Pharmacy World and Science

, Volume 27, Issue 2, pp 104–107 | Cite as

Utilisation of macrolides and the development of Streptococcus pyogenes resistance to erythromycin

  • Karel UrbánekEmail author
  • Milan Kolář
  • Luboslava Čekanová


Objectives: The aim of the study was to evaluate the relationship between the development of the resistance of Streptococcus pyogenes strains to erythromycin and the utilisation of macrolides in the Olomouc region, Czech Republic.

Method: During the period 1997–2001, data for utilisation of macrolides was obtained from the database of regional General Health Insurance Company and expressed in defined daily doses per 1000 patients per day. S. pyogenes strains were isolated from community patients suffering from acute bacterial tonsillitis. Their susceptibility to antibiotics was assessed by the disk diffusion method.

Result: Utilisation of macrolides increased by 13% in the period 1997–2001; their utilisation represented 11.40% of total antibiotic prescription in 1997 and 15.48% in 2001. Occurrence of erythromycin-resistant S. pyogenes strains increased significantly from 14% in 1997 to 32% in the year 2001 (P < 0.01). In 2000, macrolides consumption decreased non-significantly, but with no concomitant decrease in erythromycin-resistant S. pyogenes strains occurrence. Absolute susceptibility of S. pyogenes, the most important bacterial pathogen in community-acquired bacterial tonsillitis, to penicillin contrasts with increasing macrolide resistance.

Conclusions: The study documents the influence of increased utilisation of macrolides on bacterial resistance. Penicillin should be a first choice antibiotic in acute bacterial tonsillitis; macrolides should only be reserved for patients allergic to penicillins.


ATC-DDD system Antibiotics Czech Republic Drug resistance Drug use Macrolides Streptococcus pyogenes 


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Copyright information

© Springer 2005

Authors and Affiliations

  • Karel Urbánek
    • 1
    Email author
  • Milan Kolář
    • 3
  • Luboslava Čekanová
    • 2
  1. 1.Department of Pharmacology, Faculty of MedicinePalacký UniversityOlomoucCzech Republic
  2. 2.OlomoucCzech Republic
  3. 3.Department of Microbiology, Faculty of MedicinePalacký UniversityOlomoucCzech Republic

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