Pharmacy World and Science

, Volume 27, Issue 2, pp 81–82 | Cite as

Treatment failures secondary to drug interactions with divalent cations and fluoroquinolone

  • K. W. GareyEmail author
  • Katie J. Suda
  • L. H. Danziger


We observed four cases of therapeutic failures while patients were simultaneously taking medications that contained divalent cations and oral fluoroquinolones. Patients improved after conversion to the intravenous formulation of the same antibiotics, proper spacing of the divalent cation, or conversion to a different antibiotic class. Patients prescribed oral fluoroquinolones should receive instructions on proper separations of these antibiotics with divalent cations. Health care professionals should be cognizant of these interactions and educated on their potential deleterious effect.


Antacids Ciprofloxacin Divalent cations Drug interactions Fluoroquinolones Levofloxacin 


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Copyright information

© Springer 2005

Authors and Affiliations

  1. 1.Department of Clinical Sciences and AdministrationUniversity of Houston College of PharmacyHoustonUSA
  2. 2.Metro Pharmacy AdministrationBaptist Memorial Health CareMermphisUSA
  3. 3.Department of Pharmacy Practice, College of PharmacyUniversity of Illinois at ChicagoChicagoUSA

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