, Volume 9, Issue 3, pp 267–273 | Cite as

Pituitary abscess: Report of four cases and review of literature

  • Pinaki Dutta
  • Anil Bhansali
  • Paramjeet Singh
  • Narendra Kotwal
  • Ashish Pathak
  • Yashwant Kumar
Case Report and Literature Review


Pituitary abscess is a rare disorder and its presenting manfestations are non-specific therefore, the diagnosis is usually made either postoperatively or at postmortem. We describe four such cases seen over a period of 10 years. All the patients presented with fever, systemic signs of toxaemia and endocrine dysfunctions. Two of them had pre-existing pituitary pathology. A preoperative diagnosis of pituitary abscess was considered in all in view of characteristic MR findings. Three patients underwent transsphenoidal drainage of abscess, whereas the remaining one succumbed to sepsis and was diagnosed at necropsy. Offending organisms including Pseudomonas, Acinetobacter and Staphylococcus were isolated in three cases respectively. During follow-up for 4 years, 2 patients are doing well, one had a recurrent abscess after 1 year and required redo-surgery.

Key words

Hypopituitarism Pituitary abscess Toxaemia 


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  1. 1.
    Simmonds M (1914) zur pathologic der hypophysis. Verh Disch Pathol 17:208–212Google Scholar
  2. 2.
    Vates GE, Berger MS, Wilson CB (2001) Diagnosis and management of pituitary abscess: A review of twenty-four cases. J Neurosurg 95:233–241PubMedGoogle Scholar
  3. 3.
    Wilson CB, Boggan JE (1985) Pituitary abscess. In: Wilkins RH, Rengachary SS (eds), Neurosurgery, McGraw-Hill Book Company, London 1967–1969Google Scholar
  4. 4.
    Jain KC, Varma A, Mahapatra AK (1997) Pituitary abscess: A series of six Cases. Br J Neurosurg 11:139–142PubMedCrossRefGoogle Scholar
  5. 5.
    Ahmed YS, Bradey N, Halaka AN, Belchetz PE, Ironside JW (1989) Primary pituitary abscess: Surgical management and endocrine assessment in three cases. Br J Neurosung 3:409–414Google Scholar
  6. 6.
    Kimura H, Fukushima T, Matsuda T et al. (1994) Abscess formation in a Rathke’s cleft cyst No To Shinkee 46:392–395Google Scholar
  7. 7.
    Obrador S, Balazquez MG (1972) Pituitary abscess in a craniopharyngioma. J Neurosurg 36:785–789PubMedGoogle Scholar
  8. 8.
    Nelson PB, Haverkos H, Mertinez AJ et al (1983) Abscess formation within pituitary tumors. Neurosurgery 12:331–333PubMedGoogle Scholar
  9. 9.
    Becker GL Jr., Knep S, Lance KP et al. (1980) Amoebic abscess of the brain. Neurosurgery 6:192–194PubMedGoogle Scholar
  10. 10.
    Heary RF, Maniker AH, Wolnasky LJ (1995) Candidal pituitary abscess: Case report. Neurosurgery 36:1009–1013PubMedGoogle Scholar
  11. 11.
    Ramos - Gabatin A, Jordan RM (1981) Primary pituitary aspergillosis responding to transsphenoidal surgery and combined therapy with amphotericin B and 5- fluorocytosine J. Neurosurg 54:839–841Google Scholar
  12. 12.
    Maartens NF, Ellegala DB, Lopes MB (2001) Pituitary abscess. J Neurosurg 95:110–112Google Scholar
  13. 13.
    Bossard D, Himed A, Badet C et al (1992) MRI and CT in a case of pituitary abscess. J Neuroradiol 19:139–149PubMedGoogle Scholar
  14. 14.
    Wolansky LJ, Gallagher JD, Heary RF et al (1992) MRI of pituitary abscess: Two cases and review of literature. Neuroradiology 39:499–503CrossRefGoogle Scholar
  15. 15.
    Sahjpaul RL, Lee DH (1999) Infratentorial subdural empyema, pituitary abscess and septic cavernous sinus thrombophlebitis secondary to paranasal sinusitis: Case report Neurosurgery 44:864–868.PubMedCrossRefGoogle Scholar
  16. 16.
    Hanel RA, Koerbel A, Prevedello DM, Moro MS, Araiyo JC (2002) Primary Pituitary abscess Arquivos de Neuro-psiquiatria. 60:1–7Google Scholar
  17. 17.
    Metellus P, Levrier O, Grisoli F (2002) Abscess-like formation concomittant with pituitary adenoma in Cushing’s disease: Case report and pathological considerations. Br J Neurosurg 16:373–375PubMedCrossRefGoogle Scholar
  18. 18.
    Domingue JN, Wilson CB (1977) Pituitary abscess. Report of seven cases and review of the literature. J Neurosurg 46:601–608PubMedCrossRefGoogle Scholar
  19. 19.
    Martines F, Scarano P, Chiappetta E et al (1996) Pituitary abscess. A case report and review of the literature. J Neurosurg Sc 90:135–138Google Scholar

Copyright information

© Springer Science + Business Media, LLC 2006

Authors and Affiliations

  • Pinaki Dutta
    • 1
  • Anil Bhansali
    • 1
  • Paramjeet Singh
    • 2
  • Narendra Kotwal
    • 3
  • Ashish Pathak
    • 4
  • Yashwant Kumar
    • 5
  1. 1.Department of EndocrinologyPost Graduate Institute of Medical Education and ResearchChandigarhIndia
  2. 2.Department of RadiodiagnosisPostgraduate Institute of Medical Education and ResearchChandigarhIndia
  3. 3.Research and Referrral HospitalNew DelhiIndia
  4. 4.Department of NeurosurgeryPostgraduate Institute of Medical Education and ResearchChandigarhIndia
  5. 5.Department of HistopathologyPostgraduate Institute of Medical Education and ResearchChandigarhIndia

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