Abstract
Background
The Good Prescribing Practice for Clinicians guidelines were published in 2002 in Ireland to guide General Practitioners about prescribing benzodiazepines. There has been no research to-date to measure compliance by General Practitioners. Inappropriate prescribing to minors may result in increased use or misuse of benzodiazepines.
Objective
The purpose of this study was to evaluate the prescribing of benzodiazepines to minors in Ireland against the Good Prescribing Practice for Clinicians guidelines.
Method
Data for medicines dispensed between January 2009 and December 2012 from the Health Intelligence Ireland database were accessed and analysed. This database contains information about government-subsidised community-pharmacy-dispensed medicines.
Results
Benzodiazepine prescribing to minors increased by 10.2 % between 2009 and 2012. Almost 15 % of patients (n = 2193) were prescribed benzodiazepines for greater than four weeks; which contravenes the guidelines. Approximately half (51.4 %) of prescribers who contravened this guideline, prescribed all their benzodiazepines in quantities of greater than one week, against the recommendations of the guidelines.
Conclusion
The consequences of prescribing against National Guidelines can result in patients who become long-term benzodiazepine users and thus place an increased burden upon the healthcare system. The reasons for non-compliance by GPs should be investigated to find solutions.
References
Longo L, Johnson B. Addiction: Part I. Benzodiazepines-side effects, abuse risk and alternatives. Am. Fam. Phys. 2000;61(7):2121.
Carlsten A, Waern M. Are sedatives and hypnotics associated with increased suicide risk of suicide in the elderly? BMC Geriatr. 2009;9(1):20–6.
Pae C-U, Koh JS, Lee S-J, Han C, Patkar AA, Masand PS. Association of sedative–hypnotic medications with suicidality. Expert Rev Neurother. 2011;11(3):345–9.
Youssef N, Rich C. Does acute treatment with sedatives/hypnotics for anxiety in depressed patients affect suicide risk? A literature review. Ann. Clin. Psychiatry 2008;20(3):157–69.
Department of Health and Children. Benzodiazepines: good practice guidelines for clinicians. Dublin: Department of Health and Children; 2002. Accessed 12 May 2015. http://www.drugsandalcohol.ie/5348/1/DOHC_Benzo_committee.pdf.
Health Intelligence Unit. Health Atlas Ireland 2013. https://www.healthatlasireland.ie/.
Smith AJ, Tett SE. How do different age groups use benzodiazepines and antidepressants? Analysis of an Australian administrative database, 2003–2006. Drugs Aging. 2009;26(2):113–22.
Steffenak AK, Wilde-Larsson B, Nordstrom G, Skurtveit S, Hartz I. Increase in psychotropic drug use between 2006 and 2010 among adolescents in Norway: a nationwide prescription database study. J Clin Epidemiol. 2012;4:225–31.
McLean CP, Asnaani A, Litz BT, Hofmann SG. Gender differences in anxiety disorders: prevalence, course of illness, comorbidity and burden of illness. J Psychiatr Res. 2011;45(8):1027–35.
Linehan C, Kerr MP, Walsh PN, Brady G, Kelleher C, Delanty N, et al. Examining the prevalence of epilepsy and delivery of epilepsy care in Ireland. Epilepsia. 2010;51(5):845–52.
Acknowledgments
The authors acknowledge Health Intelligence Ireland for granting permission to access their data. We also acknowledge the assistance of the Pharmaceutical Care Research Group of the School of Pharmacy in University College Cork.
Funding
This research received no external funding.
Conflicts of interest
The authors declare that they have no conflict of interest.
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Murphy, K.D., Sahm, L.J., McCarthy, S. et al. Benzodiazepine prescribing guideline adherence and misuse potential in Irish minors. Int J Clin Pharm 37, 749–752 (2015). https://doi.org/10.1007/s11096-015-0138-8
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DOI: https://doi.org/10.1007/s11096-015-0138-8