International Journal of Clinical Pharmacy

, Volume 37, Issue 1, pp 1–3 | Cite as

Unpredictable drug reaction in a child with Cornelia de Lange syndrome

  • Marija StevicEmail author
  • Irina Milojevic
  • Zlatko Bokun
  • Dusica Simic
Case Report


Case description

Preoperative use of midazolam sedation is mandatory during induction of anesthesia in noncooperative and hyperactive children to prevent possible obstacles. Unusual drug reactions rarely occur in patients undergoing anesthesia or in intensive care unit. This report describes an unpredictable drug reaction after a routine midazolam premedication in a patient with no history of allergy. There has been no literature data yet to show that midazolam can provoke respiratory problems in patients with Cornelia de Lange Syndrome.


In our opinion midazolam should be avoided in patients with Cornelia de Lange Syndrome, which we enforced after first unpredictable reaction.


Anesthesia Child Cornelia de Lange syndrome Adverse drug reaction Predictability 




Conflicts of interest



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Copyright information

© Koninklijke Nederlandse Maatschappij ter bevordering der Pharmacie 2014

Authors and Affiliations

  • Marija Stevic
    • 1
    Email author
  • Irina Milojevic
    • 1
  • Zlatko Bokun
    • 2
  • Dusica Simic
    • 3
  1. 1.Department of AnesthesiaUniversity Children’s HospitalBelgradeSerbia
  2. 2.Department of Minimally Invasive SurgeryZvezdara University Clinical HospitalBelgradeSerbia
  3. 3.Department of Anesthesia, Medical FacultyUniversity of BelgradeBelgradeSerbia

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