International Journal of Clinical Pharmacy

, Volume 38, Issue 1, pp 70–79 | Cite as

Continuous versus intermittent piperacillin/tazobactam infusion in infection due to or suspected pseudomonas aeruginosa

  • Jesús Cotrina-LuqueEmail author
  • Maria Victoria Gil-Navarro
  • Héctor Acosta-García
  • Eva Rocío Alfaro-Lara
  • Rafael Luque-Márquez
  • Margarita Beltrán-García
  • Francisco Javier Bautista-Paloma
Research Article


Background There is lack of information on the efficacy and safety of piperacillin–tazobactam administered by continuous infusion. Objective The aim of this study was to investigate whether continuous infusion of piperacillin–tazobactam is superior in terms of efficacy to a 30 % higher dose administered by intermittent infusion to treat suspected or confirmed infection due to Pseudomonas aeruginosa. Setting Multicenter clinical trial with 11 third level Spanish hospitals. Method Randomized, double-blind parallel-group clinical trial, controlled by conventional administration of the drug. Patients randomly assigned in a 1:1 ratio to receive piperacillin–tazobactam as continuous infusion (CI) or intermittent (II). Main outcome measure Primary efficacy endpoint was percentage of patients having a satisfactory clinical response at completion of treatment, defined as clinical cure or clinical improvement. Adverse events were reported. Results 78 patients were included, 40 in the CI group and 38 in the II group. Mean (standard deviation) duration of treatment was 7 (±4.44) days. 58 patients (74.4 %) experienced cure or improvement at the end of the treatment. There were no statistical differences in cure rates between the two treatment arms and no adverse events were reported. Conclusion Continuous infusion of piperacillin–tazobactam is an alternative administration drug method at least similar in efficacy and safety to conventional intermittent infusion. Multivariate analysis is needed to determine whether continuous administration might be more beneficial than intermittent in certain patient subgroups.


Continuous administration Intermittent administration Piperacillin/tazobactam Pseudomonas aeruginosa 



We thank the staff of the Pharmacy Department of Virgen del Rocio Hospital for their collaboration with this study and all the staff of each participating hospital.


The Ministry of Health and Social Policy of Spain supported this work within the 2010 initiative for funding of independent clinical research in medications, with no commercial interest (File Number: EC10-288).

Conflicts of interest

The authors declare they have not conflicts of interest.


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Copyright information

© Koninklijke Nederlandse Maatschappij ter bevordering der Pharmacie 2015

Authors and Affiliations

  • Jesús Cotrina-Luque
    • 1
    Email author
  • Maria Victoria Gil-Navarro
    • 1
  • Héctor Acosta-García
    • 1
  • Eva Rocío Alfaro-Lara
    • 1
  • Rafael Luque-Márquez
    • 2
  • Margarita Beltrán-García
    • 3
  • Francisco Javier Bautista-Paloma
    • 1
  1. 1.Pharmacy DepartmentHospital Universitario Virgen del RocioSevilleSpain
  2. 2.Internal Medicine DepartmentHospital Universitario Virgen del RocioSevilleSpain
  3. 3.Pharmacy DepartmentHospital Universitario Virgen MacarenaSevilleSpain

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