, Volume 11, Issue 1, pp 85–87 | Cite as

An unusual association of a sellar gangliocytoma with a prolactinoma

  • Omar Serri
  • France Berthelet
  • Manon Bélair
  • Sophie Vallette
  • Sylvia L. Asa
Case Report


The simultaneous occurrence of a hypothalamic and sellar gangliocytoma with a pituitary prolactinoma is very rare. The explanation for such an association is not known. We describe the case of a woman who had a coexisting adjacent pituitary prolactinoma and gangliocytoma within the same sellar mass. The tumor cells of the gangliocytoma demonstrated expression of enkephalin, a product of proopiomelanocortin known to be a prolactin secretagogue. We postulate that in this patient there may be a link between gangliocytoma enkephalin and prolactin hypersecretion.


Prolactinoma Gangliocytoma Pituitary 


  1. 1.
    Geddes JF, Jansen GH, Robinson SF et al (2000) Gangliocytomas of the pituitary: a heterogeneous group of lesions with differing histogenesis. Am J Surg Pathol 24:607–613 Medline. doi:10.1097/00000478-200004000-00017Google Scholar
  2. 2.
    Towfighi J, Salam MM, McLendon RE, Powers S, Page RB (1996) Ganglion cell-containing tumors of the pituitary gland. Arch Pathol Lab Med 120:369–377PubMedGoogle Scholar
  3. 3.
    Puchner MJA, Hermann HD (1998) Intrasellar pituitary gangliocytoma presenting with acromegaly: case report. Neurosurgery 42:1197–1199. letter Medline. doi:10.1097/00006123-199805000-00165Google Scholar
  4. 4.
    Asada H, Otani M, Furuhata S, Inoue H, Toya S, Ogawa Y (1990) Mixed pituitary adenoma, gangliocytoma associated with acromegaly. Neurol Med Chir (Tokyo). 30:628–632 MedlineGoogle Scholar
  5. 5.
    McCowen K, Glickmann JN, Black PM, Zervas NT, Lidov HGW, Garber JR (1999) Gangliocytoma masquerading as a prolactinoma. J Neurosurg 91:490–495 MedlineGoogle Scholar
  6. 6.
    Li JY, Racadot O, Kujas M, Kouadri M, Peillon F, Racadot J (1989) Immunocytochemistry of four mixed pituitary adenomas and intrasellar gangliocytomas associated with different clinical syndromes: acromegaly, amenorrhea-galactorrhea, Cushing’s disease and isolated tumoral syndrome. Acta Neuropathol (Berl) 77:320–328 Medline. doi:10.1007/BF00687585Google Scholar
  7. 7.
    Asa SL, Sheithauer BW, Bilbao JM et al (1984) A case for hypothalamic acromegaly: a clinico-pathological study of six patients with hypothalamic gangliocytomas producing growth hormone-releasing factor. J Clin Endocrinol Metab 58:796–802 MedlineGoogle Scholar
  8. 8.
    Molitch M. Pharmacologic resistance in prolactinoma patients (2005) Pituitary 8:43–52 Medline. doi:10.1007/s11102-005-5085-2Google Scholar

Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Omar Serri
    • 1
  • France Berthelet
    • 1
  • Manon Bélair
    • 1
  • Sophie Vallette
    • 1
  • Sylvia L. Asa
    • 2
  1. 1.Departments of Medicine, Radiology and Pathology, CHUM Notre-Dame HospitalUniversity of MontrealMontrealCanada
  2. 2.University Health Network, University of TorontoTorontoCanada

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