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Phytochemistry Reviews

, Volume 13, Issue 1, pp 51–68 | Cite as

Antitumour activities of sanguinarine and related alkaloids

  • Iva Slaninová
  • Kristýna Pěnčíková
  • Jana Urbanová
  • Jiří Slanina
  • Eva Táborská
Article

Abstract

Sanguinarine is a best-known member of a relatively small group of quaternary benzo[c]phenanthridine alkaloids (QBAs). QBAs are widely distributed in the family Papaveraceae and, to a limited extent, in some species of the families Fumariaceae and Rutaceae. From a medical perspective, QBAs have many important properties. In addition to antitumour activity, they display antimicrobial, antifungal and anti-inflammatory effects. They may interact with many targets, such as DNA and microtubules, and they modify the activities of a wide variety of enzymes. This review summarises the current state of knowledge about the properties of QBAs that are important for their potential use in anticancer therapy.

Keywords

Apoptosis Anti-proliferative activity Benzophenanthridine alkaloids Cancer Sanguinarine 

Abbreviations

Bcl2

B-cell lymphoma 2 protein

DHSA

Dihydrosanguinarine

CHE

Chelerythrine

CHL

Chelilutine

CHLD

Chelidonine

CHR

Chelirubine

MA

Macarpine

MAPK

Mitogen-activated protein kinase

MT

Microtubule

NAC

N-acetylcysteine

NK109

7-Hydroxy-8-methoxy-5-methyl-2,3methylenedioxybenzo[c]phenanthridinium hydrogen sulfate

NK314

4-Hydroxy-5-methoxy-2,3-dihydro-1H-[1,3]benzodioxolo[5,6-c]pyrrolo[1,2-f]-phenanthridinium chloride

QBAs

Quaternary benzo[c]phenanthridine alkaloids

ROS

Reactive oxygen species

SA

Sanguinarine

SL

Sanguilutine

SR

Sanguirubine

TRAIL

Tumour necrosis factor-related apoptosis-inducing ligand

CDK

Cyclin-dependent kinase

DHF-DA

Dihydrofluorescein diacetate

DR4 5

Death receptor 4 and 5

γH2AX

Phosphorylated histone H2AX

IAP

Inhibitor of apoptosis

MMP-2 MMP-9

Matrix metalloproteinase-2 and 9

RIP

Receptor-interacting protein

VEGF

Vascular endothelial growth factor

Notes

Acknowledgments

The work was supported by grants of Ministry of Education, Youth and Sports of the Czech Republic (KONTAKT II LH12176) and Masaryk University Projects of Specific Research MUNI/A/0798/2012 and MUNI/A/0818/2012.

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Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  • Iva Slaninová
    • 1
  • Kristýna Pěnčíková
    • 2
  • Jana Urbanová
    • 2
  • Jiří Slanina
    • 2
  • Eva Táborská
    • 2
  1. 1.Department of Biology, Faculty of MedicineMasaryk UniversityBrnoCzech Republic
  2. 2.Department of Biochemistry, Faculty of MedicineMasaryk UniversityBrnoCzech Republic

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