Medicine information leaflets for non-steroidal anti-inflammatory drugs in Thailand
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Background The importance of promoting the use of patient-oriented medicines leaflets is recognized in many countries. Leaflets should include basic information plus specific warnings, and be provided with all medicines, but there is little attempt at enforcement of these requirements in Thailand. Objective To determine content and availability of Thai information leaflets for nonsteroidal anti-inflammatory drugs (NSAIDs). Methods Leaflets for all NSAIDs available for purchase from 34 pharmacies in a large city were evaluated against a checklist and number of leaflets assessed against number of medicine packs available in each pharmacy. Results Of the 76 leaflets for ten different NSAIDs, 67 (88 %) were for locally manufactured products. Only 22 % of 76 leaflets were sufficient in number for distribution with medicines, while only 4 % had patient-oriented leaflets. No leaflet covered all topics in the checklist. Less than half included safety information, such as contraindications (46 %), precautions (47 %), and adverse drug reactions (34 %). Locally-produced leaflets provided less information than those for originator products and no leaflet included all the warnings required by Thai regulations. Conclusion This study illustrates the variable availability and quality of NSAID information leaflets. The lack of accessible essential information about medicines in Thailand requires urgent attention to enable patients to minimise adverse reactions.
KeywordsInformation leaflets Non-steroidal anti-inflammatory drugs Drug safety information Thailand
The authors would like to thank all community pharmacists who supplied the information leaflets in this study.
This work received financial support from Khon Kaen University Integrated Multidisciplinary Research Cluster [Grant No. MIH-2554-Ph.D-07] and the Graduate School of Khon Kaen University [Grant No. 55222103].
Conflicts of interest
The authors declare no conflict of interest.
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