Prescribing of zoledronic acid in a tertiary outpatient hospital setting
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Background Zoledronic acid (ZA) is an intravenous bisphosphonate approved for the prevention and treatment of cancer skeletal-related events. Objective Our aim was to analyze the prescription patterns of ZA in the cancer outpatient clinic. Method We performed a retrospective chart review of all patients who received at least 1 dose of ZA from January 2009 until December 2010 in our institution. The patients’ follow-up period was defined from the administration of the first dose until February 2011. Results The sample comprised 345 patients: 31.9 % had breast cancer, 14.5 % prostate cancer, 29.0 % multiple myeloma, and 24.6 % other solid tumors. A total of 4,546 doses were administered; 2,749 (60.5 %) without intravenous chemotherapy. 71.1 % of patients with breast cancer, 86 % with prostate cancer, 60 % with multiple myeloma and 44.6 % with other solid tumors, received ZA without intravenous chemotherapy throughout bisphosphonate treatment. Doses were adjusted in one-third of cases. Administration every 4-weeks was the most frequent schedule. Median duration of treatment varied between 15.0 months for breast cancer and 4.2 months for other solid tumors. Conclusion Most of ZA prescriptions in cancer outpatients followed the labeled indications. The percentage of ZA doses administered without intravenous chemotherapy was 60.5 %.
KeywordsBisphosphonates Outpatient care Prescription pattern Zoledronic acid Spain Tertiary hospital
Conflicts of interest
- 4.Hoer A, Goethe H, Barghout V, et al. Low persistency with oral bisphosphonates in cancer patients [poster]. Presented at: 5th European Oncology Nursing Society Spring Convention; April 20–22, 2006; Innsbruck, Austria. Abstract 2.Google Scholar
- 5.European Medicines Agency. Zometa (zoledronic acid) summary of product characteristics [online]. Available from URL: http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/000336/WC500051730.pdf. Accessed 30 Oct 2011.
- 7.Wardley A, Davidson N, Barrett-Lee P, Hong A, Mansi J, Dodwell D, et al. Zoledronic acid significantly improves pain scores and quality of life in breast cancer patients with bone metastases: a randomised, crossover study of community vs hospital bisphosphonate administration. Br J Cancer. 2005;92(10):1869–76.PubMedCrossRefGoogle Scholar
- 10.Rodriguez-Penin I, Lamas MJ, Iglesias-Santamaria A, Lema M, Bernardez B, Gonzalez-Pereira E, et al. Retrospective epidemiologic study to evaluate the pattern of use of biphosphonates in the treatment of bone metastasis in solid tumor cancer patients (REBIUS) [poster]. J Clin Oncol. 2010 Jun, 14 (28) (suppl; abstr e19667).Google Scholar