International Journal of Clinical Pharmacy

, Volume 39, Issue 4, pp 669–673 | Cite as

Prevalence and correlates of inappropriate use of benzodiazepines in Kosovo

  • Zejdush TahiriEmail author
  • Suela Kellici
  • Iris Mone
  • Driton Shabani
  • Musa Qazimi
  • Genc Burazeri
Short Research Report



In post-war Kosovo, the magnitude of inappropriate use of benzodiazepines is unknown to date.


The aim of this study was to assess the prevalence and correlates of continuation of intake of benzodiazepines beyond prescription (referred to as “inappropriate use”) in the adult population of Gjilan region in Kosovo.


A cross-sectional study was conducted in Gjilan region in 2015 including a representative sample of 780 individuals attending different pharmacies and reporting use of benzodiazepines (385 men and 395 women; age range 18–87 years; response rate: 90%). A structured questionnaire was administered to all participants inquiring about the use of benzodiazepines and socio-demographic characteristics.


Overall, the prevalence of inappropriate use of benzodiazepines was 58%. In multivariable-adjusted models, inappropriate use of benzodiazepines was significantly associated with older age (OR 1.7, 95% CI 1.1–2.7), middle education (OR 1.8, 95% CI 1.2–2.7), daily use (OR 1.4, 95% CI 1.1–2.0) and addiction awareness (OR 2.7, 95% CI 2.0–3.8). Furthermore, there was evidence of a borderline relationship with rural residence (OR 1.2, 95% CI 0.9–1.7).


Our study provides novel evidence about the prevalence and selected correlates of inappropriate use of benzodiazepines in Gjilan region of Kosovo. Health professionals and policymakers in Kosovo should be aware of the magnitude and determinants of drug misuse in this transitional society.


Addiction Benzodiazepines Inappropriate use of drugs Kosovo 




Conflicts of interest



  1. 1.
    Petitjean S, Ladewig D, Meier CR, Amrein R, Wiesbeck GA. Benzodiazepine prescribing to the Swiss adult population: results from a national survey of community pharmacies. Int Clin Psychopharmacol. 2007;22:292–8.CrossRefPubMedGoogle Scholar
  2. 2.
    Joint Formulary Committee. British National Formulary 60. London: BMJ Publishing Group & Royal Pharmaceutical Society of Great Britain; 2010. ISBN 13: 9780853699316.Google Scholar
  3. 3.
    Ashton H. The diagnosis and management of benzodiazepine withdrawal. Curr Opin Psychiatry. 2005;18:249–55.CrossRefPubMedGoogle Scholar
  4. 4.
    Williams H, Oyeffeso A, Ghodse AH. Benzodiazepine misuse and dependence among opiate addicts in treatment. Ir J Psychol Med. 1996;13:62–4.CrossRefGoogle Scholar
  5. 5.
    Levine DA. ‘Pharming’: the abuse of prescription and over-the-counter drugs in teens. Curr Opin Pediatr. 2007;19:270–4.CrossRefPubMedGoogle Scholar
  6. 6.
    Jerliu N, Toci E, Burazeri G, Ramadani N, Brand H. Socioeconomic conditions of elderly people in Kosovo: a cross-sectional study. BMC Public Health. 2012;12:512.CrossRefPubMedPubMedCentralGoogle Scholar
  7. 7.
    The World Bank. Europe and Central Asia Region. Poverty Reduction and Economic Management Unit. Statistical Office of Kosovo. Consumption Poverty in the Republic of Kosovo, in 2009. Western Balkans Programmatic Poverty Assessment; 2011. Accessed 18 Nov 2016.
  8. 8.
    Kellici S, Hoti E, Burazeri G. Level and factors of benzodiazepines misuse in Albania. Int J Clin Pharm. 2013;35:323–6.CrossRefPubMedGoogle Scholar
  9. 9.
    Magrini N, Vaccheri A, Parma E, D’Alessandro R, Bottoni A, Occhionero M, Montanaro N. Use of benzodiazepines in the Italian general population: prevalence, pattern of use and risk factors for use. Eur J Clin Pharmacol. 1996;50:19–25.CrossRefPubMedGoogle Scholar
  10. 10.
    Ohayon MM, Caulet M, Priest RG, Guilleminault C. Psychotropic medication consumption patterns in the UK general population. J Clin Epidemiol. 1998;51:273–83.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing 2017

Authors and Affiliations

  • Zejdush Tahiri
    • 1
    • 2
    Email author
  • Suela Kellici
    • 1
  • Iris Mone
    • 1
  • Driton Shabani
    • 1
    • 3
  • Musa Qazimi
    • 1
    • 2
  • Genc Burazeri
    • 4
  1. 1.Faculty of MedicineUniversity of MedicineTiranaAlbania
  2. 2.Principal Family Medicine CenterGjilanKosovo
  3. 3.Department of Pharmacy, Faculty of MedicineUniversity of PristinePristineKosovo
  4. 4.Department of International Health, Faculty of Health, Medicine and Life Sciences, School for Public Health and Primary Care (CAPHRI)Maastricht UniversityMaastrichtThe Netherlands

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