International Journal of Clinical Pharmacy

, Volume 35, Issue 3, pp 319–322 | Cite as

HLA typing in Brazilian boys with aromatic antiepileptic drug-induced DRESS

  • Walderez Penteado Gaeti
  • Paulo Roque Obreli-NetoEmail author
  • Ricardo A. Moliterno
  • Gina Bressan Schiavon
  • Roberto Kenji Nakamura Cuman
Case Report


Cases description We report two cases of drug rash with eosinophilia and systemic symptoms (DRESS) associated with the use of carbamazepine and phenytoin in Brazilian boys tested for human leukocyte antigen (HLA) class I and II alleles. The clinical manifestations were similar: a maculopapular eruption progressing to exfoliative erythroderma, fever, and lymphadenopathy. Leukocytosis, atypical lymphocytes, and liver injury were also observed. Assessment of causality using the Naranjo algorithm established a “probable” relationship (score 6) in both cases. Case 1 patient presented the following results of HLA typing: HLA-A*02,29 B*44,50 C*06,16 DRB1*01,07 DQA1*01,02. Case 2 patient presented the following results of HLA typing: HLAA*23,24 B*39,53 C*04,07 DRB1*04,08 DQA1*03,05 DQB1*03,03. Conclusion Neither of the cases reported here presented HLA typing similar to that strongly associated with the occurrence of DRESS in Asian or European patients.


Adverse drug reactions Antiepileptic drugs Brazil Dress syndrome HLA Antigens 




Conflicts of interest



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Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  • Walderez Penteado Gaeti
    • 1
  • Paulo Roque Obreli-Neto
    • 1
    Email author
  • Ricardo A. Moliterno
    • 2
  • Gina Bressan Schiavon
    • 3
  • Roberto Kenji Nakamura Cuman
    • 1
  1. 1.Department of Pharmacology and TherapeuticsState University of MaringaMaringáBrazil
  2. 2.Immunogenetic LaboratoryState University of MaringaMaringáBrazil
  3. 3.Department of MedicineState University of MaringaMaringáBrazil

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