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Natural products and their derivatives as inhibitors of glycogen phosphorylase: potential treatment for type 2 diabetes

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Abstract

Glycogen phosphorylase (GP) (EC 2.4.1.1) is an important therapeutic target for the potential treatment of type 2 diabetes. The search for potent, selective and drug-like GP inhibitors which may eventually lead to hypoglycaemic agents has to date uncovered a number of natural product inhibitors with both pharmaceutical and nutraceutical potential. GP is an allosteric protein with at least six different ligand binding sites that modulate its enzymatic activity. Hence, inhibitors with considerable structural diversity can be designed. This review is focused on advances in the discovery of natural products and their derivatives as GP inhibitors.

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Acknowledgments

A.L.K. and D.D.L. would like to acknowledge the support of the “ARISTEIA” Action of the “Operational Programme Education and Lifelong Learning” co-funded by the European Social Fund (ESF) and National Resources. This work was also supported in part by the Postgraduate Programmes ‘‘Biotechnology-Quality assessment in Nutrition and the Environment”, ‘‘Application of Molecular Biology-Molecular Genetics-Molecular Markers”, Department of Biochemistry and Biotechnology, University of Thessaly.

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  1. Division of Chemistry, Centre for Materials Science, University of Central Lancashire, Preston, PR1 2HE, UK

    Joseph M. Hayes

  2. Department of Biochemistry and Biotechnology, University of Thessaly, 26 Ploutonos Str., 41221, Larissa, Greece

    Anastassia L. Kantsadi & Demetres D. Leonidas

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  1. Joseph M. Hayes
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  2. Anastassia L. Kantsadi
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  3. Demetres D. Leonidas
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Hayes, J.M., Kantsadi, A.L. & Leonidas, D.D. Natural products and their derivatives as inhibitors of glycogen phosphorylase: potential treatment for type 2 diabetes. Phytochem Rev 13, 471–498 (2014). https://doi.org/10.1007/s11101-014-9360-6

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