International Journal of Clinical Pharmacy

, Volume 38, Issue 1, pp 7–9 | Cite as

Colloidal silica-induced hypersensitivity: myth or reality

  • Nadia Ben FredjEmail author
  • Najeh Ben Fadhel
  • Amel Chaabane
  • Zohra Chadly
  • Haifa Ben Romdhane
  • Abderrazzek Boughattas
  • Karim Aouam
Case Report


Background Many excipients have been reported to induce drug hypersensitivity (e.g. colouring additives, preservatives). Colloidal silica has never been reported to induce drug hypersensitivity reactions. Case report We report herein a 40-year-old patient who developed a skin eruption 2 days after Voltarene® (diclofenac) intake, confirmed by a positive patch test. Investigation of cross reactivity, assessed by patch testing to other non steroidal anti-inflammatory drugs, have showed a positive reaction only to piroxicam (Piroxen®), ketoprofen (Oki®) and indometacin (Indocid®). A hypersensivity to colloidal silica, a common excipient, was suspected. A patch test to this compound was performed showing a positive reaction. Conclusion Colloidal silica, a compound widely used in drug manufacturing, could be another culprit excipient in inducing skin hypersensitivity reactions.


Colloidal silica Drug hypersensitivity reaction Patch test 



The authors are greatly indebted to Professor Adel Rdissi for his help with improving the language used in this article.



Conflicts of interest



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Copyright information

© Koninklijke Nederlandse Maatschappij ter bevordering der Pharmacie 2015

Authors and Affiliations

  • Nadia Ben Fredj
    • 1
    Email author
  • Najeh Ben Fadhel
    • 1
  • Amel Chaabane
    • 1
  • Zohra Chadly
    • 1
  • Haifa Ben Romdhane
    • 1
  • Abderrazzek Boughattas
    • 1
  • Karim Aouam
    • 1
  1. 1.Pharmacology departmentFaculty of MedicineMonastirTunisia

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