International Journal of Clinical Pharmacy

, Volume 35, Issue 3, pp 316–318 | Cite as

Unusual drug reaction between valproate sodium and meropenem

  • Hyonok YoonEmail author
  • Diana H. Kim
Case Report


Case We describe here a rare case in which valproic acid (VPA) levels were affected by ertapenem but not by meropenem even though ertapenem and meropenem are in the same carbapenem class. A 68-year-old Filipino male treated with valproate for epilepsy and ertapenem for an infectious disease had decreased VPA levels during the first day of ertapenem therapy. His VPA level increased soon after terminating ertapenem therapy. Two types of carbapenems had different drug reactions with concomitant use of VPA in this patient. Conclusions Closer monitoring of VPA concentrations are necessitated using carbapenems for treating infection in patients being administered VPA. Another option is the use of anti-epileptic drugs other than VPA if concomitant use with a carbapenem is warranted.


Drug interaction Epilepsy Ertapenem Meropenem Valproic acid 






Conflicts of interest

None to declare.


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Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  1. 1.Department of Clinical Pharmacy, College of PharmacyChonnam National UniversityGwangjuRepublic of Korea
  2. 2.Department of Pharmacotherapeutics, College of Pharmacy, Research Institute of Pharmaceutical SciencesGyeongsang National UniversityJinju, GyeongnamRepublic of Korea
  3. 3.Department of Biology, College of Arts and SciencesUniversity of PennsylvaniaPhiladelphiaUSA

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