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Predictors of the use of medications before and during pregnancy

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Abstract

Background Drug use in pregnancy is often reason of concern for mothers and their physicians. However, only few studies investigated predictors of drug use in pregnancy. Objectives To examine maternal characteristics as predictors of medication use in the 6 months before pregnancy and during the first 6 months of pregnancy. To examine whether prescription and over-the-counter (OTC) medication use in the 6 months before pregnancy had an impact on medication use in pregnancy. Setting Six maternity care units and five community pharmacies. Method Data were collected using a specially designed self-reported questionnaire during the period March 2009–March 2010. Logistic regression was used to identify factors associated with medication use. Main outcome measure Adjusted odds ratios (aOR) and 95 % confidence intervals (CI) were used as association measures. Results A total of 236 women were included in the analysis. After controlling for maternal characteristics, parity of more than one was associated with lower prescription medication use in pregnancy (aOR 0.46; 95 % CI 0.22–0.93), higher household income with higher OTC medication use before pregnancy (aOR 3.13; 95 % CI 1.22–8.00), and miscarriage with higher C and D Food and Drug Administration (FDA) risk category medication use in pregnancy (aOR 3.65; 95 % CI 1.30–10.25). Prescription medication use before pregnancy was associated with higher prescription medication use in pregnancy (aOR 2.49; 95 % CI 1.12–5.52), OTC medication use before pregnancy with higher OTC medication use in pregnancy (aOR 35.95; 95 % CI 7.95–162.49), and C and D FDA risk category medication use before pregnancy with the same category medication use in pregnancy (aOR 3.54; 95 % CI 1.23–10.17). Conclusion Different maternal characteristics were shown as predictors of medication use before and during pregnancy. However, medication use before pregnancy was shown as the most important predicting factor for the medication use in pregnancy.

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References

  1. Daw JR, Hanley GE, Greyson DL, Morgan SG. Prescription drug use during pregnancy in developed countries: a systematic review. Pharmacoepidemiol Drug Saf. 2010;20(9):895–902.

    Google Scholar 

  2. Glover DD, Amonkar M, Rybeck BF, Tracy TS. Prescription, over-the-counter, and herbal medicine use in a rural, obstetric population. Am J Obstet Gynecol. 2003;188(4):1039–45.

    Article  PubMed  Google Scholar 

  3. Black RA, Hill AD. Over-the-counter medications in pregnancy. Am Fam Physician. 2003;67(12):2517–24.

    PubMed  Google Scholar 

  4. Cleary BJ, Butt H, Strawbridge JD, Gallagher PJ, Fahey T, Murphy DJ. Medication use in early pregnancy-prevalence and determinants of use in a prospective cohort of women. Pharmacoepidemiol Drug Saf. 2010;19(4):408–17.

    PubMed  Google Scholar 

  5. Donati S, Baglio G, Spinelli A, Grandolfo ME. Drug use in pregnancy among Italian women. Eur J Clin Pharmacol. 2000;56(4):323–8.

    Article  PubMed  CAS  Google Scholar 

  6. Bonassi S, Magnani M, Calvi A, Repetto E, Puglisi P, Pantarotto F, et al. Factors related to drug consumption during pregnancy. Acta Obstet Gynecol Scand. 1994;73(7):535–40.

    Article  PubMed  CAS  Google Scholar 

  7. Olesen C, Thrane N, Henriksen T, Ehrenstein V, Olsen J. Associations between socio-economic factors and the use of prescription medication during pregnancy. Eur J Clin Pharmacol. 2006;62(7):547–53.

    Article  PubMed  Google Scholar 

  8. Nordeng H, Eskild A, Nesheim BI, Aursnes I, Jacobsen G. Drug use during early pregnancy. Eur J Clin Pharmacol. 2001;57(3):259–63.

    Article  PubMed  CAS  Google Scholar 

  9. Buitendijk S, Bracken MB. Medication in early pregnancy: prevalence of use and relationship to maternal characteristics. Am J Obstet Gynecol. 1991;165(1):33–40.

    Article  PubMed  CAS  Google Scholar 

  10. Statistical Office of the Republic of Serbia. Population: census of population, households and dwellings. Sex and age, data by localities. Belgrade 2003. ISBN: 86-84433-01-7. Available at: http://webrzs.stat.gov.rs/WebSite/Public/PageView.aspx?pKey=164. Accessed 01 Dec 2012.

  11. Djukic Lj. National formulary. Belgrade: Medicines and Medical Devices Agency of Serbia, 2010. ISSN: 1452-3337.

  12. Food and Drug Administration. Available at: http://www.accessdata.fda.gov/scripts/cder/drugsatfda/index.cfm. Accessed 05 Dec 2012.

  13. Briggs GG, Freeman RK, Yaffe SJ. Drugs in pregnancy and lactation: a reference guide to fetal and neonatal risk. 8th ed. Philadelphia: Lippincott Wiliams & Wilkins; 2008. ISBN: 978-0-7817-7876-3.

  14. Yang T, Walker MC, Krewski D, Yang Q, Nimrod C, Garner P, et al. Maternal characteristics associated with pregnancy exposure to FDA category C, D, and X drugs in a Canadian population. Pharmacoepidemiol Drug Saf. 2008;17(3):270–7.

    Article  PubMed  Google Scholar 

  15. Lee E, Maneno MK, Smith L, Weiss SR, Zuckerman IH, Wutoh AK, et al. National patterns of medication use during pregnancy. Pharmacoepidemiol Drug Saf. 2006;15(8):537–45.

    Article  PubMed  Google Scholar 

  16. Egen-Lappe V, Hasford J. Drug prescription in pregnancy: analysis of a large statutory sickness fund population. Eur J Clin Pharmacol. 2004;60(9):659–66.

    Article  PubMed  Google Scholar 

  17. Andrade SE, Gurwitz JH, Davis RL, Chan KA, Finkelstein JA, Fortman K, et al. Prescription drug use in pregnancy. Am J Obstet Gynecol. 2004;191(2):398–407.

    Article  PubMed  Google Scholar 

  18. Stephansson O, Granath F, Svensson T, Haglund B, Ekbom A, Kieler H. Drug use during pregnancy in Sweden—assessed by the prescribed drug register and the medical birth register. J Clin Epidemiol. 2011;3(1):43–50.

    Google Scholar 

  19. Engeland A, Bramness JG, Daltveit AK, Rønning M, Skurtveit S, Furu K. Prescription drug use among fathers and mothers before and during pregnancy. A population-based cohort study of 106,000 pregnancies in Norway 2004–2006. Br J Clin Pharmacol. 2008;65(5):653–60.

    Article  PubMed  Google Scholar 

  20. Bakker MK, Jentink J, Vroom F, Van Den Berg PB, De Walle HE, De Jong-Van Den Berg LT. Drug prescription patterns before, during and after pregnancy for chronic, occasional and pregnancy-related drugs in the Netherlands. BJOG. 2006;113(5):559–68.

    Article  PubMed  CAS  Google Scholar 

  21. Olesen C, Steffensen FH, Nielsen GL, De Jong-Van Den Berg L, Olsen J, Sørensen HT. Drug use in first pregnancy and lactation: a population-based survey among Danish women. Eur J Clin Pharmacol. 1999;55(2):139–44.

    Article  PubMed  CAS  Google Scholar 

  22. Riley EH, Fuentes-Afflick E, Jackson RA, Escobar GJ, Brawarsky P, Schreiber M, et al. Correlates of prescription drug use during pregnancy. J Womens Health. 2005;14(5):401–9.

    Article  Google Scholar 

  23. Bercaw J, Maheshwari B, Sangi-Haghpeykar H. The use during pregnancy of prescription, over-the-counter, and alternative medications among Hispanic women. Birth. 2010;37(3):211–8.

    Article  PubMed  Google Scholar 

  24. Rubin JD, Ferencz C, Loffredo C. Use of prescription and non-prescription drugs in pregnancy. Clin Pharmacol. 1993;46(6):581–9.

    CAS  Google Scholar 

  25. Morgan MA, Cragan JD, Goldenberg RL, Rasmussen SA, Schulkin J. Management of prescription and nonprescription drug use during pregnancy. J Matern Fetal Med. 2010;23(8):813–9.

    Article  Google Scholar 

  26. Hardy JR, Leaderer BP, Holford TR, Hall GC, Bracken MB. Safety of medications prescribed before and during early pregnancy in a cohort of 81,975 mothers from the UK general practice research database. Pharmacoepidemiol Drug Saf. 2006;15(8):555–64.

    Article  PubMed  Google Scholar 

  27. Andrade SE, Raebel MA, Morse AN, Davis RL, Chan KA, Finkelstein JA, et al. Use of prescription medications with a potential for fetal harm among pregnant women. Pharmacoepidemiol Drug Saf. 2006;15(8):546–54.

    Article  PubMed  Google Scholar 

  28. Lagoy CT, Joshi N, Cragan JD, Rasmussen SA. Medication use during pregnancy and lactation: an urgent call for public health action. J Womens Health. 2005;14(2):104–9.

    Article  Google Scholar 

  29. Ministry of Health Republic of Serbia. National Health Survey. Key Findings. Belgrade: 2006. Available at: http://www.batut.org.rs/download/publikacije/National%20Health%20Survey%20Serbia%202006.pdf. Accessed 02 Dec 2012.

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Acknowledgments

We are very grateful to the Associate Professor Natasa Bogavac Stanojevic, Department of Biochemistry, The University of Belgrade-Faculty of Pharmacy for her useful comments in the statistical analysis, and to Mrs. Zorica Bogdanovic for editing of the English.

Funding

This work is supported by the Ministry of Education and Science, Republic of Serbia, Project No. 41012, and Project No. 175064, 2011–2014.

Conflicts of interest

The authors declare no conflict of interest.

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Correspondence to Ljiljana Tasic.

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Odalovic, M., Vezmar Kovacevic, S., Nordeng, H. et al. Predictors of the use of medications before and during pregnancy. Int J Clin Pharm 35, 408–416 (2013). https://doi.org/10.1007/s11096-013-9750-7

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  • DOI: https://doi.org/10.1007/s11096-013-9750-7

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