International Journal of Clinical Pharmacy

, Volume 35, Issue 3, pp 303–305 | Cite as

Methemoglobinemia and hemolytic anemia after rasburicase administration in a child with leukemia

  • T. BautersEmail author
  • V. Mondelaers
  • H. Robays
  • H. De Wilde
  • Y. Benoit
  • B. De Moerloose
Case Report


Case We report a case of simultaneous methemoglobinemia and hemolytic anemia, probably related to the use of rasburicase, in a child starting treatment for acute lymphoblastic leukemia (ALL). In addition, the patient developed symptoms of pancreatitis. All complications resolved after 3 days of supportive therapy. Conclusion Although usually well tolerated in pediatrics, physicians prescribing rasburicase should be aware of these possible life-threatening adverse reactions.


Clinical pharmacy Hemolytic anemia  Methemoglobinemia Pancreatitis Pediatric hemato-oncology Rasburicase 


Conflicts of interest

The authors have no conflicts of interest.


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Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  • T. Bauters
    • 1
    Email author
  • V. Mondelaers
    • 2
  • H. Robays
    • 1
  • H. De Wilde
    • 3
  • Y. Benoit
    • 2
  • B. De Moerloose
    • 2
  1. 1.Department of PharmacyGhent University HospitalGhentBelgium
  2. 2.Department of Pediatric Hemato-OncologyGhent University HospitalGhentBelgium
  3. 3.Department of Pediatric CardiologyGhent University HospitalGhentBelgium

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