Skip to main content
SpringerLink
Log in

Chemistry and medicinal uses of the subfamily Barnadesioideae (Asteraceae)

  • Published:
Phytochemistry Reviews Aims and scope Submit manuscript

Abstract

The subfamily Barnadesioideae (Asteraceae) constitutes a group of spiny plants that are entirely restricted to South America and currently encompasses 92 species distributed in nine genera. Barnadesioideae is particularly interesting because this subfamily constitutes the sister group of all other Asteraceae, and provides insights into the early evolution of Asteraceae. The present work summarizes the current knowledge of the chemistry and medicinal uses of Barnadesioideae. The up-to-date phytochemical profile of Barnadesioideae is composed of phenolic compounds, flavonoids, and triterpenoids, representing 39 different compounds described in 45 species of the subfamily. The presumable absence of sesquiterpene lactones—the typical Asteraceae taxonomical markers—in members of Barnadesioideae is also discussed. A few members of the genera Barnadesia, Dasyphyllum, and more frequently, Chuquiraga, are reported in the traditional medicine of Argentina, Brazil, Bolivia, Chile, Colombia, Ecuador, and Peru, where they are known for their antitussive, expectorant, anti-inflammatory, and many other properties. Chuquiraga jussieui, Chuquiraga spinosa, and Chuquiraga weberbaueri are species frequently sold in medicinal plant markets of Ecuador and Peru, where they are commonly recommended for the relief of genitourinary and reproductive disorders in women and men. Some phytopharmaceuticals containing C. spinosa are also marketed in Europe and North America. Further phytochemical studies on the members of Barnadesioideae would be of great interest for the chemotaxonomy of the family Asteraceae. Moreover, profiling the phytochemical composition of those medically important Barnadesioideae would support their uses in traditional medicine.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  • Abad C, González J, Chamorro A (2009) El Apu Pariacaca y el Alto Cañete: Estudio de paisaje cultural. Instituto Nacional de Cultura, Lima

    Google Scholar 

  • Alberto MR, Zampini IC, Isla MI (2009) Inhibition of cyclooxygenase activity by standardized hydroalcoholic extracts of four Asteraceae species from the Argentine Puna. Braz J Med Biol Res 42:787–790

    Article  CAS  PubMed  Google Scholar 

  • Anderson H (1867) Notes on some of the Compositae of the Andes, and more particularly on Chuquiraga insignis. Trans Proc Bot Soc Edinb 9:115–118

    Google Scholar 

  • Ansaloni R, Wilches I, León F et al (2010) Estudio preliminar sobre plantas medicinales utilizadas en algunas comunidades de las provincias de Azuay, Cañar y Loja, para afecciones del aparato gastrointestinal. Revista Tecnológica ESPOL 23:89–97

    Google Scholar 

  • Arroyo-Acevedo J, Herrera-Calderón O, Chávez-Asmat R et al (2017) Protective effect of Chuquiraga spinosa extract on N-methyl-nitrosourea (NMU) induced prostate cancer in rats. Prostate Int 5:47–52

    Article  PubMed  PubMed Central  Google Scholar 

  • Barbarán FR (2008) Medicinal plants of the Argentinean Puna: a common property resource and an opportunity for local people. In: Proceedings of the twelfth biennial conference of the international association for the study of commons. Indiana University, Cheltenham, 14–18 July 2008

  • Bohlmann F, Zdero C, Schmeda-Hirschmann G et al (1986) Dimeric guaianolides and other constituents from Gochnatia species. Phytochemistry 25:1175–1178

    Article  CAS  Google Scholar 

  • Bohm BA, Stuessy TF (1995) Flavonoid chemistry of Barnadesioideae (Asteraceae). Syst Bot 20:22–27

    Article  Google Scholar 

  • Bohm BA, Stuessy TF (2001) Flavonoids of the sunfower family (Asteraceae). Springer, Wien

    Book  Google Scholar 

  • Brack A (1999) Diccionario enciclopédico de plantas útiles del Perú. Centro Bartolomé de Las Casas, Cusco

    Google Scholar 

  • Bremer K, Jansen RK (1992) A new subfamily of the Asteraceae. Ann Mo Bot Gard 79:414–415

    Article  Google Scholar 

  • Buitron XC (1999) Ecuador: uso y comercio de pantas medicinales, situación actual y aspectos importantes para su conservación. TRAFFIC International, Cambridge

    Google Scholar 

  • Bussmann RW, Glenn A (2010) Medicinal plants used in Northern Peru for reproductive problems and female health. J Ethnobiol Ethnomed 6:30

    Article  PubMed  PubMed Central  Google Scholar 

  • Bussmann RW, Sharon D (2006a) Traditional plant use in Northern Peru: tracking two thousand years of healing culture. J Ethnobiol Ethnomed 2:47

    Article  PubMed  PubMed Central  Google Scholar 

  • Bussmann RW, Sharon D (2006b) Traditional medicinal plant use in Loja province, Southern Ecuador. J Ethnobiol Ethnomed 2:44

    Article  PubMed  PubMed Central  Google Scholar 

  • Bussmann RW, Sharon D (2015) Medicinal plants of the Andes and the Amazon—the magic and medicinal flora of Northern Peru. William L. Brown Center, St. Louis

    Google Scholar 

  • Bussmann RW, Sharon D, Vandebroek I et al (2007) Health for sale: the medicinal plant markets in Trujillo and Chiclayo, Northern Peru. J Ethnobiol Ethnomed 3:37

    Article  PubMed  PubMed Central  Google Scholar 

  • Bussmann RW, Sharon D, Perea FA et al (2008) Antibacterial activity of Northern-Peruvian medicinal plants. Arnaldoa 15:127–148

    Google Scholar 

  • Bussmann RW, Glenn A, Meyer K et al (2010) Herbal mixtures in traditional medicine in Northern Peru. J Ethnobiol Ethnomed 6:10

    Article  PubMed  PubMed Central  Google Scholar 

  • Bussmann RW, Malca G, Glenn A et al (2011) Toxicity of medicinal plants used in traditional medicine in Northern Peru. J Ethnopharmacol 137:121–140

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bussmann RW, Paniagua-Zambrana N, Castaneda Sifuentes RY et al (2015) Health in a pot-the ethnobotany of emolientes and emolienteros in Peru. Econ Bot 69:83–88

    Article  Google Scholar 

  • Bussmann RW, Paniagua Zambrana NY, Moya Huanca LA, Hart R (2016) Changing markets—medicinal plants in the markets of La Paz and El Alto, Bolivia. J Ethnopharmacol 193:76–95

    Article  PubMed  Google Scholar 

  • Cabrera AL (1951) Huarpea, nuevo género de Compuestas. Bol Soc Argent Bot 4:129–132

    Google Scholar 

  • Cabrera AL (1959) Revisión del género Dasyphyllum (Compositae). Rev Mus La Plata 9(38):21–100

    Google Scholar 

  • Cabrera AL (1997) Nota crítica en la tribu Mutisieae (Compositae) para la flora de Paraguay. Candollea 52:216

    Google Scholar 

  • Calabria LM, Emerenciano VP, Ferreira MJP et al (2007) A phylogenetic analysis of tribes of the Asteraceae based on phytochemical data. Nat Prod Commun 2:277–285

    CAS  Google Scholar 

  • Calabria LM, Emerenciano VP, Scotti MT, Mabry TJ (2009) Secondary chemistry of compositae. In: Funk V, Susanna A, Stuessy TF, Robinson H (eds) Compositae: systematics, evolution, and biogeography of compositae. International Association for Plant Taxonomy, Vienna

    Google Scholar 

  • Camaqui AM (2007) Plantas medicinales. La experiencia de Tinguipaya. Editorial Gente Común, La Paz

    Google Scholar 

  • Campos-Navarro R, Scarpa GF (2013) The cultural-bound disease “empacho” in Argentina. A comprehensive botanico-historical and ethnopharmacological review. J Ethnopharmacol 148:349–360

    Article  CAS  PubMed  Google Scholar 

  • Carullo G, Cappello AR, Frattaruolo L, Badolato M, Armentano B, Aiello F (2017) Quercetin and derivatives: useful tools in inflammation and pain management. Future Med Chem 9:79–93

    Article  CAS  PubMed  Google Scholar 

  • Casado R, Landa A, Calvo J et al (2011) Anti-inflammatory, antioxidant and antifungal activity of Chuquiraga spinosa. Pharm Biol 49:620–626

    Article  CAS  PubMed  Google Scholar 

  • Castelucci S, de Paula Rogerio A, Ambrosio SR et al (2007) Anti-inflammatory activity of Dasyphyllum brasiliensis (Asteraceae) on acute peritonitis induced by beta-glucan from Histoplasma capsulatum. J Ethnopharmacol 112:192–198

    Article  PubMed  Google Scholar 

  • Ceuterick M, Vandebroek I, Pieroni A (2011) Resilience of Andean urban ethnobotanies: a comparison of medicinal plant use among Bolivian and Peruvian migrants in the United Kingdom and in their countries of origin. J Ethnopharmacol 136:27–54

    Article  PubMed  Google Scholar 

  • Ching-Wen C, Yun-Chieh C, Yu-Chin L, Wen-Huang P (2017) p-Hydroxyacetophenone suppresses nuclear factor-κB-related inflammation in nociceptive and inflammatory animal models. J Med 71(2):422–432

    Google Scholar 

  • Collins J (1870) Notes on some new little-known vegetable products. Pharm J Trans 11:66–67

    Google Scholar 

  • Da Costa FB, Schorr K, Arakawa NS, Schilling EE, Spring Otmar (2001) Infraspecific variation in the chemistry of glandular trichomes of two Brazilian Viguiera species (Heliantheae; Asteraceae). J Braz Chem 12:403–407

    Article  Google Scholar 

  • Da Costa FB, Terfloth L, Gasteiger J (2005) Sesquiterpene-lactone based classification of three Asteraceae tribes: a study based on self-organizing neural networks applied to chemosystematics. Phytochemistry 66:345–353

    Article  CAS  PubMed  Google Scholar 

  • De Feo V (2003) Ethnomedical field study in northern Peruvian Andes with particular reference to divination practices. J Ethnopharmacol 85:243–256

    Article  PubMed  Google Scholar 

  • de Kraker JW, Franssen MC, Dalm MC et al (2001) Biosynthesis of germacrene A carboxylic acid in chicory roots. Demonstration of a cytochrome P450(+)-germacrene a hydroxylase and NADP+-dependent sesquiterpenoid dehydrogenase(s) involved in sesquiterpene lactone biosynthesis. Plant Physiol 125:1930–1940

    Article  PubMed  PubMed Central  Google Scholar 

  • de Kraker JW, Franssen MC, Joerink M et al (2002) Biosynthesis of costunolide, dihydrocostunolide, and leucodin. Demonstration of cytochrome P450-catalyzed formation of the lactone ring present in sesquiterpene lactones of chicory. Plant Physiol 129:257–268

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • de la Torre L, Alarcón DS, Kvist LP, Lecaro JS (2008) Usos medicinales de las plantas. In: de la Torre L, Navarrete H, Muriel PM et al (eds) Enciclopedia de las plantas útiles del Ecuador. Herbario QCA & Herbario AAU, Quito & Aarhus

  • de Mösbach EW (1991) Botánica Indígena de Chile. Editorial Andrés Bello, Santiago de Chile

    Google Scholar 

  • De-la-Cruz H, Vilcapoma G, Zevallos PA (2007) Ethnobotanical study of medicinal plants used by the Andean people of Canta, Lima, Peru. J Ethnopharmacol 111:284–294

    Article  PubMed  Google Scholar 

  • Díaz-Piedrahita S, Vélez-Nauer C (1993) Revisión de las tribus Barnadesieae y Mutisieae (Asteraceae) para la flora de Colombia. Jardín Botánico José Celestino Mutis, Bogotá

    Google Scholar 

  • Duenas AA, Alcivar UE, Olazabal E, Cortes R (2014) Efecto antioxidante de la Chuquiraga jussieui J.F.Gmel en el ensayo de hemólisis. Medicent Electrón 18:57–64

    Google Scholar 

  • Duke JA, Bogenschutz-Godwin MJ, Ottensen AR (2009) Duke’s handbook of medicinal plants of Latin America. CRC Press, Boca Raton

    Google Scholar 

  • Estomba D, Ladio A, Lozada M (2006) Medicinal wild plant knowledge and gathering patterns in a Mapuche community from North-western Patagonia. J Ethnopharmacol 103:109–119

    Article  PubMed  Google Scholar 

  • Ezcurra C (1985) Revisión del género Chuquiraga (Compositae: Mutisieae). Darwiniana 26:219–284

    Google Scholar 

  • Flagg ML, Valcic S, Montenegro G et al (1999) Pentacyclic triterpenes from Chuquiraga ulicina. Phytochemistry 52:1345–1350

    Article  CAS  PubMed  Google Scholar 

  • Funk VA, Roque N (2011) The monotypic Andean genus Fulcaldea (Compositae, Barnadesioideae) gains a new species from northeastern Brazil. Taxon 60:1095–1103

    Google Scholar 

  • Funk VA, Bayer RJ, Keeley S et al (2005) Everywhere but Antarctica: using a super tree to understand the diversity and distribution of the Compositae. Biol Skr 55:343–374

    Google Scholar 

  • Gálvez M, Pastor A (1996) Estudio fitoquímico de la Chuquiraga spinosa. Revista de Química 10:133–134

    Google Scholar 

  • Giberti GC (1983) Herbal folk medicine in northwestern Argentina: Compositae. J Ethnopharmacol 7:321–341

    Article  CAS  PubMed  Google Scholar 

  • Gioti K, Tenta R (2015) Bioactive natural products against prostate cancer: mechanism of action and autophagic/apoptotic molecular pathways. Planta Med 81:543–562

    Article  CAS  PubMed  Google Scholar 

  • Granada A (1997) Una nueva especie de Chuquiraga (Asteraceae, Mutisieae) del Perú. Kurtziana 25:151–156

    Google Scholar 

  • Gruenstaeudl M, Urtubey E, Jansen RK et al (2009) Phylogeny of Barnadesioideae (Asteraceae) inferred from DNA sequence data and morphology. Mol Phylogenet Evol 51:572–587

    Article  CAS  PubMed  Google Scholar 

  • Gupta MP (2006) Medicinal plants originating in the Andean high plateau and central valleys region of Bolivia, Ecuador and Peru. UNIDO report, United Nations

  • Gurovic MS, Castro MJ, Richmond V et al (2010) Triterpenoids with acetylcholinesterase inhibition from Chuquiraga erinacea D. Don. subsp. erinacea (Asteraceae). Planta Med 76:607–610

    Article  CAS  PubMed  Google Scholar 

  • Harling G (1991) Compositae-Mutisieae. In: Harling G, Andersson L (eds) Flora of Ecuador, vol 42. University of Götenborg, Göteborg

    Google Scholar 

  • Herrera FL (1933) Plantarum Cuzcorum Herrerarianum. Estudios sobre la flora del departamento del Cuzco. Sanruarti, Lima

    Google Scholar 

  • Herrera FL (1938) Plantas que curan y plantas que matan de la flora del Cuzco. Revista Universitaria 75:4–76

    Google Scholar 

  • Herrera-Calderon O, Tinco-Jayo JA, Franco-Quino C et al (2017) Antioxidant activity and cytotoxic profile of Chuquiraga spinosa Lessing on human tumor cell lines: a promissory plant from Peruvian flora. Asian Pac J Trop Dis 7:304–308

    Article  Google Scholar 

  • Hind DJN (2001) A new species of Barnadesia (Compositae: Barnadesieae) from Bolivia. Kew Bull 56:705–710

    Article  Google Scholar 

  • Hind N, Hall T (2003) Plate 459. Barnadesia arborea Compositae. Curtis’s Bot Mag 20:25–30

    Article  Google Scholar 

  • Hoeneisen M, Rojas A, Bittner M et al (2000) Constituents of Chuquiraga atacamensis and C. ulicina. Bol Soc Chil Quim 45:49–52

    CAS  Google Scholar 

  • Huamantupa I, Cuba M, Urrunaga R et al (2011) Riqueza, uso y origen de plantas medicinales expendidas en los mercados de la ciudad del Cusco. Rev Peru Biol 18:283–291

    Google Scholar 

  • Jadán MB, Orquera GX, Mihai RA (2014) Establishment of an in vitro culture protocol of Chuquiraga jussieui J.F.Gmel. from apical and axillary buds. Rom Biotechnol Lett 19:9984–9991

    Google Scholar 

  • Jansen RK, Palmer JD (1987) A chloroplast DNA inversion marks an ancient evolutionary split in the sunflower family (Asteraceae). Proc Natl Acad Sci USA 84:5818–5822

    Article  CAS  PubMed  Google Scholar 

  • Juárez BE, Mendiondo ME (2002a) Flavonoides en Chuquiraga acanthophylla Weddell subfamilia Barnadesioideae (Asteraceae). In: I Congreso Latinoamericano de Fitoquímica, IV Reunion de la sociedad Latinoamericana de Fitoquimica, Buenos Aires, 8–10 May 2002

  • Juárez BE, Mendiondo ME (2002b) Flavonoid chemistry of Chuquiraga (Asteraceae). Biochem Syst Ecol 30:371–373

    Article  Google Scholar 

  • Juárez BE, Mendiondo ME (2007) Significado quimiotaxonomico de los flavonoides presentes en Doniophyton anomallum (D. Don) Kurtz (Asteraceae). B Latinoam Caribe PL 6:252–253

    Google Scholar 

  • Katinas L, Stuessy TF (1997) Revision of Doniophyton (Compositae, Barnadesioideae). Plant Syst Evol 206:33–45

    Article  Google Scholar 

  • Kim K-J, Choi K-S, Jansen RK (2005) Two chloroplast DNA inversions originated simultaneously during the early evolution of the sunflower family (Asteraceae). Mol Biol Evol 22:1783–1792

    Article  CAS  PubMed  Google Scholar 

  • Ladio AH, Lozada M (2009) Human ecology, ethnobotany and traditional practices in rural populations inhabiting the Monte region: resilience and ecological knowledge. J Arid Environ 73:222–227

    Article  Google Scholar 

  • Landa A, Casado R, Calvo MI (2009) Identification and quantification of flavonoids from Chuquiraga spinosa (Asteraceae). Nat Prod Commun 4:1353–1355

    CAS  PubMed  Google Scholar 

  • Lundberg J (2009) Asteraceae and relationships within Asterales. In: Funk V, Susanna A, Stuessy TF, Robinson H (eds) Compositae: systematics, evolution, and biogeography of compositae. International Association for Plant Taxonomy, Vienna

    Google Scholar 

  • Macía MJ, García E, Vidaurre PJ (2005) An ethnobotanical survey of medicinal plants commercialized in the markets of La Paz and El Alto, Bolivia. J Ethnopharmacol 97:337–350

    Article  PubMed  Google Scholar 

  • Madaleno IM (2007) Etno-farmacología en Iberoamérica, una alternativa a la globalización de las prácticas de cura. Cuadernos Geográficos 41:61–95

    Google Scholar 

  • Madaleno IM (2012) Organic cultivation and use of medicinal plants in Latin America. Pharmacogn Commn 2:34–51

    Article  CAS  Google Scholar 

  • Martínez CEC (2006) Plantas medicinales de los Andes Ecuatorianos. In: Moraes MR, Øllgaard B, Kvist LP et al (eds) Botánica Económica de los Andes Centrales. Universidad Mayor de San Andrés, La Paz

    Google Scholar 

  • Mendiondo ME, Juárez BE (2001) Flavonoids of Doniophyton patagonicum (Phil.) Hieron. (Asteraceae). Biochem Syst Ecol 29:437–438

    Article  CAS  PubMed  Google Scholar 

  • Mendiondo ME, Juarez BE, Seeligmann P (1997) Flavonoid patterns of some Barnadesioideae (Asteraceae). Eventual chemosystematic significance. Biochem Syst Ecol 25:673–674

    Article  CAS  Google Scholar 

  • Mendiondo ME, Juárez BE, Seeligmann P (2000) Flavonoid profiles of some Argentine species of Chuquiraga (Asteraceae). Biochem Syst Ecol 28:283–285

    Article  CAS  Google Scholar 

  • Mendiondo ME, Juárez BE, Zampini C et al (2011) Bioactivities of Chuquiraga straminea Sandwith. Nat Prod Commun 6:965–968

    CAS  PubMed  Google Scholar 

  • Monigatti M, Bussmann RW, Weckerle CS (2012) Medicinal plant use in two Andean communities located at different altitudes in the Bolívar Province, Peru. J Ethnopharmacol 145:450–464

    Article  PubMed  Google Scholar 

  • Mostacero J, Castillo F, Mejia FR et al (2011) Plantas medicinales del Perú. Taxonomía, ecogeografía, fenología y etnobotánica. Asamblea Nacional de Rectores, Lima

    Google Scholar 

  • Nguyen DT, Göpfert JC, Ikezawa N et al (2010) Biochemical conservation and evolution of germacrene A oxidase in Asteraceae. J Biol Chem 285:16588–16598

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Nguyen TD, Faraldos JA, Vardakou M et al (2016) Discovery of germacrene A synthases in Barnadesia spinosa: the first committed step in sesquiterpene lactone biosynthesis in the basal member of the Asteraceae. Biochem Biophys Res Commun 479:622–627

    Article  CAS  PubMed  Google Scholar 

  • Padilla-Gonzalez GF, dos Santos FA, Da Costa FB (2016) Sesquiterpene lactones: more than protective plant compounds with high toxicity. Crit Rev Plant Sci 35:18–37

    Article  CAS  Google Scholar 

  • Panero JL, Funk VA (2008) The value of sampling anomalous taxa in phylogenetic studies: major clades of the Asteraceae revealed. Mol Phylogenet Evol 47:757–782

    Article  CAS  PubMed  Google Scholar 

  • Passoni FD, Carollo C, Gobbo-Neto L et al (2008) Polifenóis na fração ativa de espinho-agulha (Dasyphyllum brasiliense, Asteraceae), uma planta medicinal com atividade antiinflamatória. In: 31a Reunião Anual da Sociedade Brasileira de Química, Águas de Lindóia, 26–29 May 2008

  • Paula CS, Verdam MCS, Souza AM et al (2013) Prospecção fitoquímica e avaliação preliminar da atividade antibacteriana dos extratos das folhas e casca do caule de Dasyphyllum tomentosum (Spreng.) Cabrera. Visão Acadêmica 14:4–12

    Google Scholar 

  • Pietta PG (2000) Flavonoids as antioxidants. J Nat Prod 63:1035–1042

    Article  CAS  PubMed  Google Scholar 

  • Quattrocchi U (2012) CRC world dictionary of plant names: common names, scientific names, eponyms, synonyms, and etymology. CRC Press, New York

    Google Scholar 

  • Raad K (2012) Medicina ancestral de los Amaychas. Amagrafik, Tucuman

    Google Scholar 

  • Ramírez C, Beloso C (2002) Usos tradicionales de las plantas en la Meseta Patagónica. Jardín Botánico de la Patagonia Extraandina. CENPAT-CONICET-ICBG. Dirección de Impresiones Oficiales, Chubut

  • Rehecho S, Uriarte-Pueyo I, Calvo J et al (2011) Ethnopharmacological survey of medicinal plants in Nor-Yauyos, a part of the landscape reserve Nor-Yauyos-Cochas, Peru. J Ethnopharmacol 133:75–85

    Article  PubMed  Google Scholar 

  • Ribeiro D, Freitas M, Tomé SM, Silva AM, Laufer S, Lima JL, Fernandes E (2015) Flavonoids inhibit COX-1 and COX-2 enzymes and cytokine/chemokine production in human whole blood. Inflammation 38:858–870

    Article  CAS  PubMed  Google Scholar 

  • Richeri M, Ladio AH, Beeskow AM (2013) Conocimiento tradicional y autosuficiencia: la herbolaria rural en la meseta central del Chubut (Argentina). B Latinoam Caribe PL 12:44–58

    Google Scholar 

  • Roersch C (1994) Plantas medicinales en el sur andino del Peru. Koeltz Scientific Books, Koenigstein

    Google Scholar 

  • Rondina RVD, Bandoni AL, Coussio JD (2008) Especies medicinales argentinas con potencial actividad analgésica. Dominguezia 24:47–69

    Google Scholar 

  • Saavedra MM, Monge M, Guimarães EF (2014) Dasyphyllum diamantinense (Asteraceae, Barnadesioideae): a new species from the Chapada Diamantina, Bahia State, Brazil. Phytotaxa 174:231–236

    Article  Google Scholar 

  • Sagástegui AA (1980) Compuestas andino-peruanas nuevas para la ciencia. Bol Soc Argent Bot 19:61–68

    Google Scholar 

  • Sagástegui AA, Dillon MO (1985) Four new species of Asteraceae from Peru. Brittonia 37:6–13

    Article  Google Scholar 

  • Sagástegui AA, Sánchez VL (1991) Una nueva especie de Chuquiraga (Asteraceae, Mutisieae) del norte del Perú. Arnaldoa 1:1–4

    Google Scholar 

  • Sala A, Recio MC, Giner RM, Máñez S, Ríos JL (2001) New acetophenone glucosides isolated from extracts of Helichrysum italicum with antiinflammatory activity. J Nat Prod 64:1360–1362

    Article  CAS  PubMed  Google Scholar 

  • Seamann FC (1982) Sesquiterpene lactones as taxonomic characters in the Asteraceae. Bot Rev 48:121–594

    Article  Google Scholar 

  • Senatore F (1996) Composition of the essential oil of Chuquiraga spinosa (R. et P.) D. Don. Flav Frag J 11:215–217

    Article  CAS  Google Scholar 

  • Senatore F, Nunziata A, D’Agostino M, de Feo V (1999) Flavonol glycosides and p-hydroxyacetophenone from Chuquiraga spinosa. Pharm Biol 37:366–368

    Article  CAS  Google Scholar 

  • Shahidi F, Chandrasekara A (2010) Hydroxycinnamates and their in vitro and in vivo antioxidant activities. Phytochem Rev 9:147–170

    Article  CAS  Google Scholar 

  • Siura SC, Flores MP (2010) Etnobotánica de las plantas medicinales de las comunidades campesinas de Quero y Masma Chicche. In: Gallo MP, Galarza VG, Gabriel JM, Moris G (eds) Las plantas medicinales del Perú: etnobotánica y viabilidad comercial. Los libros de la Catarata, Madrid

    Google Scholar 

  • Soubeiran L (1868) Extrait du proces-verbal de la séance de la Société de pharmaie de Paris. Journal de Pharmacie et de Chimie 4(8):303

    Google Scholar 

  • Spring O (1989) Microsampling: an alternative approach using sesquiterpene lactones for systematics. Biochem Syst Ecol 17:509–517

    Article  CAS  Google Scholar 

  • Spring O (2000) Chemotaxonomy based on metabolites from glandular trichomes. In: Hallahan DL, Gray JC (ed) Plant trichomes, advances in botanical research, vol 31. Academic Press, London, pp 153–174

    Google Scholar 

  • Stuessy TF, Sagástegui AA (1993) Revisión de Arnaldoa (Compositae, Barnadesioideae), género endémico del Norte del Perú. Arnaldoa 1:9–21

    Google Scholar 

  • Stuessy TF, Urtubey E, Gruenstaeudl M (2009) Barnadesieae (Barnadesioideae). In: Funk V, Susanna A, Stuessy TF, Robinson H (eds) Compositae: systematics, evolution, and biogeography of compositae. International Association for Plant Taxonomy, Vienna

    Google Scholar 

  • Tene V, Malagón O, Finzi PV et al (2007) An ethnobotanical survey of medicinal plants used in Loja and Zamora-Chinchipe, Ecuador. J Ethnopharmacol 111:63–81

    Article  PubMed  Google Scholar 

  • Torres H, Borel R, Bustamante N, Centeno MI (1992) Usos tradicionales de arbustos nativos en el sur de Puno. Publifor, Puno

    Google Scholar 

  • Ulloa Ulloa C, Jørgensen PM, Dillon MO (2002) Arnaldoa argentea (Barnadesioideae: Asteraceae) a new species and a new generic record for Ecuador. Novon 12:415–419

    Article  Google Scholar 

  • Urtubey E (1999) Revisión del género Barnadesia (Asteraceae: Barnadesioideae, Barnadesieae). Ann Mo Bot Gard 86:57–117

    Article  Google Scholar 

  • Vandebroek I, Thomas E, AMETRAC (2003) Plantas medicinales para la atención primaria de la salud. El conocimiento de ocho médicos tradicionales de Apillapampa (Bolivia). Industrias Graficas Serrano, Cochabamba

    Google Scholar 

  • Vásquez LN, Escurra JP, Aguirre RT et al (2010) Plantas medicinales del Norte del Perú. Universidad Nacional Pedro Ruiz Gallo, Lambayeque

    Google Scholar 

  • Villagrán C, Castro V, Sánchez G et al (1998) La tradición surandina del desierto: Etnobotánica del área del Salar de Atacama (Provincia de El Loa, Región de Antofagasta, Chile). Estudios Atacameños 16:7–105

    Google Scholar 

  • Villagrán C, Romo M, Castro V (2003) Etnobotánica del sur de los Andes de la primera región de Chile: un enlace entre las culturas altiplánicas y las de quebradas altas del Loa Superior. Chungara 35:73–124

    Google Scholar 

  • Yakovleff E, Herrera FH (1934) El mundo vegetal de los antiguos Peruanos. Rev Mus Nac/Lima 3:240–322

    Google Scholar 

  • Yang F, Song L, Wang H, Wang J, Xu Z, Xing N (2015) Quercetin in prostate cancer: chemotherapeutic and chemopreventive effects, mechanisms and clinical application potential. Oncol Rep 33:2659–2668

    Article  CAS  PubMed  Google Scholar 

  • Zamora VHC (2008) Estudio de aproximaciones etnobotánicas en áreas productoras del intersalar de Quinua Real del departamento de Potosi (Parte I). Fundacion Alitapo, Potosi

    Google Scholar 

  • Zampini IC, Cudmani N, Isla MI (2007) Actividad antimicrobiana de plantas medicinales argentinas sobre bacterias antibiótico-resistentes. Acta Bioquim Clin L 41:385–393

    Google Scholar 

  • Zampini IC, Cuello S, Alberto MR et al (2009) Antimicrobial activity of selected plant species from “the Argentine Puna” against sensitive and multi-resistant bacteria. J Ethnopharmacol 124:499–505

    Article  CAS  PubMed  Google Scholar 

  • Zampini IC, Ordoñez RM, Isla MI (2010) Autographic assay for the rapid detection of antioxidant capacity of liquid and semi-solid pharmaceutical formulations using ABTS∙+ immobilized by gel entrapment. AAPS PharmSciTech 11:1159–1163

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zardini EM, Soria N (1994) A new species of Dasyphyllum (Asteraceae–Mutisieae) from Paraguay. Novon 4:80–82

    Article  Google Scholar 

  • Zdero C, Bohlmann F (1990) Systematics and evolution within the Compositae, seen with the eyes of a chemist. Plant Syst Evol 171:1–14

    Article  Google Scholar 

  • Zdero C, Bohlmann F, King RM, Robinson H (1986a) Further 5-methyl coumarins and other constituents from the subtribe mutisiinae. Phytochemistry 25:509–516

    Article  CAS  Google Scholar 

  • Zdero C, Bohlmann F, King RM, Robinson H (1986b) α-Isocedrene derivatives, 5-methyl coumarins and other constituents from the subtribe Nassauviinae of the Compositae. Phytochemistry 25:2873–2882

    Article  CAS  Google Scholar 

  • Zdero C, Bohlmann F, King RM (1987) Chemistry of the Barnadesiinae (Asteraceae). Phytologia 63:313–315

    Google Scholar 

Download references

Acknowledgements

The authors acknowledge the Brazilian research funding agencies Foundation for the Coordination and Improvement of Higher Level or Education Personnel (CAPES), National Council for Scientific and Technological Development (CNPq), and São Paulo Research Foundation (FAPESP, Grants #2014/16850-6 and #2014/26866-7) for fellowship and funding. Mr. G.F. Padilla-González (FCFRP-USP) is acknowledged for his comments on the manuscript. We thank Dr. G. Shimizu (Inst. Biology, UNICAMP) and Dr. G. Heiden (EMBRAPA Temperate Agriculture) for providing pictures of Barnadesioideae. We also acknowledge Prof. Dr. M. Groppo Jr. (Dept. Biology, FFCLRP-USP) and Prof. Dr. J. Semir (Inst. Biology, UNICAMP) for their valuable support and discussions.

Author information

Authors and Affiliations

  1. AsterBioChem Research Team, Laboratory of Pharmacognosy, School of Pharmaceutical Sciences of Ribeirão Preto (FCFRP), University of São Paulo (USP), Av. do Café s/n, Ribeirão Prêto, SP, 14040-903, Brazil

    Gari V. Ccana-Ccapatinta & Fernando B. Da Costa

  2. Graduate Program of Plant Biology, Institute of Biology, University of Campinas (UNICAMP), R. Monteiro Lobato 255, Campinas, SP, 13083-862, Brazil

    Marcelo Monge

  3. Laboratory of Plant Systematics, Department of Biology, Faculty of Philosophy, Sciences and Letters at Ribeirão Preto (FFCLRP), USP, Av. dos Bandeirantes 3900, Ribeirão Prêto, SP, 14040-901, Brazil

    Paola L. Ferreira

Authors
  1. Gari V. Ccana-Ccapatinta
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Marcelo Monge
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Paola L. Ferreira
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Fernando B. Da Costa
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Fernando B. Da Costa.

Electronic supplementary material

Below is the link to the electronic supplementary material.

Supplementary material 1 (DOCX 257 kb)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Ccana-Ccapatinta, G.V., Monge, M., Ferreira, P.L. et al. Chemistry and medicinal uses of the subfamily Barnadesioideae (Asteraceae). Phytochem Rev 17, 471–489 (2018). https://doi.org/10.1007/s11101-017-9544-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11101-017-9544-y

Keywords

Search

Navigation