Current status of CPT and its analogues in the treatment of malignancies
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Camptothecin (CPT) is a kind of terpene indole alkaloid which was firstly isolated from native Chinese happy tree Camptotheca acuminata and owns a unique anti-tumor mechanism by inhibiting Topo I. Being approved by FDA, the camptothecin derivatives, irinotecan and topotecan, are extensively used for the treatment of various cancers throughout the world. In the past decades, pharmacology of CPT and its analogues has been well documented. This review will focus on different human malignancies with demonstrated clinical efficacy of CPT analogues.
KeywordsAnalogues Camptothecin Chemotherapy Malignancies
The authors are grateful for financial sponsored by the Shanghai Committee of Science and Technology, China (13140902402).
Conflict of interest
The authors confirm that this article content has no conflicts of interest.
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