Abstract
Numerous researches have been carried out in Zingiber zerumbet Smith. Since 1944 till date. Z. zerumbet is a monocotyledonous perennial medicinal plant belonging to Zingiberaceae family. It is commonly known as shampoo ginger. It has many different local names depending on their area of collection and vegetation. It is called as ‘Singkha’ in Manipuri. Various compounds have been reported to be isolated from Z. zerumbet and they serve a very potent and reliable drug candidate for the various diseases. They have been investigated for its prospects of effectiveness against number of activities in in vitro as well as in vivo and mechanisms that may be involved in chemo preventive measures and various pharmaceutical studies.
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Abdel Wahab SI, Bustamam A, Abdul, Alzubairi AS, Elhassan MM, Mohan S (2009) In vitro ultramorphological assessment of apoptosis induced by Zerumbone on (HeLa). J Biomed Biotechnol ArticleID 769568, 10 pp. doi:10.1155/2009/769568
Abdul AB, Adel SA, Nirmala DT, Siddig SI, Zetty ZN, Sharin R et al (2008) Anticancer activity natural compound (zerumbone) extracted from Zingiber zerumbet in human HeLa cervical cancer cells. Int J Pharmacol 4:160–168
Ahmad UK, Irat HM, Sanagi MM, Smith RM (1994) J Microcolumn 6:27–32
Al-Saffar FJ, Ganabadi S, Fakurazi S, Yaakub H, Lip M (2010) Chondroprotective effect zerumboneiodo acetate induced osteoarthritis in rats. J Appl Sci 10(4):248–260
Al-zubairi AS, Abdul AB, Siddig IA, Somchit MN (2007) Genetoxicity of zerumbone in peripheral blood lymphocytes evaluated by cytotoxic test. In: Proceedings of 6th international traditional/complementary medicine conference (INTRACOM’07), PWTC, KualaLumpur, Malaysia
Aswati Nair R, Kiran AG, Sivakumar KC, Thomas G (2010) Molecular characterization of an oomycete-responsive PR-5 protein gene from Zingiber zerumbet. Plant Mol Biol Rep 28:128–135
Bensch S, Akesson M (2005) Ten years of AFLP in ecology and evolution: why so few animals? Mol Ecol 14:2899–2914
Bokyung S, Sonia J, Kwang SA, Yoichi M, Tingfang Y, Sushovan G, Mingyao L, Bhara BB (2008) Zerumbone down-regulates chemokine receptor CXCR4 expression leading to inhibition of CXCL12-induced invasion of breast and pancreatic tumor cells. Cancer Res 68:21
Bordia A, Verma SK, Srivastava KC (1997) Effect of ginger (Zingiber officinale Rosc) and fenugreek (Trigomella foenumgraecum L.) on blood lipids, blood sugar and platelet aggregation in patients with coronary artery disease. Prostaglandins Leukot Essent Fatty Acids 56:379–384
Bustamam A, Siddig I, Al-Zubairi AS, Manal MET, Syam MM (2008) Zerumbone: a natural compound with anti-cholinesterase activity. Am J Pharmacol Toxicol 3(3):209–211
Chane-Ming J, Robert V, Chalchat JC (2003) Chemical composition of the essential oil from rhizomes, leaves and flowers of Zingiber zerumbet Smith from Reunion Island. J Essent Oil Res15(3):202–205
Chaungab HC, Chi-Tang H, Tzou-Chi H (2008) Anti-hypersensitive and anti-inflammatory activities of water extract of Zingiber zerumbet (L.). Food Agric Immunol 19(2):117–129
Chen I, Chang Ch, Ng CC, Wang CY, Shyu YT, Chang TL (2008) Antioxidant and antimicrobial activity of Zingiberaceae plants in Taiwan. Plant Foods Hum Nutr 63:15–20
Chiou LC, Ling JY, Chang CC (1997) Chinnese herb constituent beta-eudesmol alleviated the electroshock seizures in mice and electrographic seizures in rat hippocampal slices. Neurosci Lett 15:171–174
Christine S (2007) Clonal propagation of Curcuma zedoaria rocs and Zingiber zerumbet. Ph D thesis, University Sains Malaysia
Chung SY, Jang DS, Han AR, Jang JO, Youngjoo K, Lee HJ, Seo EK (2007) Modulation of P-glycoprotein-mediated resistance by kaemferol derivatives isolated from Zingiber zerumbet. Phytother Res 21:565
Dai JR, Cardellina JH, McMohan JB, Boyd MR (1997) Zerumbone, an HIV-inhibiotory cytotoxic sesquiterpene of Zingiber aromaticum and Zingiber zerumbet. Nat Prod Lett 10:115–118
Dambisiya YM, Lee LT (1995) Effects L-NG-nitro arginine methyl ester (L-NAME), L-NG monomethyl arginine (L-NMMA) and L_arginione on the antinociceptive effects of morphine in mice. Exp Clin Pharmacol 17:577–582
Damodaran NP, Dev S (1965) Attractive reactivity of a Natural product, zerumbone. Tetrahedr Lett 6:1977–1981
Damodaran NP, Dev S (1968a) Studies in sesquiterpenes—XXXVII: sesquiterpenoids from the essential oil of Zingiber zerumbet smith. Tetrahedr Lett 24:4113–4122
Damodaran NP, Dev S (1968b) Studies in sesquiterpenes—XXXVIII: structure of humuleneepoxide-I and humulene epoxide-II. Tetrahedr Lett 24:4123–4132
Damodaran NP, Dev S (1968c) Studies in sesquiterpenes—XXXIX: structure of humulenols. Tetrahedr Lett 24:4133–4142
Dev S (2006) Prime ayurvedic plant drugs, ancient–modern concordance. Anamaya Publisher, New Delhi, pp 459–462
Dung NX, Chinh TD, Rang DD, Leclercq PA (1993) Chemical Investigation of the leaf and rhizomes essential oil. J Essent Oil Res 5:55–59
Duve RN (1980) Highlights of the chemistry and pharmacology of wild ginger (Zingiber zerumbet Smith) Fiji Agric J 42:41–43
Eguchi A, Kaneko Y, Murakami A, Ohigashi H (2007) Zerumbone suppresses phorbol ester-induced expression of multiple scavenger receptor genes in THP-1 human monocytic cells. Biosci Biotechnol Biochem 71:935–945
Elliot S, Brimacombe J (1987) The medicinal plants of Gunung Leusar National Park, Indonesia. J Ethnopharmacol 19:285–317
Farnsworth NR, Bunyapraphatsara N (1992) Thai medicinal plants. Prachachou, Bangkok, pp 261–263
Fengnian Y, Harada H, Kazuhisa Y, Okamotoa Sh, Hirasec S, Tanaka Y, Norihiko M, Utsumia R (2008a) Isolation and functional characterization of a ß-eudesmol synthase, a new sesquiterpene synthase from Zingiber zerumbet. FEBS 582(5):565–572
Fengnian Y, Okamoto S, Nakasore K, Adachi K, Matsuda S, Harada H, Misawa N, Utumi R (2008b) Molecular cloning and functional characterization of α-humulenesynthase, a possible key enzyme on zerumbone biosynthesis in shampoo ginger Zingiber zerumbet Smith. Planta 227:1291–1299
Fengnian Y, Okamoto Sh, Harada H, Kazuhisa Y, Norihiko M, Utsumi R (2010) Zingiber zerumbet CYP71BA1 catalyzes the conversion of a-humulene to 8-hydroxy-a-humulene in zerumbone biosynthesis. Cell Mol Life Sci 68:1033–1040
Fukuoka K, Akiyoshi S, Takeo S, Motoki K, Hiroshi O, Kitayama T, Mutunori S, Koichiro K, Sadao K, Matsuda K (2004) Inhibitory actions of several natural products on proliferation of rat vascular smooth muscle cells induced by Hsp60 from Chlamydia pneumoniae. Agric Food Chem 52:6326–6329
Hamid D, Ali AM, Rajab NF, Alitheen N, Sirat H, and Bakar AA (2007) Zerumbone causes morphological changes on different types of leukemic cell lines. In: Proceeding of the 24th annual conference of the microscopy society of Thailand, Kasetsart University, Bangkok, Thailand
Han AR, Kim MS, Jeong YH, Lee SK, Seo EK (2005) Cyclo-oxygenase-2-inhibitory phenylbutanoids from the rhizomes of Zingiber cassumunar. Chem Phar Bull 53:1466–1468
Harada H, Yu F, Okamoto S, Kuzuyama T, Utsumi R, Misawa N (2009) Efficient synthesis of functional isoprenoids from acetoacetate through metabolic pathway-engineered Escherichia coli. Appl Microbiol Biotechnol 81:915–925
Havrilesky LJ, Elbendary A, Hurteau JA, Whittaker RS, Rodriques GC et al (1995) Chemotherapy induced apoptosis in epithelial ovarian cancers. Obst Gynaecol 85:1007–1010
Helen MPA, Nizzy AM, Jegatheesh TR (2009) Phytochemical characterization and antimicrobial activity of shampoo ginger (Zingiber zerumbet) from Tamil Nadu. India Asian J Microbiol Biotechnol Environ Sci 11(3):625–628
Hoffman AL, Spetner M, Burke M (2002) Redox-regulated mechanism may account for zerumbone’s ability to suppress cancer-cell proliferation. Carcinogenesis 23:1961
Hongliang J, Solyomo MA, Timmermann BN, Gang DR (2005) Metabolic profiling and phylogenetic analysis of medicinal Zingiber zerumbet. Rapid Commun Mass Spectrom 19:2957–2964
Hossain ME, Bhattacharjee SC, Islam MDE nayetul. (2005) Chemical investigation on Zingiber zerumbet. Frontiers in Natural Product Chemistry (1):185–187
Huang GC, Chien TY, Chen LG, Wang CC (2005a) Antitrumour effects of zerumbone from Zingiber zerumbet in P-388D cells in vitro and in vivo. Plant Med 71:219–224
Huang G-C, Chien T-Y, Chen L-g, Wang C–C (2005b) Anti-tumour effects of zerumbone from Zingiber zerumbet in P-388D 1 cells in vitro and in vivo. Planta Med 71:219–224
Hunskaar S, Hole K (1987) Preliminary analysis of the antinociceptive activity of Zerumbone. Pain 30:103
Ibrahim MY, Abdul AB, Abdel W, Elhassan SI, Alzubairi MN, Syam AS, Elhassan MM (2009) Attenuation of cisplatin induced hepatotoxicity in rats using Zerumbone. Res J Biol Sci 4(7):777–784
Idris FD, Jali M, Ibrahim H, Khalid N (2009) Establishment of embryogenic cell suspension and field evaluation of regenerants of Zingiber zerumbet Smith. Acta Horticulturae 829:p 6
Jang DS, Seo EK (2005) Potentially bioactive two new natural sesquiterpenoids from the rhizomes of Zingiber zerumbet. Arch Pharm Res 28(3):294–296
Jang DS, Han AR, Park G, Jhon GJ, Seo EK (2004) Flavanoids and aromatic compounds from the rhizomes of Zingiber zerumbet. Arch Pharm Res 27:386–389
Jang DS, Min HY, Kim MS, Han AR, Windono T, Jeohn GH, Kang SS, Lee SK, Seo EK (2005) Humulene derivatives from Zingiber Zerumbet with the inhibitory effects on lipopolysaccharides-induced nitric oxide production. Chem Pharm Bull 53(7):829–831
Jantan I, Rafi IAA, Alil J (2005) Platelet activating factor (PAF) receptor binding antagonist activity of Malaysian medicinal plants. Phyto Med 27:799–812
Kader MG, Habib MR, Nikkon F, Yeasmin T, Rahid MA, Rahman MM, Gibbons S (2010) Zederone from the rhizomes of Zingier zerumbet and its anti-staphylococcal activity. Boletinlatino Americanoy del caribe de plantas Medicinales y aromaticas 9(1):63–68
Keong YS, Noorjahan BA, Mustafa Sh, Suraini AA, Rahman MA, Abdul MA (2010) Immunomodulatory effects of zerumbone isolated from roots of Zingiber zerumbet. Pak J Pharm Sci 23(1):75–82
Kimura I (2005) Antiangiogenic activity of β eudesmol in vitro and in vivo. Eur J Pharmacol 512:105–115
Kiat TS, Richard P (2006) Screening of selected Zingiberaceae extracts for Dengue-2 virus protease inhibitory activities. Sun Acad J 3:1–7
Kinghorn AD, Fransworth NR, Soejarto DD, Cordell GA, Pezzuto JM, Udeani GO, Wani MC, Wall ME, Navarro HA, Kramer RA, Menendez AT, Fairchild CR, Lane KE, Forenza S, Vyas DM, Lams KS, Shu YZ (1997) Novel strategies for the discovery of plant-derived anticancer agents. Pure Appl Chem 71(9):1611–1618
Kirana C, McIntosh GH, Record IR, Jones GP (2003) Antitumour activity of extracts of Zingiber aromaticum and its bioactive sesquiterpenoid zerumbone. Nutr Cancer 45:218–225
Kitayama T, Okamoto T, Hill RK, Kawai Y, Takahashi S, Yonemori S, Yamamoto Y, Ohe K, Uemura S, Sawada S (1999) Chemistry of Zerumbone Simplified isolation, conjugate addition reactions, and a unique ring contracting transannular reaction of its dibromide. J Org Chem 64:2667–2672
Kitayama T, Yamamoto K, Utsumi K, Takatani M, Hill RK, Kawai Y, Sawada O (2001) Chemistry of zerumbone, regulation of ring bond cleavage and unique antibacterial activities of zerumbone derivatives. Biosci Biotechnol Biochem 65:2193–2199
Koshimizu H, Araki T, Takai S, Yokomaku D, Ishikawa Y, Kubota M, Sano S, Hatanaka H, Yamada M (2002) Expression of CD47/integrin-associated protein induces death of cultured cerebral cortical neurons. J Neurochem 82:249–257
Koshimizu K, Ohigashi H, Tokuda H, Kondo A, Yamaguchi K (1988) Screening of edible plants against anti-tumour promoting activity. Cancer Lett 39:24757
Langner E, Greifenberg S, Gruenwald J (1988) Ginger: history and use. Adv Ther 15:25–44
Lechat-Vahirua I, Francois P, Menut C, Lamaty G, Bessiere JM (1993) Immunomodulatory effects of Zerumbone isolated. J Essent Oil Res 5:55–59
Malek SNA, Ibrahim H, Lai HS, Sem LG, Seng CK, Yusoff MM, Ali NAM (2005) Efficient in vitro regeneration of Zingiber Zerumbet. Smith Malays J Sci 24:49–58
Masuda T, Akiko J, Shigeru K, Nobuji N (1991) Acetylated flavonol glycosides from Zingiber zerumbet. Phytochemistry 30(7):2391–2392
Murakami A, Takahashi M, Jiwajinda S, Koshimizu K, Ohigashi H (1999) Identification of Zerumbone in Zingiber zerumbet Smith as a potent inhibitor of 12-O-tetradecanoylphorbol-13-acetate-induced Epstein-Barr virus activation. Biosci Biotechnol Biochem 63(10):1811–1812
Murakami A, Takahashi D, Kinoshita T et al (2002) Zerumbone, a Southeast Asian ginger sesquiterpene, markedly suppresses free radical generation, proinflammatory protein production, and cancer cell proliferation accompanied by apoptosis: the α, β-unsaturated carbonyl group is a prerequisite. Carcinogenesis 23:795–802
Murakami A, Hayashi R, Tanaka T, Kwon KH, Ohigashi H, Safitri R (2003) Suppression of dextran sodium sulfate-induced colitis in mice by zerumbone, a subtropical ginger sesquiterpene, and nimesulide: separately and in combination. Biochem Pharmacol 66:1253–1261
Murakami A, Tanaka T, Lee JY, Surh YJ, Kim HW, Kawabata K, Nakamura Y, Jiwajinda S, Ohigashi H (2004) Zerumbone, a sesquiterpene in subtropical ginger suppresses tumouriniation and promotion stages in ICR mice. Int J Cancer 110:481–490
Nakamura Y, Yoshida C, Murakami A, Ohigashi H, Osawa T, Uchida K (2004) Zerumbone, a tropical ginger sesquiterpene, activates phase II drug metabolizing enzymes. FEBS Lett 572(1–3):245–250
Nakatani N, Jitoe A, Masuda T, Yonemori S (1991) Flavonoid constituents of Zingiber zerumbet Smith. Agric Biol Chem 2:455–460
Neeraj M, Chandanamali P, Naoaki F (2009) Hedgehog-Gli signaling pathway inhibitors as anticancer. Agents J Med Chem 52(13):3829–3845
Nigam LC, Levi L (1963a) Zerumbone down-regulates chemokine receptor CXCR4 expression leading to inhibition of CXCL 12-induced I NVASION of breast and pancreatic tumor cells. Can J Chem 41:1726–1730
Nishino H, Nishino A, Takayasu J, Hasegawa T, Iwashima A, Hirabayashi K, Iwata S, Shibata S (1988) Inhibition of the tumour promoting action of 12-O-tetradecanoylphorbol-13-asetate by some oleane-type triterpenoid compounds. Cancer Res 48:5210
Norulaini NAN, Anuar O, Omar AKM, Abbas FMA, Karkhi, Wahyu B, Setianto, Fatehah MO, Sahenaand SMZ (2009) Optimization of SC–CO2 extraction of zerumbone from Zingiber zerumbet (L) Smith. Food Chem 114(2):702–705
Obara Y (2006) Development of antidementia drugs related to neurotrophic factors. Yakugaku Zasshi 126:747–755
Ohigashi H, Murakami A (2002) Redox-regulated mechanism may account for zerumbone’s ability to suppress cancer cell proliferation. Carcinogenesis 23(12):1963
Oliveros MB, Cantoria MC (1982) Isolation, purification and characterization of antimicrobial principle from Zingiber zerumbet. Smith Int J Crude Drug Res 203:141–153
Ormerod MG, Neill CO, Robertson D, Kelland LR, Harrap KR (1996) Cisdiaminedichloroplatinum-induced cell dead through apoptosis in sensitive and resistant human ovarian carcinoma cell lines. Cancer Chemother Pharmacol 37:463–471
Ozaki Y, Kawahara N, Harada M (1991) Anti-inflammatory effect of Zingiber cassumunar Roxb and its active principles. Chem Pharm Bull 39:2353–2356
Peri LM (1980) Medicinal plants of East and South East Asia. Attributed properties and uses. MIT press, Cambridge
Ramaswami SK, Bhattacharyya SC (1962) Terpenoids—XXXI: Isolation of humulene monoxide and humulenedioxide. Tetrahedron 18:5575–5579
Rana VS, Verdeguer M, Blazquez MA (2008) Comparative study on the rhizomes essential oil of three Zingiber species from Manipur. Indian perfumer 52:17–18
Rasmos S, Alia M, Bravo L, Goya L (2005) Comparative effects of food derived polyphenols on the viability and apoptosis of a human hepatoma cell line (HepG2). J Agric Food Chem 53:1271–1280
Rodriguez AM, Enriz RD, Santagata LN, Jauregui EA, Pestchanker MJ, Giordano OS (1997) Structure-cytoprotective activity relationship of simple molecules containing an alpha, beta-unsaturated carbonyl system. J Med Chem 40:1827–1834
Roosterman D, Goerge T, Schneider SW, Bunnett NW, Steinhoff M (2006) Neuronal control of skin function: the skin as a neuroimmunoendocrine organ. Physiol Rev 86:1309–1379
Rout KK, Mishra SK, Sherma J (2009) Development and validation of an HPTLC method for analysis of Zerumbone, the anticancer marker from Zingiber zerumbe. Acta Chromatographica 3:443–452
Sharifah S, Handayani ST, Hawariah LPA (2007) Zerumbone induced apoptosis in liver cancer cells via modulation of Bax/Bcl-2 ratio. Cancer Cell Int 7:1–11
Sherma J (2010) Planar chromatography. Anal Chem 82:4895–4910
SiewKiat T, Richard P (2006) Screening of selected Zingiberaceae extracts for dengue-2 virus protease inhibitory activities. Sun Acad J 3:1–7
Somchit MN, Shukriyah MH (2005) Anti-inflammatory property of ethanol and water extracts of Z. zerumbet. Indian Pharmacol 35:181–182
Srivastava AK, Srivastava SK, Shah NC (2000) J Essent Oil Res 12:595–597
Sulaiman MR, Perimal EK, Zakaria ZA, Mokhtar F, Lajis NH, Israf DA (2009) Preliminary analysis of the antinociceptive activity of zerumbone. Fitoterpia 80:230–232
Supachai Y, Sung B, Pornngarm L, Bharat BA (2009) Zerumbone induces TRAIL-induced apoptosis through the induction of death receptors in human colon cancer cells: evidence for an essential role of reactive oxygen species. Cancer Res 69(16):6581–6589
Supinya T, Sanan S (2007) Antiallergic activity of some selected plants in the zingiberaceae family. J Ethnopharmacol 109:535–538
Supinya T, Sardsaengjun C, Itchayapruk J, Chaitongruk P (1997) Studies on the volatile oil components in Zingiber zerumbet smith rhizomes by gas chromatography. J Sci Technol (Thailand) 19(2):197–202
Szabolcs A, Tiszlavicz L, Kaszaki J, Posa A, Berko A, Varga IS, Boros I, Szuts V, Lonovics J (2007) Zerumbone exerts a beneficial effect on inflammatory parameters of cholecystokinin octapeptide-induced experimental pancreatitis but fails to improve histology. Pancrease 35(30):249–255
Taha MME, Abdula BA, Abdullah R, Ibrahimc TAT, Abdelwahaba SI, Mohana S (2010) Potential chemoprevention of diethylnitrosamine-initiated and 2-acetylaminofluorene-promoted hepatocarcinogenesis by zerumbone from the rhizomes of the subtropical ginger (Zingiber zerumbet). Chem Biol Interact 186(3):295–305
Takada Y, Murakami A, Agarwal BB (2005) Zerumbone abolishes NF-kappa B and I Kappa Balpha kinase activation leading to suppression of anti-apoptotic and metastatic gene expression, upregulation of apoptosis and down regulation of invasion. Oncogene 17:122–130
Tanaka T, Shimizu M, Kohno H, Yoshitani S, Hideki M (2001) Chemopreventive of azoxymethane-induced rat abberant crypt foci by dietary zerubone isolated from Zingiber zerumbet. Life Sci 69:1935–1945
Thebpatiphat (1984) Zingiber Zerumbet (L)J.E. Smith from phathalung province Thailand. J Sci Res 9(1):116–124
Varier NS (1944) Chemical examination of the rhizomes of Zingiber zerumbet Smith. Proc Math Sci 20(5):5257–5260
Vimala S, Norhanom AW, Yadav M (1999) Antitumour promoter activity in Malaysian ginger rhizobia used in traditional medicine. Br J Cancer 80:10–116
Voravuthikunchai VP, Limsuwan S, Suparol O, Subhadhirasakul S (2006) Antibacterial activity of extracts from family Zingiberaceae against food borne pathogens. J Food Safety 26:325–334
Wutthithamavet W (1997) Thai traditional medicine. Odean Store Press, Bangkok, p 155
Xian M, Ito K, Nakazato T et al (2007) Zerumbone, a bioactive sesquiterpene, induces G2/M cell cycle arrest and apoptosis in leukemia cells via a Fas- and mitochondria mediated pathway. Cancer Sci 98:118–126
Zakaria Z, Mohamad AAS, Chear CT, Wong YY, Israf DA, Sulaiman MR (2010) Anti-inflammatory and antinociceptive activities of Zingiber zerumbet methanol extract in experimental model systems. Med Princ Pract 19:287–294
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Singh, C.B., Nongalleima, K., Brojendrosingh, S. et al. Biological and chemical properties of Zingiber zerumbet Smith: a review. Phytochem Rev 11, 113–125 (2012). https://doi.org/10.1007/s11101-011-9222-4
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DOI: https://doi.org/10.1007/s11101-011-9222-4