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Phytochemistry Reviews

, Volume 13, Issue 4, pp 915–935 | Cite as

Euphorbia and Momordica metabolites for overcoming multidrug resistance

  • Maria-José U. Ferreira
  • Noélia Duarte
  • Mariana Reis
  • Ana Margarida Madureira
  • Joseph Molnár
Article

Abstract

Multidrug resistance (MDR) is the major obstacle for cancer chemotherapy. MDR is a multifactorial phenomenon that can result from several mechanisms, including an increased drug efflux, due to overexpression of P-glycoprotein (P-gp) that transports anticancer drugs out of the cells. Thus, the role of this transporter has made it a therapeutic target and the development of P-gp modulators considered among the most realistic approaches for overcoming P-gp-mediated MDR. Many other strategies have been proposed. One of them is the identification of compounds that selectively kill multidrug resistant cells. In our search for MDR modulators from plants, the P-gp inhibition ability of a large number of compounds on resistant cancer cells was evaluated. These compounds, presented in this review, comprise mainly diterpenes, triterpenes and phenolic derivatives. The most relevant results were obtained from two sets of compounds: macrocyclic diterpenes with the jatrophane and lathyrane scaffold, and triterpenes of the cucurbitane-type isolated from Euphorbia species and Momordica balsamina L., respectively. Additionally, some of those macrocyclic diterpenes, and ent-abietane diterpenic lactones, also isolated from Euphorbia species, were found to be selectively toxic to drug-resistant phenotypes.

Keywords

Euphorbia ent-Abietane lactones Macrocyclic diterpenes Momordica balsamina L. P-glycoprotein Triterpenes 

Notes

Acknowledgments

This study was financially supported by Fundação para a Ciência e a Tecnologia (FCT), Portugal (Projects: PTDC/QUI-QUI/099815/2008; PEst-OE/SAU/UI4013/2011; PTDC/QEQ-MED/0905/2012. Ph.D. Grant SFRH/BD/72915/2010).

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Copyright information

© Springer Science+Business Media Dordrecht 2014

Authors and Affiliations

  • Maria-José U. Ferreira
    • 1
  • Noélia Duarte
    • 1
  • Mariana Reis
    • 1
  • Ana Margarida Madureira
    • 1
  • Joseph Molnár
    • 2
  1. 1.Faculty of Pharmacy, Instituto de Investigação do Medicamento (iMed.ULisboa)University of LisbonLisbonPortugal
  2. 2.Department of Medical MicrobiologyUniversity of SzegedSzegedHungary

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