rapid tumor growth should raise the suspicion of a diverse diagnosis. The present report intend not only to show a rare case of sellar and suprasellar mixed GCT but also to remind clinicians that if laboratory findings do not fit into patient’s diagnosis (such as high testosterone levels in our patient), then the diagnosis should be reviewed.


Mixed germ cell tumors Intrasellar Pituitary adenoma Central diabetes insipidus β-Human chorionic gonadotrophin 


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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Luiz Eduardo Armondi Wildemberg
    • 1
  • Leonardo Vieira Neto
    • 1
  • Giselle Fernandes Taboada
    • 1
  • Aline Barbosa Moraes
    • 1
    • 2
  • Jorge Marcondes
    • 3
  • Flávia Lúcia Conceição
    • 1
  • Leila Chimelli
    • 4
  • Mônica Roberto Gadelha
    • 1
    • 2
  1. 1.Endocrinology Unit, Hospital Universitário Clementino Fraga FilhoUniversidade Federal do Rio de Janeiro (UFRJ)Rio de JaneiroBrazil
  2. 2.Endocrinology UnitInstituto Estadual de Diabetes e Endocrinologia Luiz Capriglione do Rio de Janeiro (IEDE-RJ)Rio de JaneiroBrazil
  3. 3.Neurosurgery Unit, Hospital Universitário Clementino Fraga FilhoUniversidade Federal do Rio de Janeiro (UFRJ)Rio de JaneiroBrazil
  4. 4.Pathology Unit, Hospital Universitário Clementino Fraga FilhoUniversidade Federal do Rio de Janeiro (UFRJ)Rio de JaneiroBrazil

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