International Journal of Clinical Pharmacy

, Volume 35, Issue 4, pp 507–509 | Cite as

Bevacizumab versus ranibizumab: why are we not playing the joker?

  • Roberto Banfi
  • Francesco Attanasio
  • Nadia Palazzi
  • Silvia Colombini
  • Tiziana Falai
  • Michele Cecchi
  • Gianni Virgili



We would like to thank the collegues of the Pharmacy Department and the residents of the School of Hospital Pharmacy of Florence.

Conflicts of interest

There are no conflict of interests.


  1. 1.
    CATT Research Group, Martin DF, Maguire MG, Ying GS, Grunwald JE, Fine SL, Jaffe GJ. Ranibizumab and bevacizumab for neovascular age-related macular degeneration. N Engl J Med. 2011;364(20):1897–908. doi:  10.1056/NEJMoa1102673. Epub 2011 Apr 28. PubMed PMID: 21526923; PubMed Central PMCID: PMC3157322.Google Scholar
  2. 2.
    Comparison of Age-related Macular Degeneration Treatments Trials (CATT) Research Group, Martin DF, Maguire MG, Fine SL, Ying GS, Jaffe GJ, Grunwald JE, Toth C, Redford M, Ferris FL 3rd. Ranibizumab and bevacizumab for treatment of neovascular age-related macular degeneration: two-year results. Ophthalmology. 2012;119(7):1388–98. doi:  10.1016/j.ophtha.2012.03.053. Epub 2012 May 1. PubMed PMID: 22555112; PubMed Central PMCID: PMC3389193.Google Scholar
  3. 3.
    Sears J, Bena J, Singh AD. CATT: Into the eye of a tiger. Br J Ophthalmol. 2011 ;95(6):761. doi:  10.1136/bjophthalmol-2011-300406. PubMed PMID: 21602481.Google Scholar
  4. 4.
    Cheung N, Lam DS, Wong TY. Anti-vascular endothelial growth factor treatment for eye diseases. BMJ. 2012;1(344):e2970. doi: 10.1136/bmj.e2970.CrossRefGoogle Scholar
  5. 5.
    Godlee F. Editor’s choice, Avastin versus Lucentis. BMJ. 2012;344:e3162.CrossRefGoogle Scholar
  6. 6.
    Bowler GS, Fayers T, Gouws P. 5.7 times more expensive than liquid gold. Br J Ophthalmol. 2012;96(7):1046. Epub 2011 Nov 28.Google Scholar
  7. 7.
    Torjesen I. Why using Avastin for eye disease is so difficult. BMJ. 2012;1(344):e3012. doi: 10.1136/bmj.e3012.CrossRefGoogle Scholar
  8. 8.
    Ng DS, Kwok AKh, Chan CW, Li WW. Intravitreal bevacizumab: safety of multiple doses from a single vial for consecutive patients. Hong Kong Med J. 2012;18(6):488–95. PubMed PMID: 23223649.Google Scholar
  9. 9.
    Paul M, Vieillard V, Roumi E, Cauvin A, Despiau MC, Laurent M, Astier A. Long-term stability of bevacizumab repackaged in 1 mL polypropylene syringes for intravitreal administration. Ann Pharm Fr. 2012;70(3):139–54. doi:  10.1016/j.pharma.2012.03.006. Epub 2012 May 11. PubMed PMID: 22655582.
  10. 10.
    Gonzalez S, Rosenfeld PJ, Stewart MW, Brown J, Murphy SP. Avastin doesn’t blind people, people blind people. Am J Ophthalmol. 2012;153(2):196–203.e1. doi:  10.1016/j.ajo.2011.11.023. PubMed PMID: 22264942.
  11. 11.
    Bakri SJ, Snyder, Pulido JS, McCannel CA, Weiss WT, Singh RJ. Six-month stability of bevacizumab (Avastin) binding to vascular endothelial growth factor after withdrawal into a syringe and refrigeration or freezing. Retina. 2006;26(5):519–22. PubMed PMID: 16770257.PubMedCrossRefGoogle Scholar
  12. 12.
    Georgalas I, Koutsandrea C. Avastin versus Lucentis. Approve bevacizumab for use in eye disease in cash strapped times. BMJ. 2012;345:e3162. (2 May).Google Scholar
  13. 13.
    Montastruc JL. Social pharmacology: a new topic in clinical pharmacology. Therapie. 2002;57(5):420–6. Review. French. PubMed PMID: 12611195.Google Scholar
  14. 14.
    Garattini S, Bertelè V. Bevacizumab and ranibizumab. Matter of public interest. Istituto di Ricerche Farmacologiche Mario Negri, Milano. BMJ. 2010;341:c372.Google Scholar
  15. 15.
    McCartney M. Off-label prescribing in macular degeneration. BMJ 2011; 343:d6778.Google Scholar
  16. 16.
    Lucentis versus Avastin: needs must or devil drives? Bandolier “Evidence based thinking about health care” May 2007;159–5.

Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  • Roberto Banfi
    • 1
  • Francesco Attanasio
    • 1
  • Nadia Palazzi
    • 1
  • Silvia Colombini
    • 1
  • Tiziana Falai
    • 1
  • Michele Cecchi
    • 1
  • Gianni Virgili
    • 2
  1. 1.PharmacyCareggi University HospitalCareggiItaly
  2. 2.Eye ClinicUniversity of FlorenceFlorenceItaly

Personalised recommendations